Bevacizumab Therapy for Tamoxifen-Induced Crystalline Retinopathy and Severe Cystoid Macular Edema

Rahimy, Ehsan; Sarraf, David

doi:10.1001/archophthalmol.2011.2741

Cited by 18 publications

(9 citation statements)

References 6 publications

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“…This approach has achieved no to questionable results in taxanes-related CME, 8 but had good results with tamoxifen-related CME. 9 We can hypothesize that PPS-induced CME is mediated, at least partly, by VEGF, a potent inducer of vascular permeability. We do not think that stopping PPS played a role in the rapid improvement of our patient's VA and OCT findings.…”

Section: Discussionmentioning

confidence: 99%

Pentosan Polysulfate Sodium-Induced Pigmentary Maculopathy With Nonleaking Cystoid Macular Edema Successfully Treated With Anti–vascular Endothelial Growth Factor Therapy

Larochellière

Bourgault

2022

RETINAL Cases &Amp; Brief Reports

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We report a case of pentosan polysulfate sodium-induced pigmentary maculopathy with nonleaking cystoid macular edema in both eyes. Our patient showed marked cystoid macular edema improvement and increased VA with treatment. The nonleaking characteristic of the cystoid macular edema associated with pentosan polysulfate sodium toxicity and its treatment with anti–vascular endothelial growth factor have never been described.

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Section: Discussionmentioning

confidence: 99%

Pentosan Polysulfate Sodium-Induced Pigmentary Maculopathy With Nonleaking Cystoid Macular Edema Successfully Treated With Anti–vascular Endothelial Growth Factor Therapy

Larochellière

Bourgault

2022

RETINAL Cases &Amp; Brief Reports

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“…Well documented tamoxifen induced toxicity includes keratopathy, cataract and optic neuritis but the most potentially devastating side effect is the development of crystalline retinopathy associated with cystoid macular edema (CME) [56–59]. The brilliant intraretinal crystals typically cluster within the perifoveal macular region with a characteristic annular distribution that may vary in density.…”

Section: Tamoxifenmentioning

confidence: 99%

“…However, vision decline is more commonly a consequence of CME, which can even occur in low cumulative doses [53, 54]. Crystals may improve or clear with discontinuation of systemic therapy and CME can resolve with anti-VEGF injections [56]. Crystalline toxicity is very rare with the more popularized safer dosages used for adjuvant breast cancer therapy.…”

Section: Tamoxifenmentioning

confidence: 99%

Wide field retinal imaging and the detection of drug associated retinal toxicity

Corradetti

Violanti

et al. 2019

Int J Retin Vitr

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BackgroundTo describe the peripheral retinal findings associated with systemic medication toxicity and to outline the importance of ultra-widefield imaging in the detection, analysis and monitoring of these abnormalities.Main textThis review highlights the retinal manifestations associated with the more common drug toxicities, with emphasis on the peripheral features and the indications for wide field imaging. The presenting findings, underlying pathophysiology, and retinal alterations in hydroxychloroquine, thioridazine, didanosine, tamoxifen, MEK-inhibitor, and immune checkpoint inhibitor associated drug toxicity will be described and the importance of wide field imaging in the evaluation of these abnormalities will be emphasized.ConclusionsWide field retinal imaging can improve the detection of peripheral retinal abnormalities associated with drug toxicity and may be an important tool in the diagnosis and management of these disorders.

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“…Besides, TAM is reported to uncouple electron transport chain and increases nitric oxide formation, lipid peroxidation, and releases cytochrome c from liver mitochondria (Mandlekar & Kong, 2001; Nazarewicz et al., 2007) further eliciting its toxicity. Several reports on the side effects of TAM in vivo include the formation of crystalline retinopathy and cataracts (Drenser et al., 2006; Rahimy & Sarraf, 2012), and steatohepatitis of the liver (Leal et al., 2018; Saphner et al., 2009). TAM also increases the number of the cystic follicle and decrease ovarian corpus luteal (Cho et al., 2003; Tsujioka et al., 2009) with implication for reproductive toxicities.…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic acid co‐administration abates tamoxifen‐mediated reproductive toxicities in male rats: An experimental approach

et al. 2021

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Reports over the years have demonstrated toxic side effect-including reproductive toxicity-of tamoxifen (TAM), a drug of choice in the management of primary breast cancer. Chlorogenic acid (CGA), a dietary polyphenol, reportedly elicits beneficial pharmacological effects. However, the impact of CGA on TAM-associated reproductive toxicity is absent in the literature. We, therefore, experimented on CGA's effect and TAM-mediated reproductive toxicity in rats. Cohorts of rats were treated with TAM (50 mg/kg) or co-treated with CGA (25 or 50 mg/kg) for 14 consecutive days. The result showed that treatment of CGA significantly increases testosterone, LH, and FSH levels compared to the TAM group. However, prolactin level was markedly decreased after pretreatment of CGA in TAM-treated rats. CGA abated TAM-induced decreases acid phosphatase, alkaline phosphatase, and antioxidant enzymes in the testis. CGA alleviated TAM-facilitated surges of reactive oxygen and nitrogen species, myeloperoxidase, nitric oxide, interleukin-1β, and tumor necrosis factor-alpha in rats epididymis and testes. Additionally, CGA increased anti-inflammatory cytokine-interleukin-10-, suppressed caspase-3 activity, and reduced pathological lesions in the examined organs of rats co-treated with CGA and TAM. CGA phytoprotective effect improved reproductive function occasioned by TAM-mediated toxicities in rats, by abating oxido-inflammatory damages and downregulating apoptotic responses. Practical applications CGA protects against the damaging oxido-inflammatory responses incumbent on TAM metabolism. As an antioxidant abundant in plant-derived foods, CGA reportedly protects against inflammatory damage, hypertension, and neurodegenerative diseases. We present evidence that CGA ameliorates TAM-induced reproductive dysfunction by suppressing oxidative and inflammation stress downregulate apoptosis and improve reproductive function biomarker in rats.

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Bevacizumab Therapy for Tamoxifen-Induced Crystalline Retinopathy and Severe Cystoid Macular Edema

Cited by 18 publications

References 6 publications

Pentosan Polysulfate Sodium-Induced Pigmentary Maculopathy With Nonleaking Cystoid Macular Edema Successfully Treated With Anti–vascular Endothelial Growth Factor Therapy

Pentosan Polysulfate Sodium-Induced Pigmentary Maculopathy With Nonleaking Cystoid Macular Edema Successfully Treated With Anti–vascular Endothelial Growth Factor Therapy

Wide field retinal imaging and the detection of drug associated retinal toxicity

Chlorogenic acid co‐administration abates tamoxifen‐mediated reproductive toxicities in male rats: An experimental approach

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