Best of Milan 2017—repair of the emphysematous lung: mesenchymal stromal cell and matrix

Polverino, Francesca

doi:10.21037/jtd.2017.11.41

Cited by 2 publications

(2 citation statements)

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“…Intravenous administration of exosomes may result in aggregation or clumping in the injured microcirculation, and there is a higher risk of mutagenicity and oncogenicity. This issue does not arise when using nebulizers, specifically nebulized MSCs-Exo [ 149 ]. Previously, this review discussed the use of aerosolized MSCs due to their ability to target the lungs in ways intravenous administration is unable to.…”

Section: Pre-clinical Studiesmentioning

confidence: 99%

“…Previously, this review discussed the use of aerosolized MSCs due to their ability to target the lungs in ways intravenous administration is unable to. Aerosol MSC-based therapy is a novel strategy that is capable of enhancing reparative and regenerative processes in both chronic and acute lung injuries [ 149 ]. Researchers and biomedical disciplines are beginning to investigate the tolerance of aerosol inhalation of mesenchymal stem cell exosomes (see Table 4 ).…”

Section: Pre-clinical Studiesmentioning

confidence: 99%

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State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery

Brave

MacLoughlin

2020

IJMS

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Respiratory and pulmonary diseases are among the leading causes of death globally. Despite tremendous advancements, there are no effective pharmacological therapies capable of curing diseases such as COPD (chronic obstructive pulmonary disease), ARDS (acute respiratory distress syndrome), and COVID-19. Novel and innovative therapies such as advanced therapy medicinal products (ATMPs) are still in early development. However, they have exhibited significant potential preclinically and clinically. There are several longitudinal studies published, primarily focusing on the use of cell therapies for respiratory diseases due to their anti-inflammatory and reparative properties, thereby hinting that they have the capability of reducing mortality and improving the quality of life for patients. The primary objective of this paper is to set out a state of the art review on the use of aerosolized MSCs and their potential to treat these incurable diseases. This review will examine selected respiratory and pulmonary diseases, present an overview of the therapeutic potential of cell therapy and finally provide insight into potential routes of administration, with a focus on aerosol-mediated ATMP delivery.

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Section: Pre-clinical Studiesmentioning

confidence: 99%

Section: Pre-clinical Studiesmentioning

confidence: 99%