Betulinic acid regulates tumor-associated macrophage M2 polarization and plays a role in inhibiting the liver cancer progression

Li, Guo; Pei, Hongyan; Yang, Yi; Kong, Yun

doi:10.1016/j.intimp.2023.110614

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…STAT3, a downstream target of IL-10 and IL-6, becomes activated and translocates to the nucleus, where it induces the expression of M2 genes ( Hakeem et al, 2023 ; Zhang et al, 2023 ). Other sources of cytokines like IL-4, IL-13, and transforming growth factor-β (TGF-β) further reinforce M2 polarization through the activation of STAT6 ( Guo et al, 2023 ). TGF-β regulates the expression of related genes by activating its downstream signaling molecules, Smad2 and Smad3.…”

Section: The Mechanism Of Macrophage Polarization In Alcohol-associat...mentioning

confidence: 99%

Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review

Sun,

Zhao,

Shi

et al. 2023

Front. Cell Dev. Biol.

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Alcohol-associated liver disease (ALD) is a condition that develops due to prolonged and excessive alcohol consumption. It encompasses various stages of liver damage, including fatty liver, alcoholic hepatitis, and cirrhosis. Immune cells, particularly macrophages, of various types play a significant role in the onset and progression of the disease. Macrophages observed in the liver exhibit diverse differentiation forms, and perform a range of functions. Beyond M1 and M2 macrophages, human macrophages can polarize into distinct phenotypes in response to various stimuli. Recent advancements have improved our understanding of macrophage diversity and their role in the progression of ALD. This mini-review provides a concise overview of the latest findings on the role and differentiation of macrophages in ALD. Additionally, it discusses potential therapeutic targets associated with macrophages and explores potential therapeutic strategies.

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Section: The Mechanism Of Macrophage Polarization In Alcohol-associat...mentioning

confidence: 99%

Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review

Sun,

Zhao,

Shi

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

Design, Synthesis, and Anticancer Activity Evaluation of Novel Betulin Derivatives

Bu,

Zhang,

Pan

et al. 2024

Russ J Gen Chem

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Betulinic acid regulates tumor-associated macrophage M2 polarization and plays a role in inhibiting the liver cancer progression

Cited by 2 publications

References 23 publications

Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review

Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review

Design, Synthesis, and Anticancer Activity Evaluation of Novel Betulin Derivatives

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