Benzoxazinoids and iridoid glucosides from four Lamium species

Alipieva, Kalina; Taskova, Rilka M.; Evstatieva, Ljubka; Handjieva, Nedjalka; Попов, Симеон

doi:10.1016/j.phytochem.2003.08.001

Cited by 64 publications

(35 citation statements)

References 27 publications

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“…Among the isolated compounds in this study, harpagide or its acetyl derivative 8-O-acetylharpagide were also reported from other genera of Lamiaceae including Stachys (Calis et al 1992), Lamium (Alipieva et al 2003) and Galeopsis (Venditti et al 2013). Harpagide has also been reported from the genus Scrophularia (Tasdemir et al 2005).…”

Section: Discussionsupporting

confidence: 66%

Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites

Atay

Kırmızıbekmez

Kaiser

et al. 2016

Pharmaceutical Biology

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Context Some Ajuga L. (Lamiaceae) species are traditionally used for the treatment of malaria, as well as fever, which is a common symptom of many parasitic diseases. Objective In the continuation of our studies on the identification of antiprotozoal secondary metabolites of Turkish Lamiaceae species, we have investigated the aerial parts of Ajuga laxmannii. Materials and methods The aerial parts of A. laxmannii were extracted with MeOH. The H 2 O subextract was subjected to polyamide, C 18 -MPLC and SiO 2 CCs to yield eight metabolites. The structures of the isolates were elucidated by NMR spectroscopy and MS analyses. The extract, subextracts as well as the isolates were tested for their in vitro antiprotozoal activities against Plasmodium falciparum, Trypanasoma brucei rhodesiense, T. cruzi and Leishmania donovani at concentrations of 90-0.123 mg/mL. Results Two iridoid glycosides harpagide (1) and 8-O-acetylharpagide (2), three o-coumaric acid derivatives cis-melilotoside (3), trans-melilotoside (4) and dihydromelilotoside (5), two phenylethanoid glycosides verbascoside (6) and galactosylmartynoside (7) and a flavone-C-glycoside, isoorientin (8) were isolated. Many compounds showed moderate to good antiparasitic activity, with isoorientin (8) displaying the most significant antimalarial potential (an IC 50 value of 9.7 mg/mL). Discussion and conclusion This is the first report on the antiprotozoal evaluation of A. laxmannii extracts and isolates. Furthermore, isoorientin and dihydromelilotoside are being reported for the first time from the genus Ajuga.ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 66%

Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites

Atay

Kırmızıbekmez

Kaiser

et al. 2016

Pharmaceutical Biology

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“…Lamium album L. (white dead nettle) possesses astringent, antispasmodic, anti-inflammatory, antibiotic and bacteriostatic properties and is used in bladder, kidney and menstrual problems (5,6,7). It has been established that different extracts from L. album L. contain variety of compounds: iridoids, flavonoids, phenolic acids, triterpenes and mucialage.…”

Section: Introductionmentioning

confidence: 99%

Influence of Indole Butyric Acid on the Micropropagation ofLamium AlbumL.

Dimitrova

Yordanova

Dragolova

et al. 2010

Biotechnology & Biotechnological Equipment

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“…Benzoxazinone glucosides are secondary products of several Poaceae and of a few species belonging to dicotyledoneous families (Alipieva et al 2003;, Sicker et al 2000Sicker & Schulz 2002). They can be released into the environment by plant rotting or by root exudation.…”

Section: Introductionmentioning

confidence: 99%