Berberine as a natural compound inhibits the development of brown rot fungus Monilinia fructicola

Hou, D.; Yan, Chunqi; Liu, Hai-xi; Ge, Xizhen; Xu, Weijian; Tian, Pingfang

doi:10.1016/j.cropro.2010.05.015

Cited by 29 publications

(24 citation statements)

References 38 publications

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“…Berberine, a natural isoquinoline alkaloid that is found in many herbal plants, is used as an antimicrobial and a dye in Asia [21,22]. However, to avoid cytotoxicity at high doses, appropriate concentrations of berberine (much lower than the half maximal (50%) inhibitory concentration (IC 50 )) or concentrations not significantly different from the control should be used to assess its effects on the cytokine gene expression profile in mouse primary splenocytes in the 4 different in vitro experimental models that were used in this study.…”

Section: Resultsmentioning

confidence: 99%

Berberine down-regulates the Th1/Th2 cytokine gene expression ratio in mouse primary splenocytes in the absence or presence of lipopolysaccharide in a preventive manner

Lin

2011

International Immunopharmacology

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Section: Resultsmentioning

confidence: 99%

Berberine down-regulates the Th1/Th2 cytokine gene expression ratio in mouse primary splenocytes in the absence or presence of lipopolysaccharide in a preventive manner

Lin

2011

International Immunopharmacology

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“…Second, berberine retards the growth of some fungi [23]. For example, our previous study reported the strong inhibition of berberine against M. fructicola [8]. Furthermore, chitosan was reported to inhibit bacteria [24].…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study reported the notable inhibition of berberine against M. fructicola [8]. This finding aroused an interest in utilizing berberine to manage brown rot.…”

Section: Introductionmentioning

confidence: 99%

Disease control during peach preservation with a berberine-chitosan composite membrane

Yan¹,

Tian³

2012

Fruits

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Disease control during peach preservation with a berberine-chitosan composite membrane.Abstract -Introduction. Peach brown rot caused by the fungus Monilinia fructicola is a major disease leading to considerable economic loss during storage. Our previous study uncovered the striking inhibition of the natural alkaloid berberine against M. fructicola. Materials and methods. A berberine-chitosan composite membrane (BCCM) able to slowly release berberine was prepared and used for peach preservation. The examined fruits were stored at 4°C and treated as follows: (I) control fruits without packaging; (ii) fruits that were transiently immersed in pre-solidified BCCM liquid and taken out; (iii) fruit coating either with a BCCM, or with a membrane containing chitosan only (without berberine), and (iv) fruit coating with a PVC membrane. Results and discussion. The group immersed in BCCM showed a high infection rate due to the cytotoxicity of acetic acid, but the coating group showed only a 10% infection rate after 40 days of storage. Moreover, the BCCM-coating group showed a significantly lower infection rate than that coated with chitosan membrane (without berberine), clearly indicating the antimicrobial activity of berberine therein. Consequently, packed in BCCM and stored at 4°C, peach fruits could be well preserved over 40 days with very low infection. Conclusion. Considering its safety and low cost, the berberine-containing chitosan composite membrane could be applicable in controlling diseases during peach storage.China / Prunus persica / peaches / storage / disease control / Monilinia fructicola / postharvest technology / coating / membranes Protection sanitaire de la pêche en cours de stockage à l'aide d'une membrane composite de berbérine-chitosane.Résumé -Introduction. La pourriture brune de la pêche causée par le champignon Monilinia fructicola est une maladie grave entraînant une perte économique considérable pendant le stockage. L'une de nos études précédentes avait mis en évidence l'inhibition surprenante de la berbérine, alcaloïde naturel, contre M. fructicola. Matériel et méthodes. Une membrane composite de berbérine-chitosane (BCCM) capable de libérer lentement de la berbérine a été préparée et utilisée pour la protection de pêches. Les fruits étudiés ont été stockés à 4°C et ont subi les traitements suivant : (i) fruits témoins sans emballage; (ii) fruits transitoirement immergés dans une solution de BCCM pré-solidifiée, puis sortis; (iii) fruits revêtus soit avec une membrane BCCM, soit avec une membrane à base de chitosane seule (sans berbérine), et (iv) fruits revêtus avec un film de PVC. Résultats et discussion. Les fruits immergés dans une solution de BCCM ont montré un taux d'infection élevé du fait de la cytotoxicité de l'acide acétique présent dans le liquide, mais les fruits avec revêtement n'ont présenté que 10 % de fruits infectés après 40 jours de stockage. De plus, les fruits revêtus d'une membrane BCCM ont présenté un taux d'infection significativement plus faible que celui des fruits revêt...

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“…Botrytis cinerea, Alternaria solani and Monilinia fructicola [125]. Dehydrocorydalmine and oxyberberine, two berberine structurally-related alkaloids were found to be less active against Fusarium species with SPIC50 close to 1000 mg/L.…”

Section: Alkaloidsmentioning

confidence: 99%

Natural Products from Plants as Potential Source Agents for Controlling Fusarium

Prieto¹,

Patiño²,

Plazas³

et al. 2013

Fungicides - Showcases of Integrated Plant Disease Management From Around the World

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Berberine as a natural compound inhibits the development of brown rot fungus Monilinia fructicola

Cited by 29 publications

References 38 publications

Berberine down-regulates the Th1/Th2 cytokine gene expression ratio in mouse primary splenocytes in the absence or presence of lipopolysaccharide in a preventive manner

Berberine down-regulates the Th1/Th2 cytokine gene expression ratio in mouse primary splenocytes in the absence or presence of lipopolysaccharide in a preventive manner

Disease control during peach preservation with a berberine-chitosan composite membrane

Natural Products from Plants as Potential Source Agents for Controlling Fusarium

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