Bestimmung renal eliminierten Benzhydrols und dessen Glucuronids. Potentielle Metaboliten von Diphenylmethyl�ther- und Diphenylmethylamin-Derivaten

Dell, H. D.; Fiedler, J.

doi:10.1007/bf00447348

Cited by 13 publications

(4 citation statements)

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“…The most common biological fluids used for the analysis of antihistamines and their metabolites for clinical and forensic toxicology purposes are whole blood, plasma/serum and urine. Blood, plasma and serum can often be interchanged in many methods, while when urine samples are analyzed a hydrolysis step of antihistamine glucuronides is required before the extraction procedure (Dell and Fiedler, ; Maurer and Pfleger, ). Immunoassay methods performed for the determination of certain antihistamines are normally applied in plasma or serum (Tables ).…”

Section: Analytical Methods For the Determination Of Antihistamines Imentioning

confidence: 99%

“…Antihistamines were determined by TLC after previous extraction from biological samples (plasma, serum and urine) with organic solvents (Fike and Sunshine, ; Ackermann et al , ; Hassan et al , ) or after proteolysis in the case of plasma or serum (Pandya et al , ). Hydrolysis of urine samples with β ‐glucuronidase (Dell and Fiedler, ) can also be performed. Combinations of Dragendorff's, Mandelin's and iodoplatinate spray reagents or fluorescence and ultraviolet detection of the drugs on the TLC plates have been used (Table ).…”

Section: Chromatographic Techniquesmentioning

confidence: 99%

“…Ali ( (Fusari et al, 1975;Argekar and Powar, 1999;Makhija and Vavia, 2001;Subramaniyan and Das, 2004;Czerwinska et al, 2013;Lamie and Monir, 2016 Hassan et al, 2002) or after proteolysis in the case of plasma or serum (Pandya et al, 1996). Hydrolysis of urine samples with β-glucuronidase (Dell and Fiedler, 1977) can also be performed. Combinations of Dragendorff's, Mandelin's and iodoplatinate spray reagents or fluorescence and ultraviolet detection of the drugs on the TLC plates have been used (Table 3).…”

Section: Chromatographic Techniquesmentioning

confidence: 99%

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Bioanalysis of antihistamines for clinical or forensic purposes

Katselou

Papoutsis

Νικολάου

et al. 2016

Biomedical Chromatography

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Antihistamines are a class of drugs that inhibit the action of histamine and are used to alleviate symptoms associated with allergic reactions, but some of them can cause side effects, the most unpleasant and dangerous of which are the sedative effects that may hinder important psychological functions and impair skilled performance. These side effects could decrease safety in certain common and critical tasks, such as driving or operating machinery, leading to accidents. Antihistamines can also cause intoxications, sometimes lethal, especially when co-administered with alcohol or other sedative drugs. Thus, the development of analytical methods for their determination in biological fluids is considered to be useful for the investigation of clinical and forensic cases. These methodologies could also be used for pharmacokinetic studies. Several liquid and a few gas chromatographic methods have been developed for the determination of antihistamines in biological matrices after proper pretreatment procedures. This article reviews the published analytical methodologies that were gathered through the search in PubMed database and the recent developments on isolation or determination of antihistamines in biological materials. Current trends and future perspectives on bioanalysis of antihistamines are also discussed. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Analytical Methods For the Determination Of Antihistamines Imentioning

confidence: 99%

Section: Chromatographic Techniquesmentioning

confidence: 99%

Section: Chromatographic Techniquesmentioning

confidence: 99%

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Bioanalysis of antihistamines for clinical or forensic purposes

Katselou

Papoutsis

Νικολάου

et al. 2016

Biomedical Chromatography

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“…The methods for the analysis of cinnarizine described in the literature (2)(3)(4)(5)(6) exhibit several disadvantages. Dell and Fiedler GC method with a low recovery of about 60% and a quite high detection limit of 10 ng/ml.…”

Section: Determination Of Cinnarizine In Whole Blood and Plasma By Rementioning

confidence: 99%

Determination of Cinnarizine in Whole Blood and Plasma by Reversed Phase HFLC and its Application to a Pharmacokinetic Study

Puttemans

Bogaert

Hoogewijs

et al. 1984

Journal of Liquid Chromatography

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Journal of Liquid ChromatographyPublication details, including instructions for authors and subscription information:ABSTRACT Cinnarizine is determined in whole blood and plasma by reversed phase HPLC on a RP-18 stationary phase. The one-step extraction is performed with a chloroform/hexane (2/3) mixture. A high recovery of 91% and a detection limit of 2 ng/rnl are obtained as well as a good precision. Pharmacokinetic parameters found are in accordance with data cited in literature.The internal standard is meclozine.

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