Betamethasone 17-Valerate: A New Topical Corticosteroid

Williams, D.I.; Wilkinson, D. S.; Overton, James; Milne, JohnA.; Mckenna, WilliamB.; Lyell, Alan; Church, R.E.

doi:10.1016/s0140-6736(64)91205-x

Cited by 46 publications

(16 citation statements)

References 9 publications

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“…Most of the patients we have described have been using betamethasone 17-valerate. This was a matter of local preference stemming, no doubt, from the involvement of one of us in the initial trial of this agent (Williams et al, 1964). Several other corticosteroids were also used.…”

Section: Commentsmentioning

confidence: 99%

Perioral dermatitis: a 12-year review

Wilkinson

Kirton

Wilkinson

2006

British Journal of Dermatology

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100

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SUMMARY A continuing study of perioral dermatitis over a period of 12 years is presented. A distinction is made between various patterns of circumoral and paranasal dermatitis and the clinical picture that we describe as ‘perioral dermatitis’. No cases were seen before 1966 but the number of patients presenting to hospital clinics or in private practice rose dramatically until 1970–1972, after which there has been a progressive fall in numbers. In this period, 259 patients were diagnosed as having the condition and of these 203, resident in an area of some 275,000 population and seen by one or other of us on at least two occasions, form the basis of this study. There were 173 females, fifteen males and fifteen children under 12 years of age. In many cases it was possible to suggest the primary lesion for which patients sought treatment. In sixty‐nine patients this consisted of a para‐oral eruption on the side of the chin and, in forty‐one a paranasal erythematous dermatitis. The characteristic appearance and spread of the eruption to the glabella and eyelids are described. A few patients, mostly male, showed lesions around the eyelids only, from treatment of seborrhoeic dermatitis. All but nine of the patients acknowledged the use of potent (not necessarily fluorinated) topical corticosteroids over long periods; in many cases these were self‐administered. Some of the children had been treated with preparations intended for their mothers. The numerous aetiological agents that have been incriminated as causes of this eruption are examined. We believe that the prolonged use of topical potent corticosteroids is the only one tenable from our observations. The role of hormonal factors and of local irritant agents is examined in this context. Tetracyclines are curative in the great majority of patients in 6 weeks if local corticosteroids are discarded. Relapses are rare. Perioral dermatitis is a most satisfying condition to treat but several questions remain unanswered. The current ‘revolt’ against all forms of cortisone may enable us to answer some of these in the near future.

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Section: Commentsmentioning

confidence: 99%

Perioral dermatitis: a 12-year review

Wilkinson

Kirton

Wilkinson

2006

British Journal of Dermatology

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100

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“…Group 2. Fluocinolone acetonide 0-025% which, after 8 years of clinical use, appears to be equally effective as betamethasone 17-valerate 0-1%, although the initial report of Williams et al (1964) found betamethasone 17-valerate to be superior. Group 3.…”

Section: Steroid Preparationsmentioning

confidence: 99%

A comparison of the effect of various topically active steroids on the clinical and histological features of psoriasis

1973

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SUMMARY The effect of betamethasone 17‐valerate, fluclorolone acetonide, fluocinolone acetonide and formocortal on the clinical and histological features and mitotic counts of psoriatic epidermis have been compared. In five of the six patients studied the preparations were used under polythene occlusive dressings. Biopsies were carried out before treatment and then at varying intervals for a week. All the four steroid preparations appeared effectively to reverse the psoriatic lesion. Betamethasone 17‐valerate and fluocinolone acetonide were found to give similar and slightly superior results to fluclorolone acetonide and formocortal on the criteria used in this study. It would appear that at the present time more potent topical steroids would not be of any advantage in the treatment of psoriasis. Drugs with a more selective action on the psoriatic process and without the steroid effect on collagen are required.

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“…All were outpatients with bilateral, approximately symmetrical disease, between the lesions of which there was judged to be no difference in severity. The study was double-bhnd, with the ointments randomly allocated to the right-and left-sided lesion, the protocol being similar to that described by Williams et al (1964). Occlusive dressings were not used.…”

Section: Clinical Activitymentioning

confidence: 99%