Benign neonatal hemangiomatosis

Stern, Jon K.; Wolf, John E.; Jarratt, Michael

doi:10.1016/s0190-9622(81)70044-6

Cited by 64 publications

(28 citation statements)

References 22 publications

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“…3,[25][26][27] Others have proposed the designation "multiple hemangiomas with or without extracutaneous involvement" as a more appropriate description of the spectrum of possible manifestations. 28 It has recently been recognized that "segmental" HOI have a markedly higher risk of being life-or functionthreatening and/or having associated structural anomalies, that they generally require more intensive and prolonged therapy, and that they are associated with a poorer outcome.…”

Section: Commentmentioning

confidence: 99%

Association of Solitary, Segmental Hemangiomas of the Skin With Visceral Hemangiomatosis

Metry

Hawrot²,

Altman³

et al. 2004

Arch Dermatol

120

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Section: Commentmentioning

confidence: 99%

Association of Solitary, Segmental Hemangiomas of the Skin With Visceral Hemangiomatosis

Metry

Hawrot²,

Altman³

et al. 2004

Arch Dermatol

120

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“…Since the conditions may appear identical at birth, it is therefore very important to differentiate this from the more common multiple cutaneous haemangiomatosis in which the internal organs are spared. In the latter entity, however, spontaneous involution occurs with no permanent sequelae [12]. Of note, two of the cases we report were considered initially to have been the benign cutaneous disease.…”

Section: Discussionmentioning

confidence: 75%

Diffuse infantile haemangiomatosis: clinicopathological features and management problems in five fatal cases

et al. 1991

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The clinicopathological features of five fatal cases of diffuse haemangiomatosis presenting in neonatal life or early infancy are presented. The infants all had multiple skin haemangiomas as well as deep-seated lesions in many different tissues that caused protean clinical manifestations and management problems. Because the outlook may be improved by early diagnosis and application of new modes of treatment, any infant with multiple cutaneous haemangiomas should be closely assessed for possible visceral involvement. Development of hepatomegaly, high-output cardiac failure, unexplained anaemia or thrombocytopenia in these infants should immediately suggest disseminated disease. Early recognition with implementation of steroid and/or antiangiogenic therapy, embolization and/or surgery is essential to improve the chances of survival.

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“…BNH was first reported by Stern et al . [8]. They increase rapidly in number and size (reaching up to 2cm in diameter) during the first few months and follow a benign course with spontaneous regression, usually within the first four months after their appearance.…”

Section: Discussionmentioning

confidence: 99%

Consumptive hypothyroidism in an Egyptian baby with benign neonatal hemangiomatosis: a case report

Metwalley

Farghaly

2013

J Med Case Reports

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IntroductionBenign neonatal hemangiomatosis is a condition in which multiple cutaneous hemangiomas appear at birth or shortly thereafter; visceral complications are absent. Here, we report a case of a consumption hypothyroidism in an Egyptian baby with benign neonatal hemangiomatosis.Case presentationAn 8-month-old Egyptian boy with benign neonatal hemangiomatosis was referred to our institution for evaluation of developmental delay. Initial examination revealed a quiet baby who was able to sit only with support. He had hypotonia, a large anterior fontanelle, puffy eyes, cold extremities, hypothermia, bradycardia, and abdominal distension. An examination of his skin revealed more than 100 dome-shaped red-purple cutaneous hemangiomas that varied in size from 5 to 10mm on the back, the abdomen and the extremities without mucus membrane involvement. He had low serum free thyroxine concentration and triiodothyronine levels and high thyroid-stimulating hormone and reverse-triiodothyronine levels. A work-up that involved appropriate imaging ruled out visceral involvement. Based on the above mentioned data, a diagnosis of consumptive hypothyroidism due to benign neonatal hemangiomatosis was made. He was started on oral thyroid medication which was gradually increased to 90μg L-thyroxine daily (15μg/kg/day). After three months of treatment, he was able to sit alone without support and he had normal levels of thyroid-stimulating hormone and serum free thyroxine.ConclusionThyroid function should be assessed periodically in babies with benign neonatal hemangiomatosis, especially if symptoms of hypothyroidism appear or the size and number of hemangiomatosis increase rapidly. Moreover, high doses of L-thyroxine may be needed to achieve euthyroidism during the infancy.

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Benign neonatal hemangiomatosis

Cited by 64 publications

References 22 publications

Association of Solitary, Segmental Hemangiomas of the Skin With Visceral Hemangiomatosis

Association of Solitary, Segmental Hemangiomas of the Skin With Visceral Hemangiomatosis

Diffuse infantile haemangiomatosis: clinicopathological features and management problems in five fatal cases

Consumptive hypothyroidism in an Egyptian baby with benign neonatal hemangiomatosis: a case report

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