Beta-adrenergic receptor blocker propranolol triggers anti-tumor immunity and enhances irinotecan therapy in mice colorectal cancer

Lin, Yining; Liu, Yiming; Gao, Zhenhua; Jing, Dongquan; Bi, Ran; Cui, Xinmeng; Cao, Qiu-Hua; Zhao, Qixiang; Gao, Rui; Su, Yumin; Liu, Siliang; Zhao, Mingrui; Yang, Yong; Chen, Anqi; Dai, Beiying; Gao, Xinghua

doi:10.1016/j.ejphar.2023.175718

Cited by 7 publications

(2 citation statements)

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“…Propranolol as a β1 and β2 adrenergic receptor blocker inhibits AOM DSS induced tumor development [42]. Similarly, cancers cells can have β adrenergic receptors and respond to the presence of catecholamines produced during stress.…”

Section: Discussionmentioning

confidence: 99%

Structural enrichment attenuates colitis-associated colon cancer

Sykes,

Solanki,

Chukkapalli

et al. 2024

Preprint

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Colorectal cancer (CRC) is a major public health concern and disproportionately impacts racial/ethnic minority populations in the US. Animal models are helpful in examining human health disparities because many stress-induced human health conditions can be recapitulated using mouse models. Azoxymethane (AOM)/dextran sodium sulfate (DSS) treatment can be used to model colitis-associated cancers. While colitis-associated cancers account for only 2% of colon cancers, the AOM/DSS model is useful for examining links between inflammation, immunity, and colon cancer. Mice were housed in enriched and impoverished environments for 1-month prior to behavioral testing. Following behavioral testing the mice were subjected to the AOM/DSS model. While our analysis revealed no significant behavioral variances between the impoverished and enriched housing conditions, we found significant effects in tumorigenesis. Enriched mice had fewer tumors and smaller tumor volumes compared to impoverished mice. African Americans are at higher risk for early onset colorectal cancers in part due to social economic status. Furthermore, housing conditions and environment may reflect social economic status. Research aimed at understanding links between social economic status and colorectal cancer progression is important for eliminating disparities in health outcomes.

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Section: Discussionmentioning

confidence: 99%

Structural enrichment attenuates colitis-associated colon cancer

Sykes,

Solanki,

Chukkapalli

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Gene variants of PTGS1 inflammatory pathway were significantly associated with increased risk of CRC, and PTGS1 gene polymorphisms were identified as a risk factor for CRC. The beta2 adrenergic receptor ( ADRB2 ) is positively associated with T-cell exhaustion features in various tumors ( Lin et al, 2023 ). T cells are crucial anti-tumor lymphocytes, and the exhaustion of these cells is frequently linked to the malignant progression of malignancies.…”

Section: Discussionmentioning

confidence: 99%