Renovation construction is employed for maintaining the long-term performance of buildings. For the occupants, the building users, renovation contributes to the acceptable levels of convenience and quality of the buildings. However, if the operation continues during the renovation for an area containing several buildings, such as a university campus, the impacts on the occupants are unavoidable. The complicated schedule plan is needed due to the various types of buildings and types of renovation under limited resources. The goal of this study is to build a model that can help the planners to make the renovation schedule plan. Taking a university campus as an example, the occupants’ convenience rate and the long-term quality of the building are analyzed in this paper. Based on the key attributes of building renovation, this study proposes a model integrating the genetic algorithm and simulation to provide the optimal schedule plan to the planners. The model is demonstrated by an application case of a university campus of 11 buildings remaining in operation. It helps the university maintain a good level of long-term performance of buildings.