Benzo(a) pyrene metabolism in vitamin A deficient rats

Kalamegham, R.; Krishnaswamy, Kamala

doi:10.1016/0024-3205(80)90016-8

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…The observed diminution in he patic cytochrome P-450 content, cytochrome b5 levels, and activity of benzo(a)pyrene hy droxylase is in accordance with the earlier reports [2,3,12], Also the decrease in hepatic UDP-GT activity (phase II enzyme) is in agreement with the earlier findings [20]. However, information on the role of vitamin A deficiency in altering the pulmonary phase I and phase II enzymes is lacking.…”

Section: Discussionsupporting

confidence: 82%

“…Renal metabolism of dimethylnitrosamine, however, was reported to be in tact. Similarly, diminished hepatic metabo lism of carcinogen in vitamin A deficiency indicated here and supported by other re ports [2,3,12] may result in delayed clear ance of the carcinogen, thereby its increased availability to other extrahepatic tissues par ticularly susceptible to these carcinogens such as lung.…”

Section: Body Weight Organ Weight and Hepatic Microsomal And Vitamimentioning

confidence: 99%

“…They were main tained for 5-6 weeks on vitamin A deficient caseinbased diet [12] composed of vitamin-free casein (20%), corn starch (39.8%), dextrose (30%), refined peanut oil (5%), saltmix (4%), choline chloride Vitamin A Deficiency, Pulmonary Drug-Metabolizing Enzymes Hepatic content of vitamin A was estimated by the method of Dugan et al [9].…”

Section: Methodsmentioning

confidence: 99%

“…Among a number of dietary factors, vitamin A defi ciency has been implicated as one of the con tributory factors towards enhanced suscepti bility of a number of organs to carcinogenesis [5,18]. Nearly all previously published work concerning drug metabolism in vitamin A deficiency has been done in the rat with the primary focus on the liver [2,3,12], How ever, very little information is available on the role of vitamin A in altering the micro somal drug metabolism in extrahepatic tis sues, such as lung. A study in this line is important because several PAHs like benzo(a)pyrene and other environmental pollu tants can exert their carcinogenic effect on lung as it is being exposed directly through inhalation to such compounds.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Vitamin A Deficiency on the Pulmonary and Hepatic Drug-Metabolizing Enzymes in Rat

Sc¹,

Khanduja²,

Mp³

et al. 1983

Enzyme

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The effect of vitamin A deficiency on the drug-metabolizing enzyme system of the lung and liver was analyzed in rats fed diets with or without vitamin A for 5-6 weeks. The hepatic level of vitamin A was significantly reduced in vitamin A deficient animals. The hepatic cytochrome P-450 and b(5) contents and activity of benzo(a)pyrene hydroxylase was significantly reduced in deficient animals. Contrary to this, pulmonary cytochrome P-450 and b(5) contents were above the control values. No alteration in pulmonary benzo(a)pyrene hydroxylase was noted. The uridine diphosphate-glucuronosyltransferase activity of digitonin- treated microsomal membranes was below the control values both in lung and liver. However, the native uridine diphosphate-glucuronosyltransferase activity remained unchanged in the liver and was below control values in the lung.

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Section: Discussionsupporting

confidence: 82%

Section: Body Weight Organ Weight and Hepatic Microsomal And Vitamimentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Vitamin A Deficiency on the Pulmonary and Hepatic Drug-Metabolizing Enzymes in Rat

Sc¹,

Khanduja²,

Mp³

et al. 1983

Enzyme

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“…PCM) and the experiment was carried out according to the protocol given in table I. Protein-deficient diet (PCM. 4% protein content) was prepared according to the composition outlined in table 2 [5].…”

Section: Diet and Drug Treatmentmentioning

confidence: 99%

Alterations and Reversibility of the Effects of Gossypol Acetic Acid on the Intestinal Uptake of End Product Nutrients in Normal and Protein Calorie-Malnourished Male Rats

Chadha¹,

Sanyal

Kanwar³

1991

Ann Nutr Metab

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The effects of gossypol acetic acid, an experimental male antifertility agent, 20 mg/kg body weight daily for 15 days and its subsequent withdrawal have been investigated on the intestinal uptake of certain end product nutrients, namely glucose, leucine, alanine and calcium, in normal and protein-calorie-malnourished (PCM) male albino rats. Gossypol feeding caused a reduction in body weight, intestinal weight and length, protein and nucleic acid contents in both normal and PCM animals. Serum parameters, e.g. total protein, albumin and globulin, also showed a decrease in PCM rats. PCM per se considerably elevated the uptake of nutrients but gossypol feeding inhibited the uptake of nutrients both in normal-fed and malnourished animals. Gossypol caused a decrease in the Na⁺-dependent (active) glucose uptake while the Na⁺-independent (passive) process was not altered. The kinetic parameters of glucose uptake indicate that gosyypol might be interfering with the transport/carrier protein of these nutrients as reduction in maximum uptake velocity (J_max) of these systems was observed without, however, any change in the affinity constant (K_t).

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Effect of vitamin A deficiency on the levels of glutathione and glutathione-S-transferase activity in rat lung and liver

1982

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Benzo(a) pyrene metabolism in vitamin A deficient rats

Cited by 7 publications

References 20 publications

Effect of Vitamin A Deficiency on the Pulmonary and Hepatic Drug-Metabolizing Enzymes in Rat

Effect of Vitamin A Deficiency on the Pulmonary and Hepatic Drug-Metabolizing Enzymes in Rat

Alterations and Reversibility of the Effects of Gossypol Acetic Acid on the Intestinal Uptake of End Product Nutrients in Normal and Protein Calorie-Malnourished Male Rats

Effect of vitamin A deficiency on the levels of glutathione and glutathione-S-transferase activity in rat lung and liver

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