Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: Design and synthesis as anticancer agents

Synthesis of 1,3,4-oxadiazole derivatives from α-amino acid and acyl hydrazides under thermal heating or microwave irradiation conditions

“…[22][23][24][25] The dramatically shorter reaction time in the microwave-assisted conditions along with a very simple work-up, better yields as well as the absence of solvent when compared with conventional heating make the protocol more environmentally benign for the synthesis of 1,3,4-oxadiazoles.…”

“…18,19 Consequently, the synthesis of compounds containing this heterocyclic core has attracted considerable attention, and a wide variety of methods has been used for their assembly. The most common synthetic protocol toward the preparation of these compounds involves the dehydrative cyclization of diacylhydrazides using usually strong acidic reagents such as thionyl chloride, 20 phosphorus pentoxide, 21 phosphorus oxychloride, [22][23][24][25] and sulfuric acid. 26 In recent years 1,3,4-oxadiazoles have been inserted in route to design new peptidomimetics.…”

Antimicrobial and docking studies of (−)-catechin derivatives

“…Introduction of moderate-sized aliphatic chain at the C-3 hydroxyl position (lipophilic substituent) significantly improved the inhibitory effect of microbial growth (Park and Cho 2010). In view of this, we synthesized the derivatives of (-)-catechins and studied their activities of particular interest and, in continuation of our studies, on biologically active chemical entities (Husain et al 2012;Xie et al 2014;Kumar et al 2015). Herein we report the antimicrobial activities and docking studies of (-)-catechin analogs (1a-l) with an optimal alkyl chain length for their enhanced activities.…”

Design and Synthesis of Benzimidazole Analogs Endowed with Oxadiazole as Selective COX‐2 Inhibitor

“…This approach is gaining importance in therapeutic categories such as cytotoxicity and anti-inflammatory areas [21][22][23]. Recent trends in medicinal chemistry showed the popularity of molecular hybridization for drug design and development, which is based on combination of pharmacophoric moieties of different bioactive substances to make a new hybrid molecule with improved affinity and efficacy, as compared to parent drug [24][25][26]. Some reported biologically active agents, which contains benzimidazole residue and other related heterocyclic moieties, for example, celecoxib, mebendazole, indomethacin, and omeprazole and similarly designed hybrid molecules (5a-r) are structurally shown in Scheme 1.…”