Betulinic acid, isolated from the leaves of Syzygium cumini (L.) Skeels, ameliorates the proteinuria in experimental membranous nephropathy through regulating Nrf2/NF-κB pathways

Sutariya, Brijesh; Taneja, Neetika; Saraf, M. N.

doi:10.1016/j.cbi.2017.07.011

Cited by 40 publications

(24 citation statements)

References 46 publications

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“…The results of the present study also revealed a significant elevation in the levels of serum cholesterol and triglycerides in MGN rats when compared to controls. The results are in consonance with the earlier reports 35. Treatment with ILQ or TPCA-1 significantly improved the MGN induced hypercholesterolemia and hypertriglyceridemia in rats.…”

Section: Discussionsupporting

confidence: 92%

“…The increase might be due to the inflammatory effects observed in the study. Similar results were observed in rats induced with membranous nephropathy 35. On the other hand, treatment with ILQ or TPCA-1 significantly reduced the kidney weights and its somatic indices when compared to MGN rats.…”

Section: Discussionsupporting

confidence: 82%

“…Previously, it was reported that hyperlipidemia can aggravate the progression of kidney damage through oxidative stress 38. The increased ROS generation plays a major role in MGN pathogenesis 35. In the current study, a significant increase in MDA and NO levels associated with a significant decrease in SOD, CAT, GPx and GSH activity was observed in the MGN rats kidney compared to control rats.…”

Section: Discussionsupporting

confidence: 58%

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<p>Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties</p>

Liu¹,

Xu²,

Xu³

et al. 2019

DDDT

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BackgroundMembranous glomerulonephritis (MGN) is a nephrotic syndrome which shows the symptoms of heavy proteinuria and immune complex deposition in glomerular sub-epithelial space and finally leads to chronic kidney disease. Isoliquiritin (ILQ) is a flavonoid with a wide range of pharmacological properties, including antioxidant and anti-inflammatory activity. The present study was undertaken to investigate the possible mechanisms by which ILQ ameliorates cationic bovine serum albumin (C-BSA) induced MGN in rat model.MethodsThe MGN condition was confirmed by the 24 hr proteinuria and ILQ (10 mg/kg/bw/day) or TPCA-1 (10 mg/kg/bw/day; IKKβ inhibitor) was administered to successfully induce rats for 4 weeks.ResultsThe present study revealed that MGN rats treated with ILQ showed significantly ameliorated kidney dysfunction and histopathological changes in kidneys. ILQ treated MGN rats alleviated the oxidative stress and were presented with increased anti-oxidative status in kidneys. Furthermore, ILQ treatment to MGN rats showed anti-oxidative effects through the prominent stimulation of Nrf2 signaling pathway and inhibition of Keap1, which consequently increases the Nrf2 nuclear translocation and thereby induces expression of NQO1 and HO-1. In addition, ILQ-treated MGN rats demonstrated anti-inflammatory effects by inhibiting NF-κB signaling pathway through decreased mRNA and protein expressions of NF-κB p65, IKKβ, COX-2, iNOS, p38-MAPK, p-p38-MAPK, TNF-α, IL-1β, IL-8, ICAM-1, E-selectin and VCAM-1 and reduced the nuclear translocation of NF-κB p65.ConclusionThe protective effect of ILQ on MGN can be explained by its anti-oxidative and anti-inflammatory activities, which in turn due to the activation of Nrf2 and downregulation of NF-κB pathway.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 58%

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<p>Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties</p>

Liu¹,

Xu²,

Xu³

et al. 2019

DDDT

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show abstract

“…SOD activity and catalase (CAT) activity were determined using a commercially available colorimetric assay kit using a microplate reader (Synergy HTX Multi-Mode Microplate Reader, BioTek Instruments, United States). Lipid peroxidation was evaluated by measuring thiobarbituric acid reactive substances (TBARS) as described earlier[ 26 ].…”

Section: Methodsmentioning

confidence: 99%

Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus

Patel¹,

Joharapurkar²,

Kshirsagar³

et al. 2018

WJD

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AIMTo investigate the role of glucagon-like peptide-1 (GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity.METHODSChronic high-fat diet fed C57BL/6J mice, streptozotocin-treated high-fat diet fed C57BL/6J mice and diabetic C57BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocin-treated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist (Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist (Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment.RESULTSCoagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes (SREBP-1C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation (CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-α. Coagonist treatment reduced expression of inflammatory (TNF-α, MCP-1, and MMP-9) and pro-fibrotic (TGF-β, COL1A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSIONCoagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia.

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“…It is well know that NF-κB play an important regulator role in immune response ( Bhatt and Ghosh, 2014 ). Recent studies have shown that NF-κB also participates in the pathogenesis of MN ( Sutariya et al., 2017 ). Zhenwu Decoction can reduce the expression of pro-inflammatory factors by inhibiting the level of NF-κB and NLRP3,which will reduce cell apoptosis( Liu et al., 2019a ).…”

Section: Study On Mechanism Of Herb Medicine Treatment Of Imnmentioning

confidence: 99%

How Does Herbal Medicine Treat Idiopathic Membranous Nephropathy?

et al. 2020

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Idiopathic membranous nephropathy (IMN) has made increasing progress in mechanism and treatment research. Herbal medicine is gradually being accepted as an alternative therapy in treating IMN. However, the intervention mechanism of herbal medicine in the treatment of membranous nephropathy is still unclear. In this review, we summarize some achievements of herb medicine in treating IMN and discuss the research direction of herb in IMN. Finally, we propose the dilemma about the study on the treatment of IMN with herb medicine. We hope that this article can bring some thoughts for clinical and scientific researchers on the treatment of IMN with herb medicine.

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Betulinic acid, isolated from the leaves of Syzygium cumini (L.) Skeels, ameliorates the proteinuria in experimental membranous nephropathy through regulating Nrf2/NF-κB pathways

Cited by 40 publications

References 46 publications

<p>Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties</p>

<p>Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties</p>

Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus

How Does Herbal Medicine Treat Idiopathic Membranous Nephropathy?

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