�ber die Herkunft der Plasmahistaminase im anaphylaktischen Schock des Meerschweinchens

Heparin and Histaminase Release by Anaphylatoxin in Guinea Pigs

“…At the same time, the inferior vena cava was clamped between the dia phragm and the right heart. Two minutes later, blood (4-5 ml) was taken from the hepatic venous sinus [for details, see Schmutzler, H ahn, Seseke and Bernauer, 1966], Anaphylatoxin tests. AT was prepared by adding dextran (10 t 9 Oma-1, Knoll AG, Ludwigshafen, mean molecular weight: 292,000) to fresh rat serum (5 mg/5 ml) and incubat ing the mixture 1 h at 37°G [Giertz and Hahn, 1961].…”

Histaminase Liberating and Anticoagulant Activity of Heparin Released in Anaphylactic Shock in the Guinea Pig

“…Its mediating role in the anaphylactic release of histaminase (cf. G iertz, H ahn and L ogan, 1961) is suggested by the following observations: (1) Hista minase liberation, produced either by antigen or by heparin, oc curs in both instances directly from the liver (Schmutzler, H ahn, Seseke and Bernauer, 1966). (2) In anaphylactic shock, the major part of heparin is released from the liver (H ahn, G iertz and K rull, 1967).…”

Mechanism of Histaminase Liberation in Guinea Pig Anaphylaxis

“…This histaminase originates from the liver [Bernauer et al, 1964; Giertz etal., 1964;Schmutzler et al, 1966]. As could further be shown, heparin is a very strong histaminase liberator in the guinea pig.…”