Betulin and Crinum asiaticum L. bulbs extract attenuate pulmonary fibrosis by down regulating pro-fibrotic and pro-inflammatory cytokines in bleomycin-induced fibrosis mice model

Ofori, Michael; Danquah, Cynthia Amaning; Asante, Joshua; Ativui, Selase; Doe, Peace; Abdul-Nasir Taribabu, Alhassan; Nugbemado, Isaac Newton; Mensah, Adwoa Nkrumah

doi:10.1016/j.heliyon.2023.e16914

Cited by 4 publications

(2 citation statements)

References 82 publications

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“…Schweickerdt Herbarium of the University of Pretoria, and the herbarium of the Faculty of Pharmacy and Pharmaceutical Sciences, KNUST, Kumasi, Ghana (Supplementary File Table S1 ). Collected plants were identified by the following, Mr. J. Simpson, University of Pretoria 66 , Dr. Henry Sam 69 and Mr. Clifford Asare 25 , 68 , Department of Herbal Medicine, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Ghana, and Mr D Schuhardt, Mr E Nienaber, Mr Hans Vahrmeijer, Mr J Male, Mr FJ Potgieter, DJE Venter, Mr E Nienaber and JD Spies (all employed by Council for Scientific and Industrial Research at the time of collections and identifications done at South African Biodiversity Institute) and Mr JJ Meyer of the South African Biodiversity Institute. All experiments were carried out in accordance with relevant guidelines and regulations.…”

Section: Methodsmentioning

confidence: 99%

Section: Plant Collectionmentioning

confidence: 99%

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Investigation of the antimycobacterial activity of African medicinal plants combined with chemometric analysis to identify potential leads

Moyo,

Ofori,

Bodede

et al. 2024

Sci Rep

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The emergence of drug-resistant Mycobacterium tuberculosis strains is a threat to global health necessitating the discovery of novel chemotherapeutic agents. Natural products drug discovery, which previously led to the discovery of rifamycins, is a valuable approach in this endeavor. Against this backdrop, we set out to investigate the in vitro antimycobacterial properties of medicinal plants from Ghana and South Africa, evaluating 36 extracts and their 252 corresponding solid phase extraction (SPE) generated fractions primarily against the non-pathogenic Mycobacterium smegmatis and Mycobacterium aurum species. The most potent fraction was further evaluated in vitro against infectious M. tuberculosis strain. Crinum asiaticum (bulb) (Amaryllidaceae) emerged as the most potent plant species with specific fractions showing exceptional, near equipotent activity against the non-pathogenic Mycobacterium species (0.39 µg/ml ≤ MIC ≤ 25 µg/ml) with one fraction being moderately active (MIC = 32.6 µg/ml) against M. tuberculosis. Metabolomic analysis led to the identification of eight compounds predicted to be active against M. smegmatis and M. aurum. In conclusion, from our comprehensive study, we generated data which provided an insight into the antimycobacterial properties of Ghanaian and South African plants. Future work will be focused on the isolation and evaluation of the compounds predicted to be active.

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Section: Methodsmentioning

confidence: 99%

Section: Plant Collectionmentioning

confidence: 99%

Investigation of the antimycobacterial activity of African medicinal plants combined with chemometric analysis to identify potential leads

Moyo,

Ofori,

Bodede

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

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Fermented lily bulbs by “Jiangshui” probiotics improves lung health in mice

Khan,

Wang,

et al. 2024

Food Chemistry

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Peroxiredoxin I and II as novel therapeutic molecular targets in cervical cancer treatment through regulation of endoplasmic reticulum stress induced by bleomycin

Sun,

Ma,

Guo

et al. 2024

Cell Death Discov.

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Cervical cancer, significantly affecting women worldwide, often involves treatment with bleomycin, an anticancer agent targeting breast, ovarian, and cervical cancers by generating reactive oxygen species (ROS) to induce cancer cell death. The Peroxiredoxin (PRDX) family, particularly PRDX1 and 2, plays a vital role in maintaining cellular balance by scavenging ROS, thus mitigating the damaging effects of bleomycin-induced mitochondrial and cellular oxidative stress. This process reduces endoplasmic reticulum (ER) stress and prevents cell apoptosis. However, reducing PRDX1 and 2 levels reverses their protective effect, increasing apoptosis. This research highlights the importance of PRDX1 and 2 in cervical cancer treatments with bleomycin, showing their potential to enhance treatment efficacy by managing ROS and ER stress and suggesting a therapeutic strategy for improving outcomes in cervical cancer treatment.

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Betulin and Crinum asiaticum L. bulbs extract attenuate pulmonary fibrosis by down regulating pro-fibrotic and pro-inflammatory cytokines in bleomycin-induced fibrosis mice model

Cited by 4 publications

References 82 publications

Investigation of the antimycobacterial activity of African medicinal plants combined with chemometric analysis to identify potential leads

Investigation of the antimycobacterial activity of African medicinal plants combined with chemometric analysis to identify potential leads

Fermented lily bulbs by “Jiangshui” probiotics improves lung health in mice

Peroxiredoxin I and II as novel therapeutic molecular targets in cervical cancer treatment through regulation of endoplasmic reticulum stress induced by bleomycin

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