Betel nut chewing associated with increased risk of arterial stiffness

Wei, Yu-Ting; Chou, Yu Tsung; Yang, Yi Ching; Chou, Chieh Ying; Lu, Feng Hwa; Chang, Chih Jen; Wu, Jin Shang

doi:10.1016/j.drugalcdep.2017.07.035

Cited by 19 publications

(18 citation statements)

References 69 publications

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“…37,38 Others found that chewing betel nut more frequently would increase the higher blood pressure and the behavior of chewing betel nut was also associated with an increased risk of arterial stiffness. 39,40 Therefore, it is probable to suggest that behavior of chewing betel nut could effect on small vessel disease and then it would cause the increasing of DR risk; and its relation with biological mechanism is worthy of further discussion.…”

Section: Discussionmentioning

confidence: 99%

The related risk factors of diabetic retinopathy in elderly patients with Type 2 diabetes mellitus: A cohort study

Chiu

Tsai

et al. 2020

Preprint

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KEYWORDS health behavior; chewing betel nut; dilated fundus examination 2 Abstract Background: Diabetic retinopathy (DR) caused by small vessel disease was the main cause of blindness in person with diabetes, and it mainly occurred in patients with Type 2 diabetes mellitus (T2DM). Taiwan was one of the Asian countries with the highest prevalence rate of DR, there were only few studies for the risk of DR in patients with T2DM in Taiwan. According to some studies have shown DR was a major cause of blindness on elderly both in developed and other developing countries. The purpose was to investigate the related risk factors of DR in elderly patients with T2DM. Methods: During July 2010 to December 2017, 4010 T2DM patients without DR were preselected for this study, but 792 patients completed the continuously follow-up evaluation. Patients were invited to have an outpatient visit at least every three months, and they were asked to fill out a brief questionnaire and collect their blood samples. Additionally, statistical methods used independent sample T-test, Chi-square tests and logistic regression in univariate analysis to analyze the relationships between onset DR and each related factor; and finally the optimal multivariate logistic regression model would be determined by stepwise model selection. Results: Of the 792 effective samples, 611 patients (77.1%) progressed to DR and 181 patients

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Section: Discussionmentioning

confidence: 99%

The related risk factors of diabetic retinopathy in elderly patients with Type 2 diabetes mellitus: A cohort study

Chiu

Tsai

et al. 2020

Preprint

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“…Betel nut chewers were categorized into non-chewers, ex-chewers, and current chewers. Participants who chewed betel nut at least once weekly in the previous 6 months were defined as current chewers [5]. Ex-chewers were defined participants who previously chewed betel nut at least once per week for no less than 6 months but ceased for at least the last six months.…”

Section: Methodsmentioning

confidence: 99%

“…It is estimated that about 600 million people use betel nut worldwide to engage in social customs, religious practices, and cultural rituals, or as a psychoactive substance [1,3]. In Taiwan, betel nuts are often chewed with leaves, flowers, or stems of Piper betle, or chewed with additives such as tobacco, cardamom, catechu, slaked lime, or cloves [4,5]. Betel nut chewing is associated with a risk of oral cancer due to the carcinogenic effect of arecoline, polyphenols, and tannins within betel nuts, as well as due to safroles in Piper betle leaves, flowers, and stems [6].…”

Section: Introductionmentioning

confidence: 99%

A Positive Relationship between Betel Nut Chewing and Significant Liver Fibrosis in NAFLD Subjects, but Not in Non-NAFLD Ones

Chou

Sun

et al. 2021

Nutrients

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Background: Betel nut chewing is associated with oral cancer, cardiovascular disease, liver cirrhosis, and hepatocellular carcinoma (HCC). The aim of this study was to explore the association of betel nut chewing with liver fibrosis in subjects with and without nonalcoholic fatty liver disease (NAFLD). Method: A total of 5967 subjects were enrolled. NAFLD was diagnosed with ultrasonography. Betel nut chewing was classified into non-chewing, ex-chewing, and current chewing, and cumulative dosages were calculated. The aspartate aminotransferase (AST)/platelet ratio index and NAFLD fibrosis scores (NFS) were calculated for evaluation of liver fibrosis. Results: NAFLD increased the associated risk of liver fibrosis in those with (odds ratio (OR): 5.51, 95% confidence interval (CI): 3.09–9.80) and without betel nut chewing (OR: 2.33, 95% CI: 1.64–3.29). In subjects without NAFLD, betel nut chewing was not associated with liver fibrosis (OR: 1.12, 95% CI: 0.44–2.86). In subjects with NAFLD, cumulative betel nut chewing and ex- and current chewing were positively associated with NFS and significant liver fibrosis. Conclusions: In subjects with NAFLD, betel nut chewing, even ex-chewing, was associated with a higher risk of liver fibrosis, where higher cumulative levels were found to increase the risk of significant liver fibrosis. However, the associated risk of liver fibrosis due to betel nut chewing was insignificant in subjects without NAFLD.

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“…Moreover, areca nut chewing in an earlier age of onset, results in a poorer response to chemotherapy and a lower survival rate of the malignancy (Chen et al., 2017). In addition, the gastrointestinal system (Chuang et al., 2017), the male reproductive system (Huang & Jiann, 2017), the cardiovascular system (Wei et al., 2017) and the metabolic system (Tseng, 2010) are susceptible to negative impacts resulting from areca nut consumption. The cost to sustain habitual use of areca nut and the economic burden of health conditions resulting from this habit are becoming a significant issue for public health and health economics in some countries (Pratt, 2014; World Health Organization.…”

Section: Introductionmentioning

confidence: 99%

Social and behavioural determinants of areca nut consumption in adolescents

Huang

Zachar

2020

Oral Diseases

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Areca nut is used as a masticatory substance by approximately 600 million people worldwide and is strongly interwoven in local arts and craft, social customs, religious practices and cultural rituals (Gupta & Warnakulasuriya, 2002). The chewing habit is endemic throughout the Indian subcontinent and large parts of South East Asia (Gupta & Warnakulasuriya, 2002). It is obtained from the tropical palm tree known as Areca catechu and has been found to be the fourth most commonly used drug, trailing behind tobacco, alcohol and caffeine (Winstock, 2002). The extract of areca nut has also shown anti-depressant effects (Abbas et al., 2013) with a potential to enhance impulsive habitual use (

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Betel nut chewing associated with increased risk of arterial stiffness

Cited by 19 publications

References 69 publications

The related risk factors of diabetic retinopathy in elderly patients with Type 2 diabetes mellitus: A cohort study

The related risk factors of diabetic retinopathy in elderly patients with Type 2 diabetes mellitus: A cohort study

A Positive Relationship between Betel Nut Chewing and Significant Liver Fibrosis in NAFLD Subjects, but Not in Non-NAFLD Ones

Social and behavioural determinants of areca nut consumption in adolescents

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