Beobachtungen über Kerntheilungen in den Zellen der Geschwülste

Arnold, Julius

doi:10.1007/bf01878412

Cited by 45 publications

(9 citation statements)

References 2 publications

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“…However, this technological development was only able to deliver reliable and reproducible results by the late 1800s. Accordingly, anomalies of mitoses were described in 1879 by Julius Arnold [ 13 ], one year after Walther Flemming first introduced the terms “chromatin” and “mitosis” into the field [ 14 ]. Still, nine years passed before Wilhelm von Waldeyer-Hartz invented the term “chromosome” for the structures involved in mitosis [ 15 ].…”

Section: Human Chromosomesmentioning

confidence: 99%

From Human Cytogenetics to Human Chromosomics

Liehr

2019

IJMS

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Background: The concept of “chromosomics” was introduced by Prof. Uwe Claussen in 2005. Herein, the growing insights into human chromosome structure finally lead to a “chromosomic view” of the three-dimensional constitution and plasticity of genes in interphase nuclei are discussed. This review is dedicated to the memory of Prof. Uwe Claussen (30 April 1945–20 July 2008). Recent findings: Chromosomics is the study of chromosomes, their three-dimensional positioning in the interphase nucleus, the consequences from plasticity of chromosomal subregions and gene interactions, the influence of chromatin-modification-mediated events on cells, and even individuals, evolution, and disease. Progress achieved in recent years is summarized, including the detection of chromosome-chromosome-interactions which, if damaged, lead to malfunction and disease. However, chromosomics in the Human Genetics field is not progressing presently, as research interest has shifted from single cell to high throughput, genomic approaches. Conclusion: Chromosomics and its impact were predicted correctly in 2005 by Prof. Claussen. Although some progress was achieved, present reconsiderations of the role of the chromosome and the single cell in Human Genetic research are urgently necessary.

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Section: Human Chromosomesmentioning

confidence: 99%

From Human Cytogenetics to Human Chromosomics

Liehr

2019

IJMS

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“…10 In den letzten Jahren sind die Ursprünge der gegenwärti-gen Krebsforschung erneut intensiv diskutiert worden. 11 Dabei tauchte wiederholt die Frage auf, ob der deutsche Pathologe David von Hansemann (1858Hansemann ( -1920) -wie einige Autoren meinen -oder dessen Landsmann, der Biologe Theodor Boveri (1862-1915) -wie die meisten Autoren glauben -als Urheber der vielfach diskutierten, aber immer noch unbewiesenen und unscharf definierten, Chromosomentheorie des Krebses 12 zu gelten hätten.…”

Section: Eine Kontroverseunclassified

“Er korrigiert meine Anschauung und führt sie weiter fort.” Kommentare von David von Hansemann zu der Schrift von Theodor Boveri Zur Frage der Entstehung maligner Tumoren (1914)

Wunderlich

2011

Ber Wissenschaftsgesch

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According to many authors, the treatise on cancer written by Theodor Boveri in 1914 demonstrates astonishing foresight with respect to contemporary cancer research, in particular with respect to the genomic instability of tumors. In some recent publications, however, it has been claimed that not Boveri but primarily David von Hansemann deserves credit for these chromosomal theories of cancer origin. The claim seems to be unjustified because there are great differences, both in conception and in argumentation, between both opinions. In addition, it has been ignored that von Hansemann himself said that his views "were corrected and developed further by Boveri". In this paper two obviously unknown comments regarding Boveri's theory by von Hansemann are presented as examples. Furthermore, the paper points out that the pathologist von Hansemann was engaged in the formal genesis of tumors using descriptive methods. By contrast, the embryologist Boveri developed his hypotheses on the basis of the experimentally founded chromosome theory of inheritance in an attempt to explain the etiology or causal genesis of tumors. Thus, it can be concluded that Boveri developed the first genetic cancer theory in the history of medicine.

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“…It was also difficult to study human chromosomes from tissue sections. Crude estimates of the number of chromosomes in human cells at the end of the 19 th century gave counts of 16–38 with most in favour of 24 [ 35 - 37 ]. More realistic counts of 47 in testis and 48 in ovary, with a single X sex chromosome in males and two Xs in females, were reported by de Winiwarter in 1912 [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

History and evolution of cytogenetics

Ferguson‐Smith

2015

Mol Cytogenet

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The events that have led to the development of cytogenetics as a specialty within the life sciences are described, with special attention to the early history of human cytogenetics. Improvements in the resolution of chromosome analysis has followed closely the introduction of innovative technology. The review provides a brief account of the structure of somatic and meiotic chromosomes, stressing the high conservation of structure in plants and animals, with emphasis on aspects that require further research. The future of molecular cytogenetics is likely to depend on a better knowledge of chromosome structure and function.

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Beobachtungen über Kerntheilungen in den Zellen der Geschwülste

Cited by 45 publications

References 2 publications

From Human Cytogenetics to Human Chromosomics

From Human Cytogenetics to Human Chromosomics

“Er korrigiert meine Anschauung und führt sie weiter fort.” Kommentare von David von Hansemann zu der Schrift von Theodor Boveri Zur Frage der Entstehung maligner Tumoren (1914)

History and evolution of cytogenetics

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