Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils

Wang, Yuan; Wang, Faqiang; Yang, Duomeng; Tang, Xiangxu; Li, Hongmei; Lv, Xiuxiu; Lu, Daxiang; Wang, Huadong

doi:10.1016/j.intimp.2016.03.041

Cited by 21 publications

(13 citation statements)

References 29 publications

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“…After that, severe acute kidney injury [24,25], lung injury [26], liver failure [27] as well as cognitive impairments were all detrimental to sepsis patients. Early research reported that BBR combination with yohimbine was helpful in the early phase of sepsis in which drugs were administered 2 h after CLP surgery [15]. Combined with our research, BBR administration alone before CLP surgery also showed beneficial effects towards sepsis in animals.…”

Section: Researchsupporting

confidence: 77%

“…During the research of sepsis, BBR could prevent intestinal mucosal barrier damage at the early phase of disease [14]. In 2016, Yuan Wang revealed that neutrophil tissue infiltration and multiorgan dysfunction induced by sepsis was partly attenuated by combination treatment with BBR and yohimbine [15]. Research on whether BBR treatment alone improves cognitive functions after sepsis is sparse and not well documented.…”

Section: Survival Ratementioning

confidence: 99%

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Berberine Prevents Cognitive Disorders Induced by Sepsis by Regulating the Inflammatory Cytokines, Oxidative Stress and Neuronal Apoptosis in Rat Brain

Shi¹,

Zhao²,

Ge³

et al. 2018

Neuropsychiatry

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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and can cause a huge burden to whole families and to society in terms of medical costs. Cognitive disorders induced by sepsis are still exasperating problems in clinical research. This paper examines a new measure of berberine (BBR) in sepsis induced cognitive disorders based on CLP surgery. BBR is one of many extracts from Chinese traditional herbs and exhibits antidiabetic, anticancer and antioxidant activities in treating various clinical disorders. Whether BBR shows efficacy in improving survival rates and inhibiting the extent of cognitive disorders after sepsis was explored in this paper. The result revealed that BBR treatment significantly improved the survival rate and cognitive disorders in septic rats. Increased levels of antioxidant superoxide dismutase (SOD) and reduced levels of lipid peroxidation malondialdehyde (MDA) were exhibited in the serum and brain tissue of the BBR treatment group. Moreover, the inflammatory cytokine (IL-1β, IL-4, IL-6, TNF-α) levels in the brain tissue were all decreased in the BBR treatment group compared to those in the sepsis group. BBR also largely protected the cells from apoptosis in the cerebral cortex and hippocampal CA1 region. Overall, our results indicated that BBR exhibited protective effects on survival rate and cognitive disorders after sepsis by inhibiting the release of inflammatory cytokines, oxidative stress and neuronal apoptosis in brain tissue. Therefore, BBR is a potential drug that shows efficacy in avoiding death rates and cognitive disorder after sepsis.

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Section: Researchsupporting

confidence: 77%

Section: Survival Ratementioning

confidence: 99%

Berberine Prevents Cognitive Disorders Induced by Sepsis by Regulating the Inflammatory Cytokines, Oxidative Stress and Neuronal Apoptosis in Rat Brain

Shi¹,

Zhao²,

Ge³

et al. 2018

Neuropsychiatry

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“…Furthermore, in the current results, we found that berberine can regulate serum IL‐1β and TNF‐α in LPS‐challenged broilers. The main reason may be that berberine can regulate the function of macrophages and neutrophils, thus controlling the secretion of IL‐1β and TNF‐α (Wang et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Even under normal conditions, animals are inevitably exposed to stress from bacteria or their products, such as LPS, in the environment, which can affect the health status and inhibit growth performance in animals (Wang et al, ; Zhao et al, ). Broilers grow rapidly due to genetic selection, but they are also more susceptible to LPS exposure than other livestock.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, berberine has received extensive attention in the field of prevention and treatment of inflammatory diseases due to its anti‐inflammatory and antioxidative characteristics. Although many studies have demonstrated that berberine plays an important role in regulating the immune and antioxidant system in human (Wang et al, ; Yang et al, ), few studies have been conducted on the anti‐inflammatory and antioxidant effects of berberine supplementation in animals, especially chickens.…”

