Better therapeutic effect of oral administration of GS441524 compared with GC376

Yan, Yuanyuan; Jia, Lee; Jiao, Zhe; Yang, Mengfang; Li, Lisha; Wang, Gang; Chen, Yixi; Li, Mengxia; Zhou, Shuhua; Shi, Yuejun; Peng, Guiqing

doi:10.1016/j.vetmic.2023.109781

Veterinary Microbiology

2023

DOI: 10.1016/j.vetmic.2023.109781

|View full text |Cite

Better therapeutic effect of oral administration of GS441524 compared with GC376

Yuanyuan Yan

Lee Jia

Zhe Jiao

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Applications of some artificial intelligence tools in the drug design of some compounds targeting the main viral protease of the Feline Infectious Peritonitis Virus (FIPV) in cats

Khan,

Shah,

Duraisamy

et al. 2024

Preprint

View full text Add to dashboard Cite

Feline infectious peritonitis virus (FIPV) is one of cats’ most serious viral infections. The FIPV infection induces a complicated syndrome in the affected cats, including immunosuppression and severe inflammatory conditions. Unfortunately, these vaccines cannot prevent cats from getting infected with these viral infections. There is ongoing research on preparing antiviral therapies against FIPV in cats. However, these are still in clinical trials and have not been fully approved by the drug authorities in many countries, including the USA. Targeting the main viral proteases is one of the promising trends in the drug design of many viral diseases, including coronaviruses. The main goal of the current study was to repurpose and test the efficacy of some known antiviral drugs to treat FIPV infection in cats by targeting the FIPV-main protease enzyme. To achieve these goals, we used the in-silico prediction and molecular docking tools to screen and identify some drugs targeting FIPV-MPro. We used the docking and binding energies as the main parameters for selecting target compounds (FIPV-MPro). Our results show that out of the 15 antiviral and immunomodulatory compounds, the top-ranked inhibitors for the FIPV-Mpro are (Michael acceptor inhibitors (N3), Sofosbuvir, and methotrexate).In conclusion, our results confirmed the potential applications of the predicted FIPV-Mpro inhibitors either independently or in combination with other immune-modulatory compounds. Further in vitro and in vivo studies are encouraged to test the efficacy of these identified compounds as potent inhibitors for the MPro of the FIPV in cats. This study will pave the way for the development of novel drugs that treat FIPV infection in cats.

show abstract

Applications of some artificial intelligence tools in the drug design of some compounds targeting the main viral protease of the Feline Infectious Peritonitis Virus (FIPV) in cats

Khan,

Shah,

Duraisamy

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Better therapeutic effect of oral administration of GS441524 compared with GC376

Cited by 1 publication

References 25 publications

Applications of some artificial intelligence tools in the drug design of some compounds targeting the main viral protease of the Feline Infectious Peritonitis Virus (FIPV) in cats

Applications of some artificial intelligence tools in the drug design of some compounds targeting the main viral protease of the Feline Infectious Peritonitis Virus (FIPV) in cats

Contact Info

Product

Resources

About