Skull base osteomyelitis: Incidence of resistance, morbidity, and treatment strategy

Abstract

In our series, the prevalence of ciprofloxacin-resistant Pseudomonas strains increased over time. Along with fungal infections, they formed a group with a higher morbidity than that of ciprofloxacin-sensitive Pseudomonas infections that furthermore did not respond to oral outpatient treatment. This is why pathogen identification using biopsies is sometimes required to start a prolonged treatment.

A Case of Skull Base Osteomyelitis with Multiple Cerebral Infarction

“…Although gadolinium-enhanced MRI could not be applied on the present case due to renal failure, it would be more effective to evaluate the exact area of skull base osteomyelitis [7]. Since radiolabeled WBC scintigraphy reflects the extent of infection, particularly in cases of osteomyelitis, it is likely to be useful both for initial diagnosis and for assessment of treatment results for this disease [8]. …”

The antimicrobial peptide KR-12 promotes the osteogenic differentiation of human bone marrow stem cells by stimulating BMP/SMAD signaling

“…[21][22][23]34 With the increased emergence of drug-resistant bacteria in clinical bone infections, traditional antibiotics are becoming increasingly inefficient in their treatment, and AMPs, with lower drug resistance probability and good antibacterial properties, are being increasingly investigated. 24 AMPs are components of the innate immune system, and are considered potential alternatives to conventional antibiotics. 1,2 AMP LL-37 is an important rst line of defense against local infection and systemic pathogen invasion, and does not cause bacterial resistance.…”

“…16 Additionally, LL-37 fragments of different lengths have been tested for activity against bacteria, fungi, and cancer cells. [18][19][20][21][22][23][24][25][26][27][28][29] is the shortest peptide that demonstrates antibacterial activity. [17][18][19] This peptide retains the core amphipathic helix structure of LL-37 and contains 5 cationic residues.…”

Recurrent malignant otitis externa with multiple cranial nerve involvement: A case report

“…This resistance may be explained by prolonged antibiotic treatment and local use of ciprofloxacin ear drops. Le Clerc et al [10] reported that 25% of Pseudomonas aeruginosa strains isolated in NOE patients are resistant to ciprofloxacin. Also, an increasingly implicated organism in NOE is methicillin-resistant Staphylococcus aureus, which may be found in 15% of cases [11].…”