Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations

Tang, Jun; Feng, Yibin; Tsao, Sai‐Wah; Wang, Ning; Curtain, Robert P.; Wang, Youwei

doi:10.1016/j.jep.2009.08.009

Cited by 447 publications

(314 citation statements)

References 82 publications

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“…Recent studies have revealed that berberine suppresses the growth of some tumor cell lines (Letasiova et al, 2006;Jantova et al, 2007;Liang et al, 2008;Tang et al, 2009). Several studies have attempted to elucidate the mechanism of antitumor activity of berberine (Iizuka et al, 2000;Lin et al, 2004;Lee et al, 2006;Tan et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

Zhang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose-and time-dependent manner and was observed to induce a series of biochemical events, including the loss of mitochondrial membrane potential, release of cytochrome-c to cytosol, induction of proteins of the Bcl-2 family and caspases, and the cleavage of poly(ADP)-ribose polymerase. This suggested its ability to induce apoptosis. The results of a wound healing test revealed that berberine inhibited the migration of A431 cells. Ezrin was transfected into A431 cells by RNA interference. The level of expression of Ezrin in the transfected A431 cells was observed to decrease with berberine treatment, which suggested that berberine might inhibit the invasion of A431 cells through Ezrin. The results of this study 10553-10568 (2015) demonstrated that berberine could potentially inhibit proliferation, induce apoptosis, and inhibit the invasion of A431 cells.

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

Zhang

et al. 2015

Genet. Mol. Res.

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“…In recent years, extensive attention has been drawn to some major compounds of ZJW with regard to the anticancer effects (Tang et al 2009;Jantova et al 2007;Kang et al 2005;Pan et al 2012). Our previous studies (Wang et al 2008;Wang et al 2009) have shown that berberine and evodiamine have synergistic inhibitory effects on SMMGC-7721 cells, and ZJW is more powerful than C. Chinese Frach and E. rutaecarpa (Juss.)…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-proliferative effects of Zuojinwan on eight kinds of human cancer cell lines

et al. 2013

Cytotechnology

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Zuojinwan (ZJW), a famous Chinese medicinal formula, contains two medicinal herbs Coptis chinese Frach and Evodia rutaecarpa (Juss.) Benth in the ratio of 6: 1. The inhibitory effects of ZJW on eight kinds of human cancer cell lines including SMMC-7721, BEL-7402, BEL-7404, HepG2, A549, NCI-H446, NCI-H460 and HCT-116 cells were evaluated, and the possible mechanism was investigated. The growths of the eight kinds of cancer cells were inhibited by ZJW assessed through MTT assay. Flow cytometry assay revealed a sub-G1 peak with reduced DNA content was formed. The cell cycle was arrested in the G0/G1 phase in ZJW-treated SMMC-7721 and HepG2 cells, and in the S phase for NCI-H460 cells. Significant DNA damage was produced by ZJW assessed with single-cell gel electrophoresis assay. Morphological changes were also observed. Caspase-3 and -9 activities were increased following ZJW treatment. Western blot analysis showed that Bax and Bak protein levels were increased after ZJW treatment, while Bcl-2 and Bcl-xl protein levels were decreased. Our results suggest that ZJW has significant anti-cancer activities due to induction of mitochondria-dependent apoptosis pathway. Therefore, ZJW has the potential to be a novel chemotherapy drug to treat hepatoma, lung cancer and colon cancer by suppressing tumor growth.

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“…ber of reports, Coptis japonica Makino and its components, berberine, have been used to control airway allergic or infl ammatory diseases and reported to have anti-infl ammatory and anti-cancer effects (Yoo et al, 2008;Sun et al, 2009;Tang et al, 2009). On the other hand, it was previously reported that berberine stimulated basal mucin release from airway goblet cells, by our group .…”

Section: Introductionmentioning

confidence: 81%

Effect of Berberine on MUC5AC Mucin Gene Expression and Mucin Production from Human Airway Epithelial Cells

Sikder¹,

Lee²,

Lee³

et al. 2011

Biomolecules and Therapeutics

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We conducted this study to investigate whether berberine signifi cantly affects MUC5AC mucin gene expression and mucin production induced by epidermal growth factor (EGF), phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-α (TNF-α) from human airway epithelial cells. Confl uent NCI-H292 cells were pretreated with varying concentrations of berberine for 30 min and then stimulated with EGF, PMA or TNF-α for 24 h. MUC5AC mucin gene expression and mucin production were measured by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. Berberine was found to inhibit the expression of MUC5AC mucin gene induced by EGF, PMA or TNF-α. Berberine also inhibited the production of MUC5AC mucin protein stimulated by the same inducers. This result suggests that berberine can regulate the expression of mucin gene and production of mucin protein, by directly acting on human airway epithelial cells. Abstractber of reports, Coptis japonica Makino and its components, berberine, have been used to control airway allergic or infl ammatory diseases and reported to have anti-infl ammatory and anti-cancer effects (Yoo et al., 2008;Sun et al., 2009;Tang et al., 2009). On the other hand, it was previously reported that berberine stimulated basal mucin release from airway goblet cells, by our group . However, to the best of our knowledge, there are no reports about the effect of berberine on MUC5AC mucin gene expression and mucin production induced by epidermal growth factor (EGF), phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-α (TNF-α), from human airway epithelial cells. Therefore, in this study, we investigated whether berberine affects the expression of MUC5AC mucin gene and the production of mucin protein induced by EGF, PMA or TNF-α, from the NCI-H292 human pulmonary mucoepidermoid cell line.

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Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations

Cited by 447 publications

References 82 publications

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

In vitro anti-proliferative effects of Zuojinwan on eight kinds of human cancer cell lines

Effect of Berberine on MUC5AC Mucin Gene Expression and Mucin Production from Human Airway Epithelial Cells

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