Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers

Ni, Jiaojiao; Huang, Yihui; Li, Chaoqun; Yin, Qian; Ying, Jieer

doi:10.1016/j.omto.2023.100750

Cited by 4 publications

(1 citation statement)

References 121 publications

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“…Targeting ENO2 or its associated metabolic pathways has been explored as a potential therapeutic strategy in some cancers, though clinical applications are still under investigation [23]. In our study, high expression of ENO2 in COAD tumors may sensitize the cancer cells to certain therapeutic agents, such as chemotherapies (e.g., Vinblastine, Cisplatin, Fludarabine) and targeted therapies (e.g., Dasatinib, Le unomide, Entospletinib, AZD8186, AMG-319).…”

Section: Discussionmentioning

confidence: 77%

ENO2 in Progression and Treatment of Colon Adenocarcinoma Based on Non-Apoptotic Cell Death

Tang,

Wang,

Tang

2024

Preprint

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Colon adenocarcinoma (COAD) is one of the most common types of cancer. The interconnection between non-apoptotic cell death and COAD has not been adequately addressed. In our study, an integrative computational analysis was performed to explore non-apoptotic cell death-related biomarkers in COAD. ENO2 was determined as a potent biomarker for prognosis, drug response, immunity, and immunotherapy prediction. We used EdU and RT-qPCR assays to test our hypothesis and investigate how the ENO2 gene may influence or regulate cancer-related processes. ENO2 was expected to be a potential target in COAD.

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Section: Discussionmentioning

confidence: 77%

ENO2 in Progression and Treatment of Colon Adenocarcinoma Based on Non-Apoptotic Cell Death

Tang,

Wang,

Tang

2024

Preprint

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HOXC6‐mediated transcriptional activation of ENO2 promotes oral squamous cell carcinoma progression through the Warburg effect

Feng,

Fang

2024

J Biochem & Molecular Tox

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Oral squamous cell carcinoma (OSCC) requires an in‐depth exploration of its molecular mechanisms. The Warburg effect, along with the oncogenes enolase 2 (ENO2) and homeobox C6 (HOXC6), plays a central role in cancer. However, the specific interaction between ENO2 and HOXC6 in driving the Warburg effect and OSCC progression remains poorly understood. Through differential gene expression analysis in head and neck squamous cell carcinomas using Gene Expression Profiling Interactive Analysis, we identified upregulated ENO2 in OSCC. Silencing ENO2 in OSCC cells revealed its involvement in migration, invasion, and aerobic glycolysis of OSCC cells. Further exploration of ENO2's regulatory network identified HOXC6 as a potential transcriptional regulator. Subsequently, HOXC6 was silenced in OSCC cells, and expressions of ENO2 were assessed to validate its relationship with ENO2. Chromatin Immunoprecipitation and luciferase assays were utilized to investigate the direct transcriptional activation of ENO2 by HOXC6. A rescue assay co‐overexpressing ENO2 and silencing HOXC6 in OSCC cells affirmed HOXC6's role in ENO2‐associated glycolysis. High ENO2 expression in OSCC was validated through quantitative real‐time polymerase chain reaction, Western blot, and immunohistochemistry analyses, which correlated with poor patient survival. Functional assays demonstrated that ENO2 silencing inhibited glycolysis and attenuated the aggressiveness of OSCC cells. In vivo studies confirmed the oncogenic role of ENO2 in OSCC growth. Notably, HOXC6 exhibited a positive correlation with ENO2 expression in clinical samples. Mechanistically, HOXC6 was identified as a direct transcriptional activator of ENO2, orchestrating the Warburg effect in OSCC cells. This study reveals the intricate link between HOXC6‐mediated ENO2 transcriptional activation and the Warburg effect in OSCC, offering a potential therapeutic target for treating OSCC patients.

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ENO2 in progression and treatment of colon adenocarcinoma: integrative bioinformatics analysis on non-apoptotic cell death

Tang,

Wang,

Tang

2024

Discov Onc

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Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers

Cited by 4 publications

References 121 publications

ENO2 in Progression and Treatment of Colon Adenocarcinoma Based on Non-Apoptotic Cell Death

ENO2 in Progression and Treatment of Colon Adenocarcinoma Based on Non-Apoptotic Cell Death

HOXC6‐mediated transcriptional activation of ENO2 promotes oral squamous cell carcinoma progression through the Warburg effect

ENO2 in progression and treatment of colon adenocarcinoma: integrative bioinformatics analysis on non-apoptotic cell death

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