2023
DOI: 10.1016/j.cbi.2023.110373
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Benzo[a]pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer

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Cited by 9 publications
(8 citation statements)
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“…Since our findings confirmed that mitochondrial ROS production and the mitochondrially mediated intrinsic apoptotic pathway are involved in B(a)P-induced toxicity, we went further to study the mitochondrial membrane potential (MMP) and activities of the respiratory enzyme complexes and their bioenergetics. Consistent with other studies [3,10,39,40,48,49], we also observed a three-to four-fold loss of membrane potential after B(a)P treatment, followed by the release of cytochrome c into the cytosol. AZD treatment abrogated the loss and brought the values close to control levels.…”
Section: Discussionsupporting
confidence: 93%
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“…Since our findings confirmed that mitochondrial ROS production and the mitochondrially mediated intrinsic apoptotic pathway are involved in B(a)P-induced toxicity, we went further to study the mitochondrial membrane potential (MMP) and activities of the respiratory enzyme complexes and their bioenergetics. Consistent with other studies [3,10,39,40,48,49], we also observed a three-to four-fold loss of membrane potential after B(a)P treatment, followed by the release of cytochrome c into the cytosol. AZD treatment abrogated the loss and brought the values close to control levels.…”
Section: Discussionsupporting
confidence: 93%
“…A reduction in mitochondrial ROS with AZD treatment was confirmed using a ROS-sensitive, mitochondrial-specific fluorogenic probe, CM-H2XRos (Mito Tracker ® Red), which specifically measures the intracellular production of hydrogen peroxide. Studies have shown the increased cellular content of MDA after treatment with B(a)P, indicating increased oxidative stress [6,39,[41][42][43]. Our study also confirmed increased MDA levels after B(a)P treatment, which were alleviated in the presence of AZD.…”
Section: Discussionsupporting
confidence: 86%
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