Section: Introductionmentioning

confidence: 99%

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Effects of berberine on the growth performance, antioxidative capacity and immune response to lipopolysaccharide challenge in broilers

Yang

Liu

Liang

et al. 2019

Animal Science Journal

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This study evaluated the effects of berberine on growth performance, immunity, haematological parameters, antioxidant capacity, and the expression of immune response‐related genes in lipopolysaccharide (LPS)‐challenged broilers. We assigned 120 one‐day‐old male broilers (Ross 308) to two treatment groups; each group included two subgroups, each of which included six replicates of five birds per replicate. The experiment used a 2 × 2 factorial arrangement with berberine treatment (0 or 60 mg/kg dietary) and challenge status [injection of saline (9 g/L w/v) or LPS (1.5 mg/kg body weight)] as the main factors. On days 14, 16, 18 and 20, broilers were intraperitoneally injected with LPS or physiological saline. Blood and liver samples were collected on day 21. Dietary berberine supplementation significantly alleviated the compromised average daily gain and average daily feed intake (p < 0.05) caused by LPS. The LPS challenge led to increased lymphocyte and white blood cell (WBC) counts, malondialdehyde (serum and liver) content, and immunoglobulin G and M, tumour necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β) expression (p < 0.05) and significantly reduced serum total superoxide dismutase (T‐SOD) activity (p < 0.05). Dietary berberine significantly mitigated the LPS‐induced decreases in the mRNA expression of nuclear factor‐kappa B (NF‐κB), TNF‐α, IL‐1β, inducible nitrite synthase and cyclooxygenase‐2 (p < 0.05) in the liver. In conclusion, berberine supplementation has a positive effect on LPS challenge, which may be related to the increase in antioxidant enzyme activity and inhibition of both NF‐κB signalling and the expression of inflammatory mediators.

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The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

et al. 2020

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Sepsis and septic shock are still a leading cause of mortality and morbidity in intensive care units worldwide. Sepsis is an uncontrolled and excessive response of the innate immune system toward the invading infectious microbes, characterized by the hyper‐production of pro‐inflammatory mediators such as interleukin (IL)‐1β, IL‐6, tumor‐necrosis factor (TNF)‐α, and high‐mobility group box 1 (HMGB1). In severe sepsis, the overwhelming production of pro‐inflammatory cytokines and reactive oxygen species may compromise organ function and lead to the induction of abnormal apoptosis in different organs, resulting in multiple organ dysfunction syndrome and death. Hence, compounds that are able to attenuate inflammatory responses may have therapeutic potential for sepsis treatment. Understanding the pathophysiology and underlying molecular mechanisms of sepsis may provide useful insights in the discovery and development of new effective therapeutics. Therefore, numerous studies have invested much effort into elucidating the mechanisms involved with the onset and development of sepsis. The present review mainly focuses on the molecules and signaling pathways involved in the pathogenicity of sepsis. Additionally, several well‐known natural bioactive herbal compounds and phytochemicals, which have shown protective and therapeutic effects with regard to sepsis, as well as their mechanisms of action, are presented. This review suggests that these phytochemicals are able to attenuate the overwhelming inflammatory responses developed during sepsis by modulating different signaling pathways. Moreover, the anti‐inflammatory and cytoprotective activities of phytochemicals make them potent compounds to be included as complementary therapeutic agents in the diets of patients suffering from sepsis in an effort to alleviate sepsis and its life‐threatening complications, such as multi‐organ failure.

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Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils

Cited by 21 publications

References 29 publications

Berberine Prevents Cognitive Disorders Induced by Sepsis by Regulating the Inflammatory Cytokines, Oxidative Stress and Neuronal Apoptosis in Rat Brain

Berberine Prevents Cognitive Disorders Induced by Sepsis by Regulating the Inflammatory Cytokines, Oxidative Stress and Neuronal Apoptosis in Rat Brain

Effects of berberine on the growth performance, antioxidative capacity and immune response to lipopolysaccharide challenge in broilers

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

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