Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance

Chen, Ying; Chen, Yuling; Liang, Yubin; Chen, Hongda; Ji, Xiaoling; Huang, Min

doi:10.1016/j.biopha.2019.109670

Cited by 98 publications

(73 citation statements)

References 52 publications

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“…Upon further investigation, berberine was reported to alleviate ischemic arrhythmias [ 33 ], mitigate cognitive decline in a triple-transgenic mouse model of Alzheimer’s disease [ 34 ], and ameliorate lipopolysaccharide-induced inflammatory response [ 35 ]. Palmatine has been proved as an anti-inflammatory drug for clinical treatment of gastrointestinal infections, surgical infections, and gynecological inflammation [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Simultaneous Qualitative and Quantitative Evaluation of the Coptidis Rhizoma and Euodiae Fructus Herbal Pair by Using UHPLC-ESI-QTOF-MS and UHPLC-DAD

Guo

et al. 2020

Molecules

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The herbal pair of Coptidis Rhizoma (CR) and Euodiae Fructus (EF) is a classical traditional Chinese medicine formula used for treating gastro-intestinal disorders. In this study, we established a systematic method for chemical profiling and quantification analysis of the major constituents in the CR-EF herbal pair. A method of ultra high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) for qualitative analysis was developed. Sixty-five compounds, including alkaloids, phenolics, and limonoids, were identified or tentatively assigned by comparison with reference standards or literature data. The UHPLC fingerprints of 19 batches of the CR-EF herbal pair samples were obtained and the reference fingerprint chromatograms were established. Furthermore, nine compounds among 24 common peaks of fingerprints were considered as marker components, which either had high contents or significant bioactivities, were applied to quality control of the CR-EF herbal pair by quantitative analysis. This UHPLC-DAD analysis method was validated by precision, linearity, repeatability, stability, recovery, and so on. The method was simple and sensitive, and thus reliable for quantitative and chemical fingerprint analysis for the quality evaluation and control of the CR-EF herbal pair and related traditional Chinese medicines.

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Section: Resultsmentioning

confidence: 99%

Simultaneous Qualitative and Quantitative Evaluation of the Coptidis Rhizoma and Euodiae Fructus Herbal Pair by Using UHPLC-ESI-QTOF-MS and UHPLC-DAD

Guo

et al. 2020

Molecules

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“…Berberine, an alkaloid derived from Berberis species herbs, ameliorated autophagic flux and removed tau aggregates in AD mice, recovering memory and spatial learning (Chen et al, 2020). Intriguingly, it was also effective in removal of abnormal ubiquitinated TDP-43 deposits in frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (ALS) by autophagy (Ling et al, 2013;Chang et al, 2016).…”

Section: Alkaloidsmentioning

confidence: 99%

“…Silymarin Forebrain ischemia-rat 7 mg/kg-reduced autophagic flux Hirayama et al, 2016 Baicalein PD-Rotenone injected mice 100 mg/kg i.p. for 5 weeks-LC3 activation Kuang et al, 2017 Alkaloids Berberine AD and HD mice 40 mg/kg-Akt inhibition Jiang et al, 2015;Wang et al, 2017. Spinal cord injury-rat 20 mg/kg-AMPK activation Chen et al, 2020 Caffeine PD mice 1 g/L for 3 months-LC3II-LAMP2A activation Luan et al, 2018 Terpenes Ginaton Brain ischemia mice 50 mg/kg for 14 days-AMPK activation Tian et al, 2017;Li et al, 2019b Carotenoids Traumatic brain injury mice 50-200 mg/kg i.g.-Beclin 1-LC3 activation Zhang et al, 2017 Others β-Asarone AD-APP/PS1 mice 10 mg/kg-Beclin 1-Akt reduction Melatonin SAH rats 5-10 mg/kg i.v.-abnormal autophagy decrease Cao et al, 2017;Shi et al, 2018 Trehalose Batten disease mice 2% oral-TFEB activation He et al, 2016;Holler et al, 2016;Tien et al, 2016;Palmieri et al, 2017 AD, PD, FTD mice an antagonist of NF-kB signaling by sirtuin 1 deacetylase (Nopparat et al, 2017).…”

Section: Polyphenolsmentioning

confidence: 99%

Natural Compounds and Autophagy: Allies Against Neurodegeneration

Stacchiotti

Corsetti

2020

Front. Cell Dev. Biol.

