Benzodiazepines and Effectiveness of ECT

Johnstone, Eve C.; Deakin, J.F.W.; Frith, C. D.; Stevens, Marilyn; McPherson, Kerstin; Crow, Timothy J.

doi:10.1192/bjp.141.3.314

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…There has been some discussion as to whether the concurrent administration of benzodiazepines casts doubts on the results of comparisons of the effect of real and simulated ECT in the treatment of depressive illness (4)(5)(6).…”

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confidence: 99%

The relationship of concurrent benzodiazepine administration to seizure duration in ECT

Standish-Barry

Deacon

Snaith

1985

Acta Psychiatr Scand

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The relationship of concurrent benzodiazepine administration to seizure duration in ECT was examined. Administration of a standard oral dose of 10 mg diazepam to a series of patients suffering from major depressive disorder produced a significant reduction in men seizure length during ECT compared to length of ECT-induced seizure in those patients when they were benzodiazepine free. This finding is discussed.

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confidence: 99%

The relationship of concurrent benzodiazepine administration to seizure duration in ECT

Standish-Barry

Deacon

Snaith

1985

Acta Psychiatr Scand

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“…These statistically significant correlation coefficients were as follows: The Delayed Recall subtest of the Williams Memory Scale (Williams, 1968), .36, p < .001; the 1960s decade of the Famous Personalities Test (Johnstone, et al, 1980), .33, p < .001; the 1970s decade of the Famous Personalities Test, .285, p < .001; the Positional Learning Test (Weeks, Freeman, & Kendell, 1980), .32, p < .001; the Paired Associate Auditory Verbal Learning subtest of the Wechsler Memory Scale (Wechsler, 1945), .34, p < ,001; the Paired Associate Visual Design Learning subtest of the Meyer Cognitive Test Battery (Meyer, 1959), .40, p < .001; the Movement Time Index derived from choice reaction time tests (Byrne, 1976), .26, p < .001; and a test of incidental memory (Weeks et al, 1980), .35, p < .001. These statistically significant correlation coefficients were as follows: The Delayed Recall subtest of the Williams Memory Scale (Williams, 1968), .36, p < .001; the 1960s decade of the Famous Personalities Test (Johnstone, et al, 1980), .33, p < .001; the 1970s decade of the Famous Personalities Test, .285, p < .001; the Positional Learning Test (Weeks, Freeman, & Kendell, 1980), .32, p < .001; the Paired Associate Auditory Verbal Learning subtest of the Wechsler Memory Scale (Wechsler, 1945), .34, p < ,001; the Paired Associate Visual Design Learning subtest of the Meyer Cognitive Test Battery (Meyer, 1959), .40, p < .001; the Movement Time Index derived from choice reaction time tests (Byrne, 1976), .26, p < .001; and a test of incidental memory (Weeks et al, 1980), .35, p < .001.…”

Section: Studymentioning

confidence: 95%

The anomalous sentences repetition test: Replication and validation study

Weeks

1986

J. Clin. Psychol.

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Diazepam administration to mice prevents some of the changes in monoamine-mediated behaviour produced by repeated electroconvulsive shock treatment

1985

Psychopharmacology

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Administration to mice of electroconvulsive shock (ECS) five times over 10 days results in an enhanced 5-HTP-induced head twitch response, an enhanced apomorphine-induced locomotor response and an attenuated sedation response to the alpha 2-adrenoceptor agonist clonidine. Diazepam (1.25 mg/kg IP) injected 5 min before each ECS abolished the enhanced 5-HT- and dopamine-mediated responses but left the attenuated sedation response unaltered. When diazepam was given 5 min after each convulsion it still had the same effect, although its effects on the ECS-induced changes was blocked by administration of the specific benzodiazepine antagonist Ro 15-1788 (10 mg/kg IP) at the same time as diazepam. It is concluded that diazepam can abolish the ECS-induced changes in 5-HT- and DA-mediated behaviour, but not alpha 2-adrenoceptor-mediated responses, possibly by interfering with post-ictal changes. The implications for administration of benzodiazepines during electroconvulsive therapy (ECT) are discussed.

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Benzodiazepines and Effectiveness of ECT

Cited by 9 publications

References 14 publications

The relationship of concurrent benzodiazepine administration to seizure duration in ECT

The relationship of concurrent benzodiazepine administration to seizure duration in ECT

The anomalous sentences repetition test: Replication and validation study

Diazepam administration to mice prevents some of the changes in monoamine-mediated behaviour produced by repeated electroconvulsive shock treatment

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