Betanin inhibits the myeloperoxidase/nitrite-induced oxidation of human low-density lipoproteins

Allegra, Mario; Tesoriere, Luisa; Livrea, M. A.

doi:10.1080/10715760601038783

Cited by 62 publications

(48 citation statements)

References 46 publications

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“…There are also not reports of any effect of betalains in the insulin or glucose tolerance. As with other betalains 3,[6][7][8][9] , the main biological action of betanidin known to date in animal biomolecules is its antioxidant capacity 10 . Betalains have also been shown to induce the expression of quinone reductases 11 , to inhibit the expression of ICAM-1 12 and to decrease the DNA methyl transferase activity 13 .…”

Section: Resultsmentioning

confidence: 99%

Betanidin significantly reduces blood glucose levels in BALB/c mice fed with an atherogenic diet

Lugo-Radillo

Delgado‐Enciso

Peña-Beltran

2012

Nat. Prod. Bioprospect.

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Abstract:Six weeks BALB/c mice were fed with an atherogenic diet for 24 weeks and purified water ad libitum. An experimental group was given betanidin, orally, during the last 40 days of the experiment at a dose of 9.6 mg per mouse per day. Negative controls were fed with standard rodent chow only. Glycemia was measured at the end of the experiment, after overnight fasting. The group treated with betanidin presented a highly significant reduction of 50.94% compared to positive controls. We conclude that betanidin reduces glycemia in BALB/c mice by an unidentified mechanism.

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Section: Resultsmentioning

confidence: 99%

Betanidin significantly reduces blood glucose levels in BALB/c mice fed with an atherogenic diet

Lugo-Radillo

Delgado‐Enciso

Peña-Beltran

2012

Nat. Prod. Bioprospect.

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“…As for the other model, betanin effectively inhibited the production of lipid hydroperoxides in human LDL submitted to a MPO/nitrite-induced oxidation (Allegra et al 2007). In this system, the time-course of lipid oxidation follows the same phases as the copper-oxidised LDL, followed by the formation of lipid hydroperoxides.…”

Section: Inhibition Of Low-density Lipoprotein Oxidation By Betaninmentioning

confidence: 78%

“…It was imperative from a number of kinetic measurements that the betalain can block the process at various levels, that betanin not only acts as a scavenger of the initiator radical nitrogen dioxide, but can also act as a lipoperoxyl radical scavenger. In addition, unidentified products from the oxidation of betanin by MPO/nitrite further inhibit LDL oxidation as effectively as the parent compound (Allegra et al 2007), thus extending the antioxidative protection of LDL beyond the time in which betanin is consumed. It should be mentioned that other studies showed that betanin is a reducing substrate for the intermediates-compound I/II of the peroxidative MPO cycle , an action potentially pro-oxidant in this LDL model.…”

Section: Inhibition Of Low-density Lipoprotein Oxidation By Betaninmentioning

confidence: 99%

“…Both these models have been used to assess whether the sensitivity of human LDL to oxidation could be altered by betanin (Tesoriere et al 2003;Allegra et al 2007). …”

Section: Inhibition Of Low-density Lipoprotein Oxidation By Betaninmentioning

confidence: 99%

“…To this purpose chemical lipid systems such as methanolic solutions of methyl linoleate and soybean phosphatidylcholine liposomes have been used. In other studies, the antioxidant activity of betanin has been evaluated in more complex biological lipid matrixes such as LDL (Tesoriere et al 2003;Allegra et al 2007). …”

Section: Introductionmentioning

confidence: 99%

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Lipoperoxyl Radical Scavenging and Antioxidative Effects of Red Beet Pigments

Livrea

Tesoriere

2012

Red Beet Biotechnology

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Aerobic life is characterized by a steady formation of reactive oxygen species and free radicals, which is almost entirely counteracted by endogenous primary and secondary antioxidant systems. Maintenance of these systems is then imperative to ensure a continuous defense to cells and to avoid conditions known as oxidative stress. Apart from antioxidant vitamins, many compounds from the plant kingdom are now considered very helpful to maintain a proper cell redox balance. Among them, betalain pigments have received recent attention. Betanin (betanidin-5-O-β glucoside) is the main betacyanin from red beet. Redox potential, ability to interact with lipid structures and bioavailability in humans make this molecule a potential natural antioxidant with protective effects in vivo. This review summarizes the peroxyl radicalscavenging activity of the molecule and of its aglycone betanidin, as observed in a few chemical or biological models. Abstract Aerobic life is characterized by a steady formation of reactive oxygen species and free radicals, which is almost entirely counteracted by endogenous primary and secondary antioxidant systems. Maintenance of these systems is then imperative to ensure a continuous defense to cells and to avoid conditions known as oxidative stress. Apart from antioxidant vitamins, many compounds from the plant kingdom are now considered very helpful to maintain a proper cell redox balance. Among them, betalain pigments have received recent attention. Betanin (betanidin-5-O-b glucoside) is the main betacyanin from red beet. Redox potential, ability to interact with lipid structures and bioavailability in humans make this molecule a potential natural antioxidant with protective effects in vivo. This review summarizes the peroxyl radical-scavenging activity of the molecule and of its aglycone betanidin, as observed in a few chemical or biological models.

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Pigment Biosynthesis II: Betacyanins and Carotenoids

Sakuta

Ohmiya

2011

Plant Metabolism and Biotechnology

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Betanin inhibits the myeloperoxidase/nitrite-induced oxidation of human low-density lipoproteins

Cited by 62 publications

References 46 publications

Betanidin significantly reduces blood glucose levels in BALB/c mice fed with an atherogenic diet

Betanidin significantly reduces blood glucose levels in BALB/c mice fed with an atherogenic diet

Lipoperoxyl Radical Scavenging and Antioxidative Effects of Red Beet Pigments

Pigment Biosynthesis II: Betacyanins and Carotenoids

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