Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats

Abstract

Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 µg/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p ≤ 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity.

Preventive effects of yogurt fortified with purple roselle extract against cardiotoxicity in rats exposed with 2,3,7,8-tetrachlorodibenzo-p-dioxin

“…Continuous administration of TCDD can induce damage to the heart tissue. The many foci of myocardial degeneration found in the rat heart were characteristic of the look of cardiomyopathy [2,5,18]. Apoptosis was indicated by the presence of pyknotic myonuclei…”

“…Dioxins congener that have the highest toxicity is 2,3,7,8 -Tetrachlorodibenzo-p-dioxin (TCDD). In humans and laboratory animals, TCDD induced carcinogenesis, teratogenicity, reproductive toxicity, hepatotoxicity, endocrine disruption, wasting syndrome, and immunological dysfunction [2,3].…”

“…Cardiotoxicity manifestations due to dioxins exposure include ischemic heart disease and an increase in blood pressure. In addition, cardiac tissue damage caused by dioxin intoxication includes hemorrhage and necrosis [2,4]. Some in vivo investigations suggest that TCDD exposure has serious consequences for the cardiovascular system [5].…”

“…Furthermore, TCDD accelerates the production of reactive oxygen species (ROS), which causes lipid peroxidation, cell membrane damage, DNA and protein damage at the cellular level. TCDD was found to cause oxidative stress in various organs [2]. Studies suggested that using antioxidant supplementation possible to counteract the adverse effect of TCDD toxicity.…”

Gastroprotective Activity of Olive Leaves Extract on 2,3,7,8 Tetrachlorodibenzo-p-dioxin Induced Gastric Fundic Mucosal Injury in Adult Male Albino Rats (Light and Electron Microscopic Study)

“…The health threat due to extensive exposure to dioxins in humans has been stated by some researchers [4] . Cadiotoxicity, nerve illness, tumorigenesis effect, reproductive dysfunction and immune system defect have been recorded as adverse effects to human and animal bodies due to polychlorinated biphenyls and dioxins [5] .…”