Beta globin haplotypes in hemoglobin S carriers in Colombia

Clinical and demographic characteristics of sickle cell disease in colombian children

“…Additionally, Colombian patients with sickle cell disease could have a more severe expression of the disease because Benin and Bantu haplotypes appear more frequently [11].…”

“…Despite knowing the population impact of the disease and the prevalence of up to 10% of Hb S in the Colombian child population [11], no studies describe the characteristics of the pediatric population.…”

“…All of the patients belong to the Colombian Pacific Region, which has a high concentration of Afro-descendant population. In the study by Durán et al [11], a cord sample of 1,200 Colombian children was obtained, from which 33 (2.75%) had hematological alterations associated with Hb S and the Bantu haplotype, suggesting that most of the affected patients migrated from Africa. It possibly explains the high proportion of patients with sickle cell disease in this country's regions.…”

Sickle Cell Trait Induces Oxidative Damage on Plasmodium falciparum Proteome at Erythrocyte Stages

“…For this, donors with 36.4–43.0% of HbAS were identified by horizontal hemoglobin electrophoresis. A 6% prevalence was calculated in our random sample, establishing in the range of 5–10% reported for some regions of the Colombian territory [20,21]. Next, parasites were cultured and processed to obtain proteomes at ring, trophozoites and schizonts stages.…”