Beryllium in urine by ICP-MS: a comparison of low level exposed workers and unexposed persons

Morton, Jackie; Leese, Elizabeth; Cotton, Richard; Warren, Nicholas; Cocker, John

doi:10.1007/s00420-010-0587-2

Cited by 13 publications

(7 citation statements)

References 27 publications

(29 reference statements)

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“…In the HMI configuration, an instrumental quantification limit of 2 ng L −1 was calculated. These figures of merits are slightly lower than those reported by Morton et al [8] using a quadrupole-based ICP-MS equipped with HPi and Xi cones and a silver screen on the torch, which were 2 and 6 ng L −1 , for the detection and quantification limits, respectively.…”

Section: Effect Of Aerosol Dilution On Beryllium Detectioncontrasting

confidence: 59%

“…Several research groups [8,13,14] have proposed numerous elements as potential IS for low masses (Li, Sc, Ga, Y, and Rh) in clinical analysis of metals to overcome signal attenuation. As noted by Finley-Jones et al [21], the choice of an ideal IS should be based on the various conditions: (1) it should be absent from the sample, (2) it should have similarity in mass and, (3) in ionization potential.…”

Section: Choice Of An Internal Standardmentioning

confidence: 99%

“…Several approaches have been proposed to overcome these analytical problems. Of these, the use of internal standards and matrix-matched calibration can be used for beryllium determination in specific human tissues and fluids [8,[13][14][15][16]. However, a single approach does not provide the versatility required to enable the proper quantification of beryllium in human tissues.…”

Section: Introductionmentioning

confidence: 99%

“…As inhalation is a primary route of the occupational exposure to Be, assessment of its concentration through aerosol sampling and swipes is commonly performed to detect exposure to Be in the workplace [5,6]. Additionally, biological indicators, such as hair and/or urine could be used to confirm current exposure [7,8] but do not necessarily provide information regarding past ones. According to Publication 30 of the International Commission on Radiological Protection regarding the systemic metabolic model, 40% of the Be circulated in blood is deposited in mineral bone while 20% is uniformly distributed among all other organs and tissues in the body [9].…”

Section: Introductionmentioning

confidence: 99%

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Detection of beryllium in digested autopsy tissues by inductively coupled plasma mass spectrometry using a high matrix interface configuration

et al. 2012

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This article describes a robust methodology using the combination of instrumental design (high matrix interface-HMI), sample dilution and internal standardization for the quantification of beryllium (Be) in various digested autopsy tissues using inductively coupled plasma mass spectrometry. The applicability of rhodium as a proper internal standard for Be was demonstrated in three types of biological matrices (i.e., femur, hair, lung tissues). Using HMI, it was possible to achieve instrumental detection limits and sensitivity of 0.6 ng L(-1) and 157 cps L ng(-1), respectively. Resilience to high salt matrices of the HMI setup was also highlighted using bone mimicking solution ([Ca(2+)] = 26 to 1,400 mg L(-1)), providing a 14-fold increase in tolerance and a 2.7-fold decrease in method detection limit compared to optimized experimental conditions obtained without the HMI configuration. Precision of the methodology to detect low levels of Be in autopsy samples was demonstrated using hair and blood certified reference materials. Be concentration ranging from 0.015 to 255 μg kg(-1) in autopsy samples obtained from the U.S. Transuranium and Uranium Registries were measured using the methodology presented.

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Section: Effect Of Aerosol Dilution On Beryllium Detectioncontrasting

confidence: 59%

Section: Choice Of An Internal Standardmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Detection of beryllium in digested autopsy tissues by inductively coupled plasma mass spectrometry using a high matrix interface configuration

et al. 2012

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“…In 1983, inductively coupled plasma mass spectrometry (ICP-MS) was introduced as a commercially available system with great progress and currently used for a wide range of applications [ 26 ]. Today, ICP-MS has become one of the most effective techniques for simultaneous determination of multiple trace or ultra-trace elements (e.g., REEs) in human biological samples, high-purity materials, and geological samples [ 1 , 27 , 28 , 29 ]. Among several analytical techniques used to determine the concentration of REEs in urine, ICP-MS technology has the rapid, quasi-simultaneous, multi-element detection capabilities, low detection limits and high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Direct Quantification of Rare Earth Elements Concentrations in Urine of Workers Manufacturing Cerium, Lanthanum Oxide Ultrafine and Nanoparticles by a Developed and Validated ICP-MS

