Benzophenone and Benzoylphloroglucinol Derivatives from Hypericum sampsonii with Anti-Inflammatory Mechanism of Otogirinin A

Huang, Chun Yi; Chang, Tzu-Cheng; Wu, Yu; Chen, Yun; Chen, Jih Jung

doi:10.3390/molecules25194463

Cited by 18 publications

(12 citation statements)

References 41 publications

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“…Western blot analysis was performed according to the method previously reported [ 34 ]. In brief, A549 (1 × 10 5 cells) was seeded into 6 wells plate and grown until 85–90% confluent.…”

Section: Methodsmentioning

confidence: 99%

Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities

Chu¹,

Chang²,

Liao

et al. 2021

Marine Drugs

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Three new and rare chromone derivatives, epiremisporine C (1), epiremisporine D (2), and epiremisporine E (3), were isolated from marine-derived Penicillium citrinum, together with four known compounds, epiremisporine B (4), penicitrinone A (5), 8-hydroxy-1-methoxycarbonyl-6-methylxanthone (6), and isoconiochaetone C (7). Among the isolated compounds, compounds 2–5 significantly decreased fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 6.39 ± 0.40, 8.28 ± 0.29, 3.62 ± 0.61, and 2.67 ± 0.10 μM, respectively. Compounds 3 and 4 exhibited cytotoxic activities with IC50 values of 43.82 ± 6.33 and 32.29 ± 4.83 μM, respectively, against non-small lung cancer cell (A549), and Western blot assay confirmed that compounds 3 and 4 markedly induced apoptosis of A549 cells, through Bcl-2, Bax, and caspase 3 signaling cascades.

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“…Western blot analysis was performed according to the method previously reported [ 34 ]. In brief, A549 (1 × 10 5 cells) was seeded into 6 wells plate and grown until 85–90% confluent.…”

Section: Methodsmentioning

confidence: 99%

Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities

Chu¹,

Chang²,

Liao

et al. 2021

Marine Drugs

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“…Western blot analysis was performed according to the method previously reported [ 25 , 26 ]. Briefly, A549 and MCF-7 (1 × 10 5 cells) were seeded into 6-wells plate and grown until 85–90% confluent.…”

Section: Methodsmentioning

confidence: 99%

Dibenzofuran, 4-Chromanone, Acetophenone, and Dithiecine Derivatives: Cytotoxic Constituents from Eupatorium fortunei

Chang

Hsu

et al. 2021

IJMS

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Five new compounds, eupatodibenzofuran A (1), eupatodibenzofuran B (2), 6-acetyl-8-methoxy-2,2-dimethylchroman-4-one (3), eupatofortunone (4), and eupatodithiecine (5), have been isolated from the aerial part of Eupatorium fortunei, together with 11 known compounds (6‒16). Compounds 1 and 2 featured a new carbon skeleton with an unprecedented 1-(9-(4-methylphenyl)-6-methyldibe nzo[b,d]furan-2-yl)ethenone. Among the isolates, compound 1 exhibited potent inhibitory activity with IC50 values of 5.95 ± 0.89 and 5.55 ± 0.23 μM, respectively, against A549 and MCF-7 cells. The colony-formation assay demonstrated that compound 1 (5 μM) obviously decreased A549 and MCF-7 cell proliferation, and Western blot test confirmed that compound 1 markedly induced apoptosis of A549 and MCF-7 cells through mitochondrial- and caspase-3-dependent pathways.

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“…Moreover, in this study the brasilixanthone B has been isolated and identified in H. perforatum for the first time [ 295 ]. Strengthening the defensive role of xanthones, Huang and collaborators in H. sampsonii [ 178 , 296 ] showed that cDNAs encoding HsBPS and HsCHS were differentially regulated in the vegetative and in reproductive stages. In the vegetative stage, HsBPS was highly expressed in the roots; its transcript level was approximately 100 times higher than that of HsCHS, whereas the young leaves contained higher transcript levels of HsCHS.…”

Section: Organ and Tissue Localization Of Xanthones And Their Possibl...mentioning

confidence: 99%

Xanthones: Biosynthesis and Trafficking in Plants, Fungi and Lichens

Badiali

Petruccelli

Brasili

et al. 2023

Plants

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Xanthones are a class of secondary metabolites produced by plant organisms. They are characterized by a wide structural variety and numerous biological activities that make them valuable metabolites for use in the pharmaceutical field. This review shows the current knowledge of the xanthone biosynthetic pathway with a focus on the precursors and the enzymes involved, as well as on the cellular and organ localization of xanthones in plants. Xanthone biosynthesis in plants involves the shikimate and the acetate pathways which originate in plastids and endoplasmic reticulum, respectively. The pathway continues following three alternative routes, two phenylalanine-dependent and one phenylalanine-independent. All three routes lead to the biosynthesis of 2,3′,4,6-tetrahydroxybenzophenone, which is the central intermediate. Unlike plants, the xanthone core in fungi and lichens is wholly derived from polyketide. Although organs and tissues synthesizing and accumulating xanthones are known in plants, no information is yet available on their subcellular and cellular localization in fungi and lichens. This review highlights the studies published to date on xanthone biosynthesis and trafficking in plant organisms, from which it emerges that the mechanisms underlying their synthesis need to be further investigated in order to exploit them for application purposes.

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Benzophenone and Benzoylphloroglucinol Derivatives from Hypericum sampsonii with Anti-Inflammatory Mechanism of Otogirinin A

Cited by 18 publications

References 41 publications

Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities

Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities

Dibenzofuran, 4-Chromanone, Acetophenone, and Dithiecine Derivatives: Cytotoxic Constituents from Eupatorium fortunei

Xanthones: Biosynthesis and Trafficking in Plants, Fungi and Lichens

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