Benign necrotizing osteitis of the external auditory meatus

Kumar, B. Nirmal; Walsh, R. M.; Sinha, Arun K.; Courteney-Harris, R. G.; Carlin, W. V.

doi:10.1017/s0022215100137041

Cited by 6 publications

(6 citation statements)

References 5 publications

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“…In cases of prolonged intravenous therapy, outpatient treatment using an implantable catheter can be considered. The end of treatment should be decided according to imaging, controlling for the infectious disease . MRI can be useful to stage the disease and to assess complications, but pathologic images may persist after the eradication of the infection disease .…”

Section: Discussionmentioning

confidence: 99%

“…The end of treatment should be decided according to imaging, controlling for the infectious disease. 12,14,15 MRI can be useful to stage the disease and to assess complications, but pathologic images may persist after the eradication of the infection disease. 2,[16][17][18] In that context, radioleucoscintigraphy at 6 weeks is a reasonable option toward the decision to stop treatment.…”

Section: Discussionmentioning

confidence: 99%

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Skull base osteomyelitis: Incidence of resistance, morbidity, and treatment strategy

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Skull base osteomyelitis: Incidence of resistance, morbidity, and treatment strategy

et al. 2014

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“…Self-inflicted minor trauma is also a possible etiological factor in the development of benign osteonecrosis of the external ear canal [20][21][22][23]. Consequently, similar pathophysiological processes with disturbed wound healing due to compromised vascularity, reduction in viability of keratinocytes or reduction in extracellular matrix protein production and local trauma may also be responsible for osteonecrosis of the external ear canal in bisphosphonate-treated patients.…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of this clinical entity is still unclear, but it should be distinguished from radioosteonecrosis, malignant external otitis, or carcinoma of the external ear. Self-inflicted minor trauma of the external ear canal is also a presumed etiological factor in at least some cases of focal osteonecrosis of the external ear canal [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Bisphosphonate-induced osteonecrosis of the external ear canal: a retrospective study

Froelich

Radeloff

Köhler

et al. 2011

Eur Arch Otorhinolaryngol

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In 2003, osteonecrosis of the jaw was described as an intraoral complication of bisphosphonate therapy. More recently, cases of avascular necrosis of the hip were reported in patients with long-lasting bisphosphonate therapy. Thus, it was the aim of the present study to analyze cases of benign osteonecrosis of the external ear canal and to retrospectively identify a possible relationship to long-lasting bisphosphonate therapy. 13 patients with osteonecrosis of the external ear canal operated on between 2005 and 2009 were included. Patient histories were reviewed for possible previous or current bisphosphonate therapy. Three patients with osteonecrosis of the external ear canal and long-term bisphosphonate therapy could be identified. They had been treated either for breast cancer or multiple myeloma. Certainly, the jaw is an area of increased risk for developing osteonecrosis with its high mechanical stress and intraoral bacterial flora. However, osteonecrosis of the hips and the external ear canal in patients receiving long-term bisphosphonate therapy necessitate further investigation of a possible systemic, bisphosphonate-related phenomenon.

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“…Sua etiologia é controversa e tem sido descrita como provocada por estenose, traumática ou congênita, onde a descamação da pele retida, pressionada ou infectada poderia expandir o meato, rompendo a membrana timpânica e invadindo a caixa do tímpano e mastóide. Pode se apresentar mais circunscrita e ser relatada como osteíte necrosante (otite externa necrosante benigna) 13,14 , sendo, neste caso, sua etiologia relacionada com a anatomia vascular peculiar do osso timpânico que, insatisfatória, poderia levar à necrose circunscrita da pele e do osso do meato. Ou ainda pode ser confundida com outras doenças como a queratose obliterante (Keratosis obturans) 15 .…”

Section: Quanto àS Características Histológicas E Imunohistoquímicas unclassified

Estudo comparativo de aspectos histológicos e imunohistoquímicos entre o colesteatoma espontâneo do meato acústico externo e o colesteatoma adquirido da orelha média

Ribeiro¹,

Pereira²,

Almeida³

2004

Rev. Bras. Otorrinolaringol.

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Comparative study of the histological and immunohisochemical aspects of the spontaneous cholesteatomas of the external ear canal and the acquired cholesteatoma of the middle ear Resumo / SummaryObj etivo: Neste trabalho foram avaliadas as características histológicas e imunohistoquímicas (Ki-67 e CK-16) do colesteatoma espontâneo do meato acústico externo comparando-as com as do colesteatoma adquirido da orelha média. Forma de estudo: Caso controle. Material e Método: Fragmentos de colesteatoma do meato acústico externo foram submetidos a estudo histológico e imunohistoquímico com o intuito de verificar a expressão da CK16 e do antígeno nuclear Ki-67 nas células de sua matriz, e os resultados foram comparados com os encontrados no colesteatoma adquirido da orelha média. Resultados: Os aspectos histológico e imunohistoquímico quanto à presença da CK16 e do antígeno nuclear Ki-67 na matriz do colesteatoma do meato acústico externo foram idênticos àqueles encontrados no colesteatoma adquirido da orelha média. Discussão: Acreditamos que a ocorrência do colesteatoma do meato acústico externo seja devido ao comportamento anormal de células com potencial hiperproliferativo no epitélio do meato. Este potencial estaria relacionado com a presença da CK16 em uma região onde estes marcadores não são usualmente encontrados. Esta característica hiperproliferativa do colesteatoma do meato fica patente pela presença do antígeno nuclear Ki-67 nas células suprabasais de sua epiderme. Possivelmente esta doença deve ser desencadeada pela interação desta citoqueratina (CK16) com citocinas presentes no tecido conjuntivo subepitelial inflamado, como a TGF-∝. Conclusão: As características histológicas (presença de cones epiteliais) e histoquímicas (expressão da CK16 e do antígeno nuclear KI-67) são idênticas no colesteatoma adquirido da orelha média e no colesteatoma espontâneo do meato acústico externo. Histological and immunohistochemical aspects studied were identical in both types of cholesteatomas studied. Discussion: This study suggests that cholesteatomas of the external ear canal are caused by na abnormal behavior of the cells of the epithelium of the external canal with hyperproliferative properties. This potential could be explained by the presence of CK-16 at a location where these markers are not usually found. The hyperproliferative characteristic of the external ear canal cholesteatoma is possible due to the presence of the K-67 nuclear antigen in the epidermal suprabasal cells. It is possible that the disease is caused by an interaction between CK-16 and the cytocines (TGF-alpha),which are present in the subepithelial connective tissue undergoing na inflammatory process. Conclusions: The histological (presence of epithelial cones) and immunohistochemical (expression of CK 16 and the nuclear antigen KI-67) characteristics of both the external ear canal and the acquired middle ear cholesteatomas are identical. Fernando dePalavras-chave: colesteatoma, meato acústico externo, orelha média, CK16, KI-67.

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Benign necrotizing osteitis of the external auditory meatus

Cited by 6 publications

References 5 publications

Skull base osteomyelitis: Incidence of resistance, morbidity, and treatment strategy

Skull base osteomyelitis: Incidence of resistance, morbidity, and treatment strategy

Bisphosphonate-induced osteonecrosis of the external ear canal: a retrospective study

Estudo comparativo de aspectos histológicos e imunohistoquímicos entre o colesteatoma espontâneo do meato acústico externo e o colesteatoma adquirido da orelha média

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