Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS

Biologically active isoquinoline alkaloids covering 2014–2018

“…357,358 In addition, berberine may be used to treat adenomyosis by inhibiting growth and inflammatory invasive phenotypes of ectopic stromal cells 359 and acute respiratory distress syndrome (ARDS) by alleviating endothelial glycocalyx degradation and promoting glycocalyx restoration in LPS-induced ARDS. 360…”

­­The Effects of Vagus Nerve Stimulation Mediated Protection of Intestinal Epithelial Glycocalyx on Acute Lung Injury Associated With Traumatic Hemorrhagic Shock/Resuscitation

“…However, the function of epithelial glycocalyx was still unclear, and some scholars proposed that mucosal epithelial glycocalyx could maintain physical barrier (28). In our study, we injected hyaluronidase, an enzyme for cleavage HA, into the ileum to nd out the effect of intestinal epithelial glycocalyx on intestinal permeability for the rst time, and used syndecan-1 as an indicator to detect the content of glycocalyx (12,29). Our results showed that intestinal barrier permeability increased after intestinal epithelial glycocalyx was damaged by hyaluronidase.…”

MCTR1 alleviates lipopolysaccharide‐induced acute lung injury by protecting lung endothelial glycocalyx

“…It has been reported that NF-κB is involved in the regulation of HPA expression and further degradation of the endothelial glycocalyx in various inflammation and cancer models. NF-κB signaling activation promotes HPA expression ， and the inhibition of NF-κB signaling pathway downregulating HPA expression have been found in LPS-induced ARDS (An et al, 2018;Hao et al, 2015;Huang et al, 2018;Zhang et al, 2010). Our results demonstrate that SIRT1 expression was downregulated and NF-κB p65 phosphorylation and HPA expression were upregulated in LPS-induced mice, which was reversed by MCTR1 treatment.…”