Berberine as a Potential Agent for the Treatment of Colorectal Cancer

Jiang, Xi; Jiang, Zhongxiu; Jiang, Min; Sun, Yan

doi:10.3389/fmed.2022.886996

Cited by 17 publications

(16 citation statements)

References 202 publications

(201 reference statements)

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“…Studies in the literature have also shown that berberine is used in humans. Jiang et al reported that berberine is a safe and effective drug in patients with colorectal cancer and is beneficial in the treatment of these patients 20 . Similarly, human studies have shown that berberine is an effective agent in neurodegenerative disorders such as the Parkinson’s and Alzheimer’s diseases due to its potent antioxidant effect 21 .…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of berberine on noise-induced hearing loss: a rat model

Kılıç

Sakat

Şahin

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Noise-induced hearing loss is a preventable form of hearing loss that has serious social and economic impacts. This study aimed to investigate the protective effect of berberine, a potent antioxidant and anti-inflammatory agent, against Noise-induced hearing loss. METHODS: After applying distortion product otoacoustic emission, 28 female Sprague-Dawley rats were randomly divided into four groups. Group 1 was designated as acoustic trauma group, and rats in this group were exposed to white noise for 12 h at an intensity of 4 kHz 110 dB sound pressure level. Group 2 was the control group. Group 3 was designated as the berberine group, and 100 mg/kg of berberine was administered to rats in this group by intragastric lavage for five consecutive days. Group 4 was designated as the acoustic trauma+berberine group. distortion product otoacoustic emission was repeated on the 6 th day of the study and cochlear tissues of rats were dissected for histopathological and immunohistochemical analyses after sacrificing rats. RESULTS: The distortion product otoacoustic emission results showed a significant decrease in signal-noise ratio values at higher frequencies in rats of the trauma group compared to those in other groups. Acoustic trauma caused severe histopathological impairment at cochlear structures together with severe 8-hydroxy-2-deoxyguanosine expression. Rats in the acoustic trauma+berberine group showed mild histopathological changes with mild 8-hydroxy-2-deoxyguanosine expression and better signal-noise ratio values. CONCLUSION: The histopathological and audiological findings of this experimental study showed that berberine provides protection in Noiseinduced hearing loss and may have the potential for use in acoustic trauma-related hearing losses.

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Section: Discussionmentioning

confidence: 99%

The effectiveness of berberine on noise-induced hearing loss: a rat model

Kılıç

Sakat

Şahin

et al. 2022

Rev. Assoc. Med. Bras.

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“…Coptis chinensis and Coptis teeta have been medicinally used in Eastern Asian regions for treating symptoms related to “damp-heat” of the body, such as fever, swelling, or dyspepsia. Berberine, a monomeric alkaloid compound included in Coptis, has been studied in previous studies and proven to exert anti-cancer effects by multiple mechanisms [ 141 , 142 , 143 , 144 , 145 ]. A recent study showed that berberine could alleviate CIPN symptoms induced by cisplatin treatment [ 74 ] as well.…”

Section: Candidates For New Therapeutics: Approach With Knowledge Fro...mentioning

confidence: 99%

Therapeutics for Chemotherapy-Induced Peripheral Neuropathy: Approaches with Natural Compounds from Traditional Eastern Medicine

Chung

Kim

2022

Pharmaceutics

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Chemotherapy-induced peripheral neuropathy (CIPN) often develops in patients with cancer treated with commonly used anti-cancer drugs. The symptoms of CIPN can occur acutely during chemotherapy or emerge after cessation, and often accompany long-lasting intractable pain. This adverse side effect not only affects the quality of life but also limits the use of chemotherapy, leading to a reduction in the survival rate of patients with cancer. Currently, effective treatments for CIPN are limited, and various interventions are being applied by clinicians and patients because of the unmet clinical need. Potential approaches to ameliorate CIPN include traditional Eastern medicine-based methods. Medicinal substances from traditional Eastern medicine have well-established analgesic effects and are generally safe. Furthermore, many substances can also improve other comorbid symptoms in patients. This article aims to provide information regarding traditional Eastern medicine-based plant extracts and natural compounds for CIPN. In this regard, we briefly summarized the development, mechanisms, and changes in the nervous system related to CIPN, and reviewed the substances of traditional Eastern medicine that have been exploited to treat CIPN in preclinical and clinical settings.

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“…The colorectal cancer is the third most common cancer in the world, accounting for more than a third of all cancer cases worldwide, and the mortality rate is usually high (1,2).…”

Section: Introductionmentioning

confidence: 99%

Surgical treatment of locally advanced right colon cancer invading neighboring organs

Kang²,

Zhang³

et al. 2023

Front. Med.

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PurposeInvasion of the pancreas and/or duodenum with/without neighboring organs by locally advanced right colon cancer (LARCC) is a very rare clinical phenomenon that is difficult to manage. The purpose of this review is to suggest the most reasonable surgical approach for primary right colon cancer invading neighboring organs such as the pancreas and/or duodenum.MethodsAn extensive systematic research was conducted in PubMed, Medline, Embase, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) using the MeSH terms and keywords. Data were extracted from the patients who underwent en bloc resection and local resection with right hemicolectomy (RHC), the analysis was performed with the survival rate as the outcome parameters.ResultsAs a result of the analysis of 117 patient data with locally advanced colon cancer (LACC) (73 for males, 39 for females) aged 25–85 years old from 11 articles between 2008 and 2021, the survival rate of en bloc resection was 72% with invasion of the duodenum, 71.43% with invasion of the pancreas, 55.56% with simultaneous invasion of the duodenum and pancreas, and 57.9% with invasion of neighboring organs with/without invasion of duodenum and/or pancreas. These survival results were higher than with local resection of the affected organ plus RHC.ConclusionWhen the LARCC has invaded neighboring organs, particularly when duodenum or pancreas are invaded simultaneously or individually, en bloc resection is a reasonable option to increase patient survival after surgery.

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Berberine as a Potential Agent for the Treatment of Colorectal Cancer

Cited by 17 publications

References 202 publications

The effectiveness of berberine on noise-induced hearing loss: a rat model

The effectiveness of berberine on noise-induced hearing loss: a rat model

Therapeutics for Chemotherapy-Induced Peripheral Neuropathy: Approaches with Natural Compounds from Traditional Eastern Medicine

Surgical treatment of locally advanced right colon cancer invading neighboring organs

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