Benign Thyroid Inclusions Within Cervical Lymph Nodes: An Alarming Incidental Finding

Ibrahim, N. B. N.; Milewski, P. J.; Gillett, Roy; Temple, J. G.

doi:10.1111/j.1445-2197.1981.tb05937.x

Cited by 17 publications

(12 citation statements)

References 3 publications

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“…Pathologic examination of the thyroid gland revealed one case of thyroid carcinoma in the contralateral lobe; however, the authors considered this to be incidental to the thyroid inclusion, because it was histologically dissimilar. Several other cases of ectopic thyroid tissue within lymph nodes, without evidence of primary thyroid carcinoma, have also been reported 9. Kozol et al10 reported on a series of 16 patients with ectopic thyroid tissue, which was incidentally discovered during the evaluation and treatment of primary hyperparathyroidism or benign thyroid disorder.…”

Section: Discussionmentioning

confidence: 99%

Unexpected findings in neck dissection for squamous cell carcinoma: Incidence and implications

et al. 2004

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Background. During the pathologic examination of neck dissections, unexpected pathologic findings may occasionally be encountered. These pathologic findings may simulate malignant disease and/or have implications on the already complicated management of patients with head and neck cancer.Methods. We retrospectively reviewed 202 consecutive patients with a preoperative diagnosis of squamous cell carcinoma (SCC), who underwent 307 neck dissections performed by a single surgeon and examined by a single pathologist.Results. Ten patients had an unexpected finding. These included metastatic papillary thyroid carcinoma, leukemia, lymphoma, Warthin's tumor, and tuberculosis. Two of three patients with benign-appearing thyroid tissue within lymph nodes received no further treatment, and both remained well beyond 6 years. Four patients succumbed to SCC; none died from the incidentally discovered pathologic findings.Conclusions. Unexpected pathologic findings may be present in more than 3% of neck dissections. Although this is usually indolent, with the underlying SCC remaining the main prognostic determinate, it may significantly complicate postoperative management.

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Section: Discussionmentioning

confidence: 99%

Unexpected findings in neck dissection for squamous cell carcinoma: Incidence and implications

et al. 2004

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“…The presence of malignant thyroid tissue within a lymph node should prompt an evaluation of the thyroid gland itself. Ibrahim et al 15 advocated that if a thyroid mass is not palpable on physical examination and a technetium thyroid scan is normal, these lateral aberrant lesions should be regarded as benign thyroid inclusions and do not represent metastatic lesions from a clinically undetectable thyroid carcinoma. However, in a review of 13 patients with lateral aberrant thyroid tissue, Crile 16 concluded that it was difficult to distinguish between metastatic disease and disease arising from lateral aberrant tissue.…”

Section: 1011mentioning

confidence: 98%

Significance and management of thyroid lesions in lymph nodes as an incidental finding during neck dissection

et al. 2001

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“…Normal-appearing thyroid tissue has rarely been encountered within the lymph nodes during histological examination, and has been regarded as having an embryologic explanation or being due to transport of thyroid tissue through the lymphatics (1)(2)(3)(4)(5). However, it is possible that minute and well-differentiated carcinoma of the thyroid metastasizes to the lymph nodes, as the microscopic appearance of metastatic papillary carcinoma may closely resemble non-neoplastic thyroid tissue (6).…”

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confidence: 99%

Intranodal benign thyroid tissue: Significance of HBME‐1 in differentiation from metastatic papillary thyroid carcinoma

Hirokawa¹,

Horiguchi²,

Wakatsuki³

et al. 2001

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The aim of this study was to determine the significance of HBME-1 immunostaining in the differentiation between intranodal benign thyroid tissue and metastatic papillary thyroid carcinoma in the lymph node. Immunohistochemically we examined normal-appearing intranodal thyroid tissue in four patients who did not show evidence of papillary carcinoma histologically or clinically. We also examined follicular-pattern-predominant papillary carcinoma with metastatic foci in the lymph nodes. Normal-appearing intranodal thyroid tissue and normal thyroid showed no immunopositivity for HBME-1. In contrast, all papillary carcinomas in both the lymph nodes and thyroid demonstrated strong positivity for HBME-1. HBME-1 was predominantly positive for the luminal surface of the tumor cells. The immunopositivity of the cuboidal and low columnar carcinoma cells was more intensive than that of the flat-shaped cells in the lymph nodes and thyroid. The results probably indicate that HBME-1 immunostaining is helpful in distinguishing between intranodal benign thyroid tissue and metastatic papillary carcinoma in lymph nodes. We emphasize that the HBME-1 reactivity should be evaluated in connection with the histological findings, and that positive and negative controls stained in parallel are necessary.

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Benign Thyroid Inclusions Within Cervical Lymph Nodes: An Alarming Incidental Finding

Cited by 17 publications

References 3 publications

Unexpected findings in neck dissection for squamous cell carcinoma: Incidence and implications

Unexpected findings in neck dissection for squamous cell carcinoma: Incidence and implications

Significance and management of thyroid lesions in lymph nodes as an incidental finding during neck dissection

Intranodal benign thyroid tissue: Significance of HBME‐1 in differentiation from metastatic papillary thyroid carcinoma

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