�ber die These von den peripheren endokrinen (parakrinen) Dr�sen

Feyrter, F

doi:10.1007/bf01236394

Cited by 25 publications

(18 citation statements)

References 23 publications

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“…5,15,110,111 Using the whole-cell patch clamp technique on cultured NEBs from fetal rabbits, Youngson et al 112 showed that NEB cells exhibit features of excitable cells since they express voltageactivated potassium, calcium and sodium currents. Upon exposure to hypoxia (pO 2 25-30 mmHg), there was a reversible reduction (20-30%) in outward potassium current while inward sodium and calcium currents were unaffected by hypoxia. In current clamp mode, the closure of potassium channels by hypoxia produced an increase in spontaneous firing frequency and slope of the depolarization potential in NEB cells.…”

Section: Innervation and Chemoreception Function Of Pnecsmentioning

confidence: 98%

“…Since the 1940s, it has been evident that PNECs occur as solitary cells or clusters, 2,4 which Fröhlich referred to as corpuscles (Kö rperchen). He also suggested that they were innervated and functioned as chemoreceptors.…”

Section: Innervation and Chemoreception Function Of Pnecsmentioning

confidence: 99%

“…Classic NEBs respond to hypoxia by the release of serotonin (5-HT), which may result in bronchoconstriction, vasomotor toning and/or growth-factorlike properties 125,126 as well as positive feedback activation through serotonin type 3 autoreceptors residing on PNECs. 127,128 Direct evidence on hypoxia-induced 5-HT release comes from a study that showed a dose-dependent response in a range of pO 2 95-18 mmHg obtained from NEBs in lung slices by carbon fiber amperometry, which is able to measure in real time the release of single molecules of 5-HT. 127 This was modulated by L-type calcium channels.…”

Section: Innervation and Chemoreception Function Of Pnecsmentioning

confidence: 99%

“…1 They first appeared in the scientific literature in the 1940s, when Feyrter and Frö hlich [2][3][4] discovered clear cells (helle Zelle) in the bronchial epithelium due to their lucid cytoplasm in hematoxylin-eosin-stained sections. The PNEC system (solitary PNECs and neuroepithelial bodies or NEBs) consists of a distinct population of airway epithelial cells displaying endocrine and paracrine secretory mechanisms and associated with nerve fibers.…”

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confidence: 99%

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Functional facets of the pulmonary neuroendocrine system

Linnoila

2006

Laboratory Investigation

178

143

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Pulmonary neuroendocrine cells (PNECs) have been around for 60 years in the scientific literature, although phylogenetically they are ancient. Their traditionally ascribed functions include chemoreception and regulation of lung maturation and growth. There is recent evidence that neuroendocrine (NE) differentiation in the lung is regulated by genes and pathways that are conserved in the development of the nervous system from Drosophila to humans (such as achaete-scute homolog-1), or implicated in the carcinogenesis of the nervous or NE system (such as the retinoblastoma tumor suppressor gene). In addition, complex neural networks are in place to regulate chemosensory and other functions. Even solitary PNECs appear to be innervated. For the first time ever, we have mouse models for lung NE carcinomas, including the most common and virulent small cell lung carcinoma. Moreover, PNECs may be important for inflammatory responses, and pivotal for lung stem cell niches. These discoveries signify an exciting new era for PNECs and are likely to have therapeutic and diagnostic applications.

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Section: Innervation and Chemoreception Function Of Pnecsmentioning

confidence: 98%

Section: Innervation and Chemoreception Function Of Pnecsmentioning

confidence: 99%

Section: Innervation and Chemoreception Function Of Pnecsmentioning

confidence: 99%

mentioning

confidence: 99%

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Functional facets of the pulmonary neuroendocrine system

Linnoila

2006

Laboratory Investigation

178

143

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“…Since Feyrter (1938) described the 'diffuse endocrinic epithelial organ' as composed of 'clear cells' present in some endodermally derived organs, such cells have been identified also in the epithelium of the airways of several mammals including man (Frohlich, 1949;Feyrter, 1953;Bensch et al, 1965;Lauweryns and Peuskens, 1969;Cutz and Conen, 1972;Hage, 1972;Moosavi et al, 1973;Cutz et al, 1974;Lauweryns et al, 1974). These cells have been incorporated into the amineprecursor-uptake-decarboxylase (APUD) system proposed by Pearse (1969), and they are seen either as isolated cells or in groups.…”

mentioning

confidence: 99%

Quantitative characteristics of the Feyrter (APUD) cells of the neonatal rabbit lung in normoxia and chronic hypoxia.

Hernández-Vásquez¹,

Will²,

Quay³

1977

Thorax

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Developmental biology of gastrin and somatostatin cells in the antropyloric mucosa of the stomach

Larsson

2000

Microsc. Res. Tech.

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Gastrin is a hormone regulating gastric acid secretion and the growth of the gastrointestinal epithelium. It is expressed by endocrine tumors and by adenocarcinomas of the gastroenteropancreatic region and may represent an autocrine tumor growth factor. Gastrin is also implicated in the genesis of peptic ulcer disease both in conjunction with H. pylori infections and with gastrin‐producing tumors. The secretion and expression of gastrin are under the paracrine control of somatostatin, produced by D cells situated in close contact with gastrin‐producing G cells. D cells also contain neuronal nitric oxide synthase and appear to regulate apoptosis of G cells by paracrine release of nitric oxide. Both G and D cells are derived from a common multihormonal precursor cell present in the regenerative (isthmus) region of the gastric units. The precursor cells have been suggested to undergo asymmetrical divisions resulting in gastrin‐ and somatostatin‐producing daughter cells that remain in paracrine contact during their migration into the glands. The precursor cells also give rise to the third main antropyloric endocrine cell type; the serotonin‐producing EC cell. The maturation of all of these cell types is regulated by a number of transcription factors containing homeobox motifs (Pdx‐1, Pax 4 and 6, Isl‐1, Nkx6.1). Many of these also regulate the development of the central nervous system and the pancreas. The use of different combinations of these factors for regulating the expression of different hormones may explain the phenomenon of abberant hormone expression during development and carcinogenesis and the occurrence of multihormonal cells. Microsc. Res. Tech. 48:272–281, 2000 © 2000 Wiley‐Liss, Inc.

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�ber die These von den peripheren endokrinen (parakrinen) Dr�sen

Cited by 25 publications

References 23 publications

Functional facets of the pulmonary neuroendocrine system

Functional facets of the pulmonary neuroendocrine system

Quantitative characteristics of the Feyrter (APUD) cells of the neonatal rabbit lung in normoxia and chronic hypoxia.

Developmental biology of gastrin and somatostatin cells in the antropyloric mucosa of the stomach

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