Beta-Blockers and Hypertension: Some Questions and Answers

Fıcı, Francesco; Robles, Nicolás Roberto; Tengiz, İstemihan

doi:10.1007/s40292-023-00576-3

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…Secondly, hypertension and low HDL cholesterol levels may trigger in ammation responses (37)(38)(39), which can also cause damage to vestibular tissues and affect vestibular function (40,41). Lastly, it is possible that hypertension and low HDL cholesterol levels affect neurotransmitter secretion and function (42), thereby in uencing vestibular function (43). Further research is needed to explore the potential mechanisms underlying the association between low HDL cholesterol levels, high blood pressure, and vestibular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Exploring the relationship between Metabolic Syndrome and Vestibular Dysfunction: insights from NHANES data and mendelian randomization analysis

Zhang

2024

Preprint

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Introduction The relationship between metabolic syndrome and vestibular dysfunction has attracted significant attention; however, consensus regarding their association remains elusive. This study aims to comprehensively evaluate the relationship between metabolic syndrome and vestibular dysfunction through observational analysis of the NHANES database and Mendelian Randomization (MR) analysis. Methods Data from the NHANES database spanning 1999 to 2004 were utilized for observational analysis, alongside Mendelian Randomization (MR) methodology. NHANES data analysis was conducted using EmpowerStats 4.1, while MR analysis utilized publicly available Genome-Wide Association Studies (GWAS) data. Results Observational analysis of NHANES data revealed an association between metabolic syndrome and vestibular dysfunction in unadjusted models, which disappeared upon adjustment for various confounding factors. MR analysis results indicated no significant causal relationship between metabolic syndrome and vestibular dysfunction; however, low high-density lipoprotein cholesterol levels and hypertension were identified as potential risk factors for vestibular dysfunction. Conclusion The findings of this study suggest that there is no apparent association between metabolic syndrome and vestibular dysfunction. However, low high-density lipoprotein cholesterol levels and hypertension may serve as risk factors for vestibular dysfunction. This discovery contributes to the precision prevention and treatment of vestibular dysfunction, thereby enhancing the quality of life for affected individuals.

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Section: Discussionmentioning

confidence: 99%

Exploring the relationship between Metabolic Syndrome and Vestibular Dysfunction: insights from NHANES data and mendelian randomization analysis

Zhang

2024

Preprint

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“…Concerning the effect of β-block β-blockers are frequently used in HTN treatment. When treating HTN the different pathophysiology of HTN in the young (predominant SNS hyperactivity) and elderly patients (increased large artery stiffness, high aortic systolic pressure) should be considered with the use of non-vasodilating β-blockers (e.g., bisoprolol), preferred, as first-line, in young/middle aged hypertensive subjects and vasodilating β-blockers (e.g., carvedilol or nebivolol) in elderly hypertensives [83]. The downgrading of β-blockers by the European HTN guideline is not justified [84].…”

Section: Medical Neuromodulationmentioning

confidence: 99%

The Sympathetic Nervous System in Hypertensive Heart Failure with Preserved LVEF

Triposkiadis,

Briasoulis,

Sarafidis

et al. 2023

JCM

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The neurohormonal model of heart failure (HF) pathogenesis states that a reduction in cardiac output caused by cardiac injury results in sympathetic nervous system (SNS) activation, that is adaptive in the short-term and maladaptive in the long-term. This model has proved extremely valid and has been applied in HF with a reduced left ventricular (LV) ejection fraction (LVEF). In contrast, it has been undermined in HF with preserved LVEF (HFpEF), which is due to hypertension (HTN) in the vast majority of the cases. Erroneously, HTN, which is the leading cause of cardiovascular disease and premature death worldwide and is present in more than 90% of HF patients, is tightly linked with SNS overactivity. In this paper we provide a contemporary overview of the contribution of SNS overactivity to the development and progression of hypertensive HF (HHF) as well as the clinical implications resulting from therapeutic interventions modifying SNS activity. Throughout the manuscript the terms HHF with preserved LVEF and HfpEF will be used interchangeably, considering that the findings in most HFpEF studies are driven by HTN.

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A Genetic Dissection of Vascular Risk Factors for Cervical Artery Dissection

De Backer

2023

Journal of the American College of Cardiology

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Beta-Blockers and Hypertension: Some Questions and Answers

Cited by 4 publications

References 49 publications

Exploring the relationship between Metabolic Syndrome and Vestibular Dysfunction: insights from NHANES data and mendelian randomization analysis

Exploring the relationship between Metabolic Syndrome and Vestibular Dysfunction: insights from NHANES data and mendelian randomization analysis

The Sympathetic Nervous System in Hypertensive Heart Failure with Preserved LVEF

A Genetic Dissection of Vascular Risk Factors for Cervical Artery Dissection

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