Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis

Liu, Yunxin; Hua, Weiwei; Yao, Li; Xian, Xirui; Zhao, Zheng; Liu, Chao; Zou, Jianjun; Li, Jun; Fang, Xianjun; Zhu, Yubing

doi:10.1016/j.bcp.2019.113776

Cited by 87 publications

(69 citation statements)

References 40 publications

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“…eMT can significantly enhance the migratory ability of cancer cells, including breast cancer cells, which can lead to tumor migration and invasion (9); therefore, drugs targeting the eMT pathway may reduce mortality in patients with breast cancer (37). in recent years, a number of studies have reported that traditional Chinese medicine displays significant anticancer effects (38)(39)(40). aM, which is an important component of the qi-supplementing formula, is widely used in china (41) and the main extract of aM is aPS.…”

Section: Discussionmentioning

confidence: 99%

Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway

Yang

Sun

et al. 2020

Mol Med Report

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epithelial-mesenchymal transition (eMT) serves an important role in tumor migration and invasion. Astragalus polysaccharide (aPS), which is the main component of the traditional chinese medicine Astragalus membranaceus, has been identified to display an antitumor effect. However, the effects and mechanisms of aPS during breast cancer migration and invasion are not completely understood. The present study investigated whether aPS inhibited breast cancer migration and invasion by modulating the eMT pathway. an MTT assay and a Ki67 immunofluorescence staining assay demonstrated that aPS inhibited the proliferation of breast cancer cells. The results of the wound healing and Transwell Matrigel invasion assays suggested that aPS decreased the migration and invasion of breast cancer cells. The western blotting and immunofluorescence analyses further demonstrated that aPS had a regulatory effect on eMT-related molecules. aPS decreased the expression levels of Snail and vimentin, but increased e-cadherin expression. aPS also downregulated Wnt1, β-catenin and downstream target expression. additionally, the present results suggested that aPS decreased the proliferation, and eMT-mediated migration and invasion of cells by inhibiting the Wnt/β-catenin signaling pathway. The present study suggested that aPS may serve as a promising therapeutic agent for breast cancer.

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Section: Discussionmentioning

confidence: 99%

Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway

Yang

Sun

et al. 2020

Mol Med Report

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“…It has significant antibacterial, antiarrhythmic, antihypertensive and blood lipid regulating effects [11]. A large number of studies have shown that berberine has a significant antitumor effect and can participate in the antitumor process of many kinds of cancer, such as liver cancer [12], lung cancer [13], colon cancer [14], esophageal cancer [15], leukemia [16], and so on. Berberine can inhibit tumor progression by inhibiting tumor angiogenesis, promoting apoptosis, blocking invasion and metastasis, reversing drug resistance, etc.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells

Zou

Pei

et al. 2021

J. Cancer

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Background: Berberine, as an alkaloid, has a significant antitumor effect, but its mechanism in tumor metabolism, especially the Warburg effect has not been elucidated. Objectives: To study the molecular mechanism of berberine regulating the Warburg effect in ovarian cancer cells. Methods: Treatment by berberine in SKOV3 and 3AO cells or inhibited by miR-145 inhibitor transfection in berberine-treated cells to examine the changes in HK2 expression, glucose consumption and lactate production. The methylation status in the promoter region of pre-miR-145 gene was examined by bisulfite sequencing. Dual-luciferase reporter assay was conducted to verify the direct binding of miR-145 to HK2. Finally, the expression of TET3 in ovarian cancer was investigated by quantitative real-time PCR and immunohistochemistry. Results: We found berberine inhibited the Warburg effect by up-regulating miR-145, miR-145 targeted HK2 directly. Berberine increased the expression of miR-145 by promoting the expression of TET3 and reducing the methylation level of the promoter region of miR-145 precursor gene. We further found that TET3 expression was negatively correlated with clinical stage and pathological grade. Conclusions: Our results revealed berberine increased the TET3-mediated demethylation and promoted the suppression of miR-145 on HK2 to antagonize the Warburg effect of ovarian cancer cells.

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“…Besides, BBR leaves great antitumor effects on multiple types of cancer such as breast cancer, 69 bladder cancer, 70 hepatocarcinoma, 71 and colon cancer. 72 BBR exerts its antitumor activity by inhibiting proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis and metastasis ( Figure 1). According to the studies, BBR influences several intracellular targets participating in cell cycle, apoptosis, and different pathways of signal transmission.…”

Section: Cancer Therapymentioning

confidence: 99%

Berberine: A novel therapeutic strategy for cancer

et al. 2020

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Cancer, even currently, is one of the main reasons for mortality and morbidity, worldwide. In recent years, a great deal of effort has been made to find efficient therapeutic strategies for cancer, however, particularly with regards to side effects and the possibility of complete remission. Berberine (BBR) is a nature‐driven phytochemical component originated from different plant groups such as Berberis vulgaris, Berberis aquifolium, and Berberis aristata. BBR is a well‐known nutraceutical because of its wide range of pharmacological activities including anti‐inflammatory, antidiabetic, antibacterial, antiparasitic, antidiarrheal, antihypertensive, hypolipidemic, and fungicide. In addition, it exhibits inhibitory effects on multiple types of cancers. In this review, we have elaborated on the anticancer effects of BBR through the regulation of different molecular pathways such as: inducing apoptosis, autophagy, arresting cell cycle, and inhibiting metastasis and invasion.

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Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis

Cited by 87 publications

References 40 publications

Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway

Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway

Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells

Berberine: A novel therapeutic strategy for cancer

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