Beta- and Novel Delta-Coronaviruses Are Identified from Wild Animals in the Qinghai-Tibetan Plateau, China

Zhu, Wentao; Yang, Jing; Lu, Shan; Lan, Ruiting; Jin, Dong; Luo, Xue; Pu, Ji; Wu, Shusheng; Xu, Jianguo

doi:10.1007/s12250-020-00325-z

Cited by 25 publications

(25 citation statements)

References 38 publications

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“…Moreover, broad phenotypic alterations and potential dysfunctions were still prominent in those T cells in individuals clinically recovered from COVID-19 (Yang et al . 2020a , b ). It is still unknown, after being recovered for a long time, whether the altered non-specific T cell responses could bounce back and whether the specific T cell responses are sustainable.…”

Section: Introductionmentioning

confidence: 97%

Alterations in Phenotypes and Responses of T Cells Within 6 Months of Recovery from COVID-19: A Cohort Study

et al. 2021

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The COVID-19 pandemic, caused by the SARS-CoV-2 infection, is a global health crisis. While many patients have clinically recovered, little is known about long-term alterations in T cell responses of COVID-19 convalescents. In this study, T cell responses in peripheral blood mononuclear cells of a long-time COVID-19 clinically recovered (20-26 weeks) cohort (LCR) were measured via flow cytometry and ELISpot. The T cell responses of LCR were comparatively analyzed against an age and sex matched short-time clinically recovered (4-9 weeks) cohort (SCR) and a healthy donor cohort (HD). All volunteers were recruited from Wuhan Jinyintan Hospital, China. Phenotypic analysis showed that activation marker PD-1 expressing on CD4 ? T cells of LCR was still significantly lower than that of HD. Functional analysis indicated that frequencies of Tc2, Th2 and Th17 in LCR were comparable to those of HD, but Tc17 was higher than that of HD. In LCR, compared to the HD, there were fewer IFN-c producing T cells but more IL-2 secreting T cells. In addition, the circulating Tfh cells in LCR were still slightly lower compared to HD, though the subsets composition had recovered. Remarkably, SARS-CoV-2 specific T cell responses in LCR were comparable to that of SCR. Collectively, T cell responses experienced long-term alterations in phenotype and functional potential of LCR cohort. However, after clinical recovery, SARS-CoV-2 specific T cell responses could be sustained at least for six months, which may be helpful in resisting re-infection.

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Section: Introductionmentioning

confidence: 97%

Alterations in Phenotypes and Responses of T Cells Within 6 Months of Recovery from COVID-19: A Cohort Study

et al. 2021

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“…The mutations of viruses are common and, as a consequence, the SARS-CoV-2 can acquire mutations with fitness advantages and immunological resistance [1,25]. Several researchers have devoted time to study evolutionary transitions in order to ensure effectiveness of the vaccines and immunotherapeutic interventions [1,[26][27][28][29]. A new variant of the SARS-CoV-2 virus has been detected in England, and is the VOC-202012/01 of lineage B.1.1.7.…”

Section: Introductionmentioning

confidence: 99%

“…It has been found that the SARS-CoV-2 is mutating, and its transmission is more efficient [26,[73][74][75]. There is a growing literature about new variants of the SARS-CoV-2, but it is, of course, not clear what further variants will occur in the future [1,[26][27][28][29]. For instance, using analysis of the frequency of the 614D and 614G variants, over time, it has been suggested that locations that reported 614D viruses early in the pandemic were often later dominated by 614G viruses [1].…”

Section: Introductionmentioning

confidence: 99%

Impact of a New SARS-CoV-2 Variant on the Population: A Mathematical Modeling Approach

González-Parra

Martínez‐Rodríguez

Micó

2021

MCA

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Several SARS-CoV-2 variants have emerged around the world, and the appearance of other variants depends on many factors. These new variants might have different characteristics that can affect the transmissibility and death rate. The administration of vaccines against the coronavirus disease 2019 (COVID-19) started in early December of 2020 and in some countries the vaccines will not soon be widely available. For this article, we studied the impact of a new more transmissible SARS-CoV-2 strain on prevalence, hospitalizations, and deaths related to the SARS-CoV-2 virus. We studied different scenarios regarding the transmissibility in order to provide a scientific support for public health policies and bring awareness of potential future situations related to the COVID-19 pandemic. We constructed a compartmental mathematical model based on differential equations to study these different scenarios. In this way, we are able to understand how a new, more infectious strain of the virus can impact the dynamics of the COVID-19 pandemic. We studied several metrics related to the possible outcomes of the COVID-19 pandemic in order to assess the impact of a higher transmissibility of a new SARS-CoV-2 strain on these metrics. We found that, even if the new variant has the same death rate, its high transmissibility can increase the number of infected people, those hospitalized, and deaths. The simulation results show that health institutions need to focus on increasing non-pharmaceutical interventions and the pace of vaccine inoculation since a new variant with higher transmissibility, such as, for example, VOC-202012/01 of lineage B.1.1.7, may cause more devastating outcomes in the population.

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“…Regarding mutations, SARS-CoV-2 could acquire mutations with fitness advantages and immunological resistance [71]. Therefore, studying evolutionary transitions is important to ensure effectiveness of the vaccines and immunotherapeutic interventions [151, 50, 104, 157, 71]. It has been stateded that not only is the efficacy of the vaccine important, but whether a vaccine reduces infection and transmission as well as disease progression [69].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, it has been found that the SARS-CoV-2 is mutating and its transmission is more efficient [151, 98, 33, 77]. There is a growing literature about mutations of the SARS-CoV-2, but it is not clear what further mutations could occur in the near future [151, 50, 104, 157, 71].…”

Section: Introductionmentioning

confidence: 99%

Analysis of key factors of a SARS-CoV-2 vaccination program: A mathematical modeling approach

Martínez‐Rodríguez

González-Parra

Micó

2021

Preprint

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The administration of vaccines against the coronavirus disease 2019 (COVID-19) just started in early December of 2020. Currently, there are only a few approved vaccines, each with different efficacies and mechanisms of action. Moreover, vaccination programs in different regions may vary due to differences in implementation, for instance, simply the availability of the vaccine. In this article, we study the impact of the pace of vaccination and the intrinsic efficacy of the vaccine on prevalence, hospitalizations, and deaths related to the SARS-CoV-2 virus. Then we study different potential future scenarios regarding the burden of the COVID-19 pandemic in the near future. We construct a compartmental mathematical model and use computational methodologies to study these different scenarios. Thus, we are able identify some key factors to reach the aims of the vaccination programs. We use some metrics related to the outcomes of the COVID-19 pandemic in order to assess the impact of the efficacy of the vaccine and the pace of the vaccine inoculation. We found that both factors have a high impact on the outcomes. However, the rate of vaccine administration has a higher impact in reducing the burden of the COVID-19 pandemic. This result shows that health institutions need to focus in increasing the vaccine inoculation pace and create awareness in the population about the importance of COVID-19 vaccines.

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Beta- and Novel Delta-Coronaviruses Are Identified from Wild Animals in the Qinghai-Tibetan Plateau, China

Cited by 25 publications

References 38 publications

Alterations in Phenotypes and Responses of T Cells Within 6 Months of Recovery from COVID-19: A Cohort Study

Alterations in Phenotypes and Responses of T Cells Within 6 Months of Recovery from COVID-19: A Cohort Study

Impact of a New SARS-CoV-2 Variant on the Population: A Mathematical Modeling Approach

Analysis of key factors of a SARS-CoV-2 vaccination program: A mathematical modeling approach

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