Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF‐<i>κ</i>B Axis

Han, Chenglin; Wang, Zilong; Chen, Shuxiao; Li, Lin; Xu, Yingkun; Kang, Weiting; Wei, Chunhong; Ma, Hongbing; Wang, Muwen; Jin, Xunbo

doi:10.1155/2021/8851763

Cited by 25 publications

(14 citation statements)

References 65 publications

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“…As shown in Figure E, compared with BMDMs treated with PBS, the expression of NIK in BMDMs decreased significantly in correlation with the increased concentration of BCL treatment for 24 h. In the same way, the ratio of phosphorylated p65 (pi-p65)/p65 and phosphorylated IκB (pi-IκB)/IκB also declined statistically (Figure F). Increased BCL concentrations induce degradation of NIK, and hence, BCL treatment suppressed the activation of the ROS/NF-κB signaling pathway in BMDMs and inhibited the production of proinflammation cytokines, such as TNF-α and IL-1β, in agreement with prior research …”

Section: Resultssupporting

confidence: 90%

Dual-Targeted Nanoplatform Regulating the Bone Immune Microenvironment Enhances Fracture Healing

Zhou

Lin

Xiong

et al. 2021

ACS Appl. Mater. Interfaces

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The immune system and skeletal system are closely linked. Macrophages are one of the most important immune cells for bone remodeling, playing a prohealing role mainly through M2 phenotype polarization. Baicalein (5,6,7-trihydroxyflavone, BCL) has been well documented to have a noticeable promotion effect on M2 macrophage polarization. However, due to the limitations in targeted delivery to macrophages and the toxic effect on other organs, BCL has rarely been used in the treatment of bone fractures. In this study, we developed mesoporous silica and Fe3O4 composite-targeted nanoparticles loaded with BCL (BCL@MMSNPs-SS-CD-NW), which could be magnetically delivered to the fracture site. This induced macrophage recruitment in a targeted manner, polarizing them toward the M2 phenotype, which was demonstrated to induce mesenchymal stem cells (MSCs) toward osteoblastic differentiation. The mesoporous silicon nanoparticles (MSNs) were prepared with surface sulfhydrylation and amination modification, and the mesoporous channels were blocked with β-cyclodextrin. The outer layer of the mesoporous silicon was added with an amantane-modified NW-targeting peptide to obtain the targeted nanosystem. After entering macrophages, BCL could be released from nanoparticles since the disulfide linker could be cleaved by intracellular glutathione (GSH), resulting in the removal of cyclodextrin (CD) gatekeeper, which is a key element in the pro-bone-remodeling functions such as anti-inflammation and induction of M2 macrophage polarization to facilitate osteogenic differentiation. This nanosystem passively accumulated in the fracture site, promoting osteogenic differentiation activities, highlighting a potent therapeutic benefit with high biosafety.

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Section: Resultssupporting

confidence: 90%

Dual-Targeted Nanoplatform Regulating the Bone Immune Microenvironment Enhances Fracture Healing

Zhou

Lin

Xiong

et al. 2021

ACS Appl. Mater. Interfaces

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“…In the same way, the ratio of phosphorylated p65 (pi-p65)/p65 and phosphorylated IκB (pi-IκB)/IκB also declined statistically (Figure 2F). Increased BCL concentrations induce degradation of NIK, hence, BCL treatment suppressed the activation of the ROS/NF-κB signaling pathway in BMDMs and inhibited the production of proin ammation cytokines, such as TNF-α and IL-1β, in agreement with prior research [23].…”

Section: Bcl Induces M2 Macrophage Polarization Via Inhibition Of the Ros/nf-κb Signalingsupporting

confidence: 89%

Magnetically-Targeted Nanoparticle-Guided M2 Macrophage Polarization For Fracture Healing Promotion

Zhou

Lin

Xiong

et al. 2021

Preprint

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Background: Macrophages are essential for fracture healing, acting mainly through remodeling of the extracellular matrix and promotion of angiogenesis. The role of macrophages in regulating osteogenic differentiation, particularly that of the M2 phenotype, is increasingly researched. Baicalein (BCL) had also been shown to have pro-fracture-healing effects.Results: In this study, we developed mesoporous silica and Fe3O4 composite-targeted nanoparticles loaded with BCL (BCL@MMSNPs-SS-CD-NW), that could be magnetically delivered to the fracture site. These induced macrophage recruitment in a targeted manner, polarizing them towards the M2 phenotype, and thereby inducing MSCs towards osteoblastic differentiation. The mesoporous silicon nanoparticles (MSNs) were prepared with surface sulfhydrylation and amination modification, and the mesoporous channels were blocked with β-cyclodextrin. The outer layer of the mesoporous silicon was added with an amantane-modified NW targeting peptide to obtain the targeted nano-system. After entering macrophages, BCL could be released from nanoparticles since the disulfide linker could be cleaved by intracellular glutathione (GSH) resulting in the removing of CD gatekeeper, which is a key element in the pro-bone-remodeling functions, such as anti-inflammation and induction of M2 macrophage polarization to facilitate osteogenic differentiation.Conclusions: This nano-system passively accumulated in the fracture site, promoting osteogenic differentiation activities, highlighting a potent therapeutic benefit with high biosafety.

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“…Berbamine suppressed p-P65 and p-IκBα levels in bladder cancer cells. Berbamine induced significant shrinkage of the tumors in mice subcutaneously xenografted with T24 cancer cells [ 51 ].…”

Section: Berbamine Mediated Cancer Chemopreventive Effects In Tumor-b...mentioning

confidence: 99%

Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers

Farooqi

Wen

Attar

et al. 2022

IJMS

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Natural product research is a cornerstone of the architectural framework of clinical medicine. Berbamine is a natural, potent, pharmacologically active biomolecule isolated from Berberis amurensis. Berbamine has been shown to modulate different oncogenic cell-signaling pathways in different cancers. In this review, we comprehensively analyze how berbamine modulates deregulated pathways (JAK/STAT, CAMKII/c-Myc) in various cancers. We systematically analyze how berbamine induces activation of the TGF/SMAD pathway for the effective inhibition of cancer progression. We also summarize different nanotechnological strategies currently being used for proficient delivery of berbamine to the target sites. Berbamine has also been reported to demonstrate potent anti-cancer and anti-metastatic effects in tumor-bearing mice. The regulation of non-coding RNAs by berbamine is insufficiently studied, and future studies must converge on the identification of target non-coding RNAs. A better understanding of the regulatory role of berbamine in the modulation of non-coding RNAs and cell-signaling pathways will be advantageous in the effective translation of laboratory findings to clinically effective therapeutics.

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Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF‐κB Axis

Cited by 25 publications

References 65 publications

Dual-Targeted Nanoplatform Regulating the Bone Immune Microenvironment Enhances Fracture Healing

Dual-Targeted Nanoplatform Regulating the Bone Immune Microenvironment Enhances Fracture Healing

Magnetically-Targeted Nanoparticle-Guided M2 Macrophage Polarization For Fracture Healing Promotion

Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers

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