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Prolonging the healthy life span and limiting neurological illness are imperative goals in gerontology. Age-related neurodegeneration is progressive and leads to severe diseases affecting motility, memory, cognitive function, and social life. To date, no effective treatments are available for neurodegeneration and irreversible neuronal loss. Bioactive phytochemicals could represent a natural alternative to ensure active aging and slow onset of neurodegenerative diseases in elderly patients. Autophagy or macroautophagy is an evolutionarily conserved clearing process that is needed to remove aggregateprone proteins and organelles in neurons and glia. It also is crucial in synaptic plasticity. Aberrant autophagy has a key role in aging and neurodegeneration. Recent evidence indicates that polyphenols like resveratrol and curcumin, flavonoids, like quercetin, polyamine, like spermidine and sugars, like trehalose, limit brain damage in vitro and in vivo. Their common mechanism of action leads to restoration of efficient autophagy by dismantling misfolded proteins and dysfunctional mitochondria. This review focuses on the role of dietary phytochemicals as modulators of autophagy to fight Alzheimer's and Parkinson's diseases, fronto-temporal dementia, amyotrophic lateral sclerosis, and psychiatric disorders. Currently, most studies have involved in vitro or preclinical animal models, and the therapeutic use of phytochemicals in patients remains limited.

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“…They are primarily found in Solanaceae (nightshades), Papaveraceae (poppies family), Ranunculaceae (buttercups), and Amaryllidaceae (amaryllis) plant families [ 116 ]. A variety of phytochemicals belonging to the alkaloid group has proven beneficial effects in several models of neurodegeneration, among which berberine (an isoquinoline alkaloid) and caffeine (a xanthine alkaloid) are worth mentioning [ 60 , 67 , 117 , 118 , 119 , 120 , 121 ].…”

Section: An Overview Of Neuroprotective Phytochemical Classesmentioning

confidence: 99%

“…Similar to quercetin, curcumin exerts anti-fibrillogenic effects and counteracts the aggregation of tau and Aβ through mTOR-dependent autophagy activation [ 223 , 224 ]. Similar effects in AD mice models are provided by berberine, which reduces hyperphosphorylation of tau and promotes its clearance through autophagy induction via Akt/GSK3-β and PI3K/Beclin-1 pathways [ 118 ]. Berberine, through autophagy induction, also prevents the cognitive decline and reduces Aβ plaque deposition in mice AD models [ 119 ].…”

Section: Phytochemicals and Proteostasismentioning

confidence: 99%

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

et al. 2020

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Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders. Generally, the neuroprotective effects of bioactive compounds belonging to different phytochemical classes are attributed to antioxidant, anti-aggregation, and anti-inflammatory activity along with the restoration of mitochondrial homeostasis and targeting alterations of cell-clearing systems. Far from being independent, these multi-target effects represent interconnected events that are commonly implicated in the pathogenesis of most neurodegenerative diseases, independently of etiology, nosography, and the specific misfolded proteins being involved. Nonetheless, the increasing amount of data applying to a variety of neurodegenerative disorders joined with the multiple effects exerted by the wide variety of plant-derived neuroprotective agents may rather confound the reader. The present review is an attempt to provide a general guideline about the most relevant mechanisms through which naturally occurring agents may counteract neurodegeneration. With such an aim, we focus on some popular phytochemical classes and bioactive compounds as representative examples to design a sort of main highway aimed at deciphering the most relevant protective mechanisms which make phytochemicals potentially useful in counteracting neurodegeneration. In this frame, we emphasize the potential role of the cell-clearing machinery as a kernel in the antioxidant, anti-aggregation, anti-inflammatory, and mitochondrial protecting effects of phytochemicals.

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Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance

Cited by 98 publications

References 52 publications

Simultaneous Qualitative and Quantitative Evaluation of the Coptidis Rhizoma and Euodiae Fructus Herbal Pair by Using UHPLC-ESI-QTOF-MS and UHPLC-DAD

Simultaneous Qualitative and Quantitative Evaluation of the Coptidis Rhizoma and Euodiae Fructus Herbal Pair by Using UHPLC-ESI-QTOF-MS and UHPLC-DAD

Natural Compounds and Autophagy: Allies Against Neurodegeneration

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

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