Zheng

et al. 2016

IJERPH

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Rare earth elements (REEs) have undergone a steady spread in several industrial, agriculture and medical applications. With the aim of exploring a sensitive and reliable indicator of estimating exposure level to REEs, a simple, accurate and specific ICP-MS method for simultaneous direct quantification of 15 REEs (89Y, 139La, 140Ce, 141Pr, 146Nd, 147Sm, 153Eu, 157Gd, 159Tb, 163Dy, 165Ho, 166Er, 169Tm, 172Yb and 175Lu) in human urine has been developed and validated. The method showed good linearity for all REEs in human urine in the concentrations ranging from 0.001–1.000 μg∙L−1 with r2 > 0.997. The limits of detection and quantification for this method were in the range of 0.009–0.010 μg∙L−1 and 0.029–0.037 μg∙L−1, the recoveries on spiked samples of the 15 REEs ranged from 93.3% to 103.0% and the relative percentage differences were less than 6.2% in duplicate samples, and the intra- and inter-day variations of the analysis were less than 1.28% and less than 0.85% for all REEs, respectively. The developed method was successfully applied to the determination of 15 REEs in 31 urine samples obtained from the control subjects and the workers engaged in work with manufacturing of ultrafine and nanoparticles containing cerium and lanthanum oxide. The results suggested that only the urinary levels of La (1.234 ± 0.626 μg∙L−1), Ce (1.492 ± 0.995 μg∙L−1), Nd (0.014 ± 0.009 μg∙L−1) and Gd (0.023 ± 0.010 μg∙L−1) among the exposed workers were significantly higher (p < 0.05) than the levels measured in the control subjects. From these, La and Ce were the primary components, and accounted for 88% of the total REEs. Lanthanum comprised 27% of the total REEs while Ce made up the majority of REE content at 61%. The remaining elements only made up 1% each, with the exception of Dy which was not detected. Comparison with the previously published data, the levels of urinary La and Ce in workers and the control subjects show a higher trend than previous reports.

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Beryllium und seine anorganischen Verbindungen – Bestimmung von Beryllium in Urin mittels Atomabsorptionsspektrometrie [Biomonitoring Methods in German language, 2017]

Paul

Budnik

Göen

et al. 2017

The MAK‐Collection for Occupational Health and Safety

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The working group „Analyses in Biological Materials“ of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the present biomonitoring method. This procedure describes a method for the determination of beryllium in urine by means of atomic absorption spectrometry using the graphite furnace technique with a pyrolytically coated graphite tube and Zeeman background correction. The acidified samples are homogenized and injected into the graphite tube without further sample preparation using an autosampler. Magnesium nitrate is used as a matrix modifier. After drying, pyrolysis and atomization, the absorbance is measured at 234.9 nm. The beryllium concentration is quantified using either a calibration curve (method I) or the standard addition method (method II). The method was extensively validated and the reliability data were confirmed by independent laboratories, which have established and cross‐checked the whole procedure.

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Beryllium in urine by ICP-MS: a comparison of low level exposed workers and unexposed persons

Abstract: A sensitive and reliable analytical method was developed for urinary beryllium by ICP-MS. The workers in this study were exposed to beryllium at very low levels.

Cited by 13 publications

References 27 publications

Detection of beryllium in digested autopsy tissues by inductively coupled plasma mass spectrometry using a high matrix interface configuration

Detection of beryllium in digested autopsy tissues by inductively coupled plasma mass spectrometry using a high matrix interface configuration

Direct Quantification of Rare Earth Elements Concentrations in Urine of Workers Manufacturing Cerium, Lanthanum Oxide Ultrafine and Nanoparticles by a Developed and Validated ICP-MS

Beryllium und seine anorganischen Verbindungen – Bestimmung von Beryllium in Urin mittels Atomabsorptionsspektrometrie [Biomonitoring Methods in German language, 2017]

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