Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation

Abstract

Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate of glucose uptake in L6 myotubes and also augment glucose-stimulated insulin secretion in INS-1E β-cells and rat islets. We believe that such unique bi-functional compounds can be further used for the development of a new class of antidiabetic drugs.

Comparison of Transcriptome Profiles of the Fungus Botrytis cinerea and Insect Pest Bradysia odoriphaga in Response to Benzothiazole

“…Upregulation of PEPCK could promote glucose production, and upregulation of INSR and IRS could stimulate glucose uptake. The GO enrichment analysis also showed that carbohydrate transport, such as glucose transport, was significantly activated when B. odoriphaga was exposed to BT for 6 h. In summary, BT improved glucose uptake and transport in B. odoriphaga, consistent with a previous study of BT derivatives (Pasternak et al, 2014).…”

Feinstzerkleinerung organischer Partikeln in Rührwerkskugelmühlen: Bestimmung günstiger Formulierungen und Prozessparameter

“…The test was conducted using a proteasome activity assay kit according to the manufacturer′s instructions (Abcam, Cambridge, UK). Lysates of the INS‐1E cells were used as a source of the proteasome 39…”

A Chemical Chaperone‐Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

“…Lysates of the INS-1E cells were used as a source of the proteasome. [39] Measurement of mice neurological functions As disease progresses, SOD1 mice gradually begin to lose their ability to extend their legs. From day 90 the mice were evaluated weekly for their hind-limb reflex by a blinded observation.…”