1979
DOI: 10.1111/j.1365-2125.1979.tb00954.x
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Beta‐adrenoceptor blocking drugs and diuretics in hypertension.

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Cited by 5 publications
(3 citation statements)
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“…This study confirms the theoretical benefit of combining the two drugs so that the addition of long‐acting propranolol has counteracted the signficant hypokalaemia induced by bendrofluazide. In view of the possible risks associated with hypokalemia, including serious cardiac arrhythmias 7 , the combination seems particularly appropriate and helps reduce the need for higher doses of diuretic which, in any case, are unlikely to further lower the blood pressure 3 .…”
Section: Discussionmentioning
confidence: 99%
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“…This study confirms the theoretical benefit of combining the two drugs so that the addition of long‐acting propranolol has counteracted the signficant hypokalaemia induced by bendrofluazide. In view of the possible risks associated with hypokalemia, including serious cardiac arrhythmias 7 , the combination seems particularly appropriate and helps reduce the need for higher doses of diuretic which, in any case, are unlikely to further lower the blood pressure 3 .…”
Section: Discussionmentioning
confidence: 99%
“…The beta‐adrenoceptor blocking drug propranolol is an effective antihypertensive drug which is accepted as first line therapy in hypertension 1 . In patients who are not fully controlled by propranolol alone, rather than increase the dose, the addition of a low dose of diuretic can usually achieve a greater antihypertensive effect 2,3 . Propranolol and bendrofluazide have been successfully used in this way when administered twice daily 4 .…”
Section: Introductionmentioning
confidence: 99%
“…Secondly, when there is more than one cause present in a particular patient, combination therapy, often with a f8-adrenoceptor blocker and diuretic, may be found useful, particularly to improve patient compliance with dosage regimens. Moreover, Baber & Dawes (1979) demonstrated that patients who fail to respond to f3-adrenoceptor blockers or diuretics are often found to respond adequately when both drugs are given concurrently.…”
Section: Discussionmentioning
confidence: 99%