Benign Metastasizing Leiomyoma of the Lung with Spontaneous Pneumothorax

Abstract

A 47-year-old woman was admitted with recurrent pneumothorax. Preoperative chest computed tomography (CT) showed multiple lung nodules and cysts bilaterally. She had undergone enucleatic myomectomy 12 years earlier. Video-associated thoracoscopic biopsy was performed. Histopathologically, there were bulla-like dilated cystic changes, the walls of which showed spindle cell proliferation, causing pneumothorax. Hormone therapy was started after benign metastasizing leiomyoma resection; pneumothorax has not recurred in 7 months. Multiple residual lung nodules have decreased or disappeared on CT.

Concurrent benign metastasizing leiomyoma in the lung and lumbar spine with elevated standardized uptake value level in positron-emission tomography computed tomography

“…Some studies reported that PBML patients can also show some non-specific symptoms, such as cough, wheezing, chest pain, and recurrent pneumothorax. [ 19 ] If the lesions are located in the spine, patients may complain of pain and paresthesia due to the osteolytic damage and spinal canal compression by the tumor (Table 1 ), as seen in our patient. Notably, the main clinical symptoms of BML vary depending on the organs involved.…”

“…Thin-walled or thick-walled cystic or cavitary lesions have also been reported. [ 19 , 20 ] We also reviewed the imaging findings of spinal BML. The MRI examination of the spine generally shows masses in the vertebral bodies, which may lead to osteolytic damage and spinal canal compression.…”

Cancer Genes Mutations in Benign Metastasizing Leiomyoma: A Case Report

“…Prognosis depends on rate of progression and responsiveness to treatment. Time interval between hysterectomy and BML presentation is typically 15 years [1][2][3][4][5][6][7]. In an evaluation of 57 patients reported in the literature, survival from time of BML diagnosis is by average 11.6 years [14].…”

“…Most presentations involve the lungs, but may also involve lymph nodes, heart, brain, skin, and eye [2][3][4]. For the majority of the time, patients presented without symptoms and have incidental findings of small pulmonary nodules on chest X-ray or computed tomography scan (CT scan), but also sometimes presented with coughs, shortness of breath, hemoptysis, pleural effusions, or pneumothorax [5][6][7]. The pathogenesis of BML has not been clearly defined.…”