Betamethasone valerate foam 0.12%: a novel vehicle with enhanced delivery and efficacy

Franz, Thomas; Parsell, Dawn A.; Halualani, Roger M.; Hannigan, John F.; Kalbach, Jacqueline P.; Ma, Yutao; Harkonen, W. Scott

doi:10.1046/j.1365-4362.1999.00782.x

Cited by 105 publications

(75 citation statements)

References 8 publications

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“…At the end of 28-days of treatment, patients on betamethasone valerate foam showed significantly better clearing of plaques than those on betamethasone valerate lotion and placebo. Further, there was no evidence of increased toxicity for betamethasone valerate foam (Franz et al, 1999).…”

Section: Betamethasonementioning

confidence: 90%

“…Betamethasone valerate foam formulated in a thermolabile hydroethanolic foam vehicle is absorbed more rapidly, and demonstrated 2-fold greater skin penetration in a human cadaver skin model, than the betamethasone valerate lotion (Franz et al, 1999). Safety and efficacy of the betamethasone valerate foam was evaluated in a randomized, multicenter, double-blind, active-and placebo-controlled trial in adult patients with moderate to severe scalp psoriasis (Franz et al, 1999).…”

Section: Betamethasonementioning

confidence: 99%

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Topical Therapies for Psoriasis

Mitra¹,

Atillasoy²

2012

Psoriasis

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Section: Betamethasonementioning

confidence: 90%

Section: Betamethasonementioning

confidence: 99%

Topical Therapies for Psoriasis

Mitra¹,

Atillasoy²

2012

Psoriasis

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“…The potent topical steroids are corticosteroids, clobetasol propionate or betamethasone propionate applied once or twice daily. In prolonged use of topical steroids which cause skin atrophy, hair growth, hypopigmentation 53 . Different newer formulations are available to enhance the delivery of topical corticosteroids.…”

Section: Steroidsmentioning

confidence: 99%

Current Trends in Treatment and Management of Psoriasis: An Updated Review

Cherukuri¹,

Vuppalapati²,

Narayanan³

et al. 2018

Int. Res. J. Pharm.

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Psoriasis is a proliferative autoimmune skin disease which is affecting 2% of worldwide population. It is characterized by itching, skin rashes and red scalps with white scales on the skin. Though, different types are reported, common existing form of psoriasis is plaque psoriasis. The epidemiology of disease seems to be remains unknown, but the incidence varies, surrounded by the different countries. The pathophysiology of the disease appears as drastic cellular changes occur both in epidermis and dermis which narrates to keratinocyte hyperproliferation. Earlier available medications like emollients and some keratolyitic agents has not proven promising role in controlling the disease burden. But, in advance regimen, with wide range of therapeutic mediators like coal tar, anthranilin, calcineurin inhibitors, methotrexate, retinoids, cyclosporine are proven to be effective in treating mild psoriasis to severe psoriasis. In recent years, phototherapy has once again emerged as most recommended due to ease of treatment and its intoxications. Hence, this review emphasizes the therapeutic agents available in market and its effectiveness in controlling the psoriasis.

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“…These foam formulations are associated with better patient compliance and improvements in quality of life [88,89]. Table 4 summarizes the new drug carrier formulations of TC.…”

Section: Formulations Of Tcmentioning

confidence: 99%