Beta-carotene-bound albumin nanoparticles modified with chlorin e6 for breast tumor ablation based on photodynamic therapy

Pham, Thi Thu Phuong; Lee, Sungin; Lee, Changkyu; Seo, Bohyung; Park, Sang‐Hyun; Oh, Kyung Taek; Lee, Eun Seong; Choi, Han‐Gon; Shin, Beom Soo; Youn, Yu Seok

doi:10.1016/j.colsurfb.2018.07.016

Cited by 40 publications

(37 citation statements)

References 51 publications

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“…The authors concluded then that this composite associated with a combinatorial dynamic therapy proved to be a highly efficient pathway to target and eliminate cancer cells both in vitro and in vivo. Other strategies to further enhance the delivery of PDT drugs into breast tumors involved systems based on liposomes or the use of albumin nanoparticles [ 147 , 148 ].…”

Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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Due to their physical and chemical characteristics, anthocyanins are amongst the most versatile groups of natural compounds. Such unique signature makes these compounds a focus in several different areas of research. Anthocyanins have well been reported as bioactive compounds in a myriad of health disorders such as cardiovascular diseases, cancer, and obesity, among others, due to their anti-inflammatory, antioxidant, anti-diabetic, anti-bacterial, and anti-proliferative capacities. Such a vast number of action mechanisms may be also due to the number of structurally different anthocyanins plus their related derivatives. In this review, we highlight the recent advances on the potential use of anthocyanins in biological systems with particular focus on their photoprotective properties. Topics such as skin aging and eye degenerative diseases, highly influenced by light, and the action of anthocyanins against such damages will be discussed. Photodynamic Therapy and the potential role of anthocyanins as novel photosensitizers will be also a central theme of this review.

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Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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“…BSA-Cur-NPs and ICG-BSA-Cur-NPs were prepared using nanoparticle albumin-bound (nab TM ) technology with some adjustments. 39 Briefly, aliquots of 50 mg BSA/1.5 mg ICG or 50 mg BSA were dissolved in 5 mL deionized water (DW). Aliquots (2 mg) of Cur was dissolved in 200 μL of a 9:1 solution of chloroform and ethanol.…”

Section: Preparation Of Bsa-cur-nps and Icg-bsa-cur-npsmentioning

confidence: 99%

“…First, the MTT colorimetric assay was conducted using a slight modification of previous methods. 13,20,39 Briefly, N2a cells were seeded in 96-well plates at a density of 1 × 10 4 cells/well. Following 24 h of incubation, the cells were treated with various concentrations of free ICG, ICG-BSA-Cur-NPs, and BSA-Cur-NPs.…”

Section: Cytotoxicity Of Icg-bsa-cur-npsmentioning

confidence: 99%

“…The protocol was partly based on one reported previously. 21,38,39 Briefly, 5 × 10 4 cells were seeded onto glass slides in 12-well plates. The cells were treated in the same manner as for the live/dead assay.…”

Section: Cytotoxicity Of Icg-bsa-cur-npsmentioning

confidence: 99%

“…27,35 Previously, we developed a variety of nab TM -based antitumor formulations for treating many cancers. 20,21,[37][38][39] However, the antitumor efficacies of those formulations relied on only chemotherapeutic effects. Herein, we sought to prepare albumin nanoparticles with antitumor efficacies by dual advantages of hyperthermia and a chemotherapeutic agent.…”

Section: Introductionmentioning

confidence: 99%

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<p>Indocyanine Green and Curcumin Co-Loaded Nano-Fireball-Like Albumin Nanoparticles Based on Near-Infrared-Induced Hyperthermia for Tumor Ablation</p>

Pham¹,

Le²,

Kim³

et al. 2020

IJN

Self Cite

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Background: Indocyanine green (ICG) has received considerable interest as a biocompatible organic photothermal agent, and curcumin (Cur) is considered an attractive natural chemopreventive and chemotherapeutic compound. However, the in vivo applicability of ICG and Cur is significantly restricted by their poor ability to target tumors and their extremely low solubility. Materials and Methods: To address these problems, ICG/Cur-loaded albumin nanoparticles (ICG-BSA-Cur-NPs) based on the nab TM (nanoparticle albumin-bound) technology were applied to neuroblastomas in vivo. Results: The fabricated ICG-BSA-Cur-NPs were found to be spherical, ~150 nm in size and highly dispersible and stable in aqueous solution. Approximately 80% of the incorporated ICG and Cur were gradually released from the NPs over 48 h. All formulations of ICG-BSA-Cur-NPs (5~20 µg/mL) showed efficient hyperthermia profiles (up to 50-60°C within 5 min) in response to 808-nm NIR laser irradiation in vitro and in vivo. Notably, ICG-BSA-Cur-NPs illuminated with 808-nm laser irradiation (1.5 W/cm 2) showed excellent cytotoxicity toward N2a cells in vitro and undisputable antitumor efficacy in N2a-xenografted mice in vivo, compared to other tested sample groups (tumor volumes for PBS, BSA-Cur-NPs, free ICG, and ICG-BSA-Cur-NPs groups were 1408.6 ± 551.9, 1190.6 ± 343.6, 888.6 ± 566.2, and 103.0 ± 111.3 mm 3 , respectively). Conclusion: We demonstrate that these hyperthermal chemotherapeutic ICG-BSA-Cur-NPs have potential as a future brain tumor treatment.

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Bioactive Compounds

Visentini¹,

Pérez²,

Ferrado³

et al. 2022

Biomolecules From Natural Sources

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Beta-carotene-bound albumin nanoparticles modified with chlorin e6 for breast tumor ablation based on photodynamic therapy

Cited by 40 publications

References 51 publications

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

<p>Indocyanine Green and Curcumin Co-Loaded Nano-Fireball-Like Albumin Nanoparticles Based on Near-Infrared-Induced Hyperthermia for Tumor Ablation</p>

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