Berberine alleviates chlorpyrifos-induced nephrotoxicity in rats via modulation of Nrf2/HO-1 axis

Binmahfouz, Lenah S.; Hassanein, Emad H.M.; Bagher, Amina M.; Hareeri, Rawan H.; Alamri, Zaenah Z.; Algandaby, Mardi M.; Abdel-Daim, Mohamed M.; Abdel-Naim, Ashraf B.

doi:10.1016/j.heliyon.2024.e25233

Cited by 3 publications

(1 citation statement)

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“…Under normal circumstances, it can be controlled by the scavenger action of antioxidant enzymes like GSH, GSH-PX, SOD, and CAT. The imbalance between ROS and anti-oxidants results in the accumulation of harmful ROS leading to significant tissue damage and cellular apoptosis ( 49 , 50 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of moringa seed extract in chlorpyrifos-induced cerebral and ocular toxicity in mice

Alanazi,

Altyar,

Zaazouee

et al. 2024

Front. Vet. Sci.

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Chlorpyrifos (CPF) is one of the most commonly used organophosphosphate-based (OP) insecticides. Its wide use has led to higher morbidity and mortality, especially in developing countries. Moringa seed extracts (MSE) have shown neuroprotective activity, antioxidant, anti-inflammatory, and antibacterial features. The literature lacks data investigating the role of MSE against CPF-induced cerebral and ocular toxicity in mice. Therefore, we aim to investigate this concern. A total of 40 mature male Wistar Albino mice were randomly distributed to five groups. Initially, they underwent a one-week adaptation period, followed by a one-week treatment regimen. The groups included a control group that received saline, MSE 100 mg/kg, CPF 12 mg/kg, CPF-MSE 50 mg/kg, and CPF-MSE 100 mg/kg. After the treatment phase, analyses were conducted on serum, ocular, and cerebral tissues. MSE100 and CPF-MSE100 normalized the pro-inflammatory markers (interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α)) and AChE serum levels. CPF-MSE50 significantly enhanced these serum levels compared to CPF; however, it showed higher levels compared to the control. Moreover, the tissue analysis showed a significant decrease in oxidative stress (malondialdehyde (MDA) and nitric oxide (NO)) and an increase in antioxidant markers (glutathione (GSH), glutathione peroxidase (GSH-PX)), superoxide dismutase (SOD), and catalase (CAT) in the treated groups compared to CPF. Importantly, the significance of these effects was found to be dose-dependent, particularly evident in the CPF-MSE100 group. We conclude that MSE has a promising therapeutic effect in the cerebral and ocular tissues of CPF-intoxicated mice, providing a potential solution for OP public health issues.

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Section: Discussionmentioning

confidence: 99%