This chapter provides a synthetic overview of research activities and main outcomes of members of the scientific-disciplinary sector “SECS-S/02—Statistica per la Ricerca Sperimentale e Tecnologica” at the University of Naples Federico II, in the decade 2013–2023. Research activities of the group focus on modern statistical problems arising in the field of experimental sciences (statistics and probability calculus, design, and analysis of experiments), notably in engineering (reliability, statistical quality control). The main fields of application concern technology, safety, environment, territory, production processes, products, and natural resources.