Beyond eosinophilia: inflammatory patterns in patients with asthma

Bedolla-Barajas, Martín; Morales-Romero, Jaime; Hernández-Colín, Dante Daniel; Larenas‐Linnemann, Désirée; Mariscal-Castro, Juan; Flores-Razo, Miriam Montzerrat; Bedolla-Pulido, Angie

doi:10.1080/02770903.2020.1852413

Cited by 12 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Basophilia was observed in 4.1% of asthmatic patients. This finding was lower than a similar study done in Mexico (37.7%) [ 57 ]. The possible reason for the discrepancy might be due to the difference in the reference range used (≥ 110 cells/μl versus > 200 cells/μl) and the sample size used.…”

Section: Discussioncontrasting

confidence: 81%

“…This finding is in line with the study conducted in the USA (18.5%) [ 53 ], the UK (16%) [ 54 ], and a cross-sectional survey of the US general population (18%) [ 55 ]. But the finding was lower than a pilot study conducted in the US (40%) [ 27 ], Japan (34%) [ 56 ], Canada (41%) [ 28 ], Brazil (40%) [ 29 ], Mexico (37.7%) [ 57 ], and the UK (43%) [ 58 ]. The possible explanation for the difference might be due to variation in study participants, socio-demographic characteristics, and sample size.…”

Section: Discussionmentioning

confidence: 82%

See 1 more Smart Citation

Selected hematological abnormalities and their associated factors among asthmatic patients in Northwest Ethiopia: a cross-sectional study

et al. 2022

View full text Add to dashboard Cite

Background Asthma is a chronic inflammatory disease that affects the lungs. Variation in whole blood cell lines is caused by the progression and severity of asthma. Common hematological abnormalities encountered during asthma include eosinophilia, neutrophilia, leukocytosis, and increased erythrocyte sedimentation rate. The main aim of this study was to assess the selected hematological abnormalities and their associated factors among asthmatic patients in Northwest Ethiopia from March to May 2021. Methodology A hospital-based cross-sectional study was conducted on a total of 320 asthmatic patients in Northwest Ethiopia. A simple random sampling technique was employed to select study participants. A pre-tested structured questionnaire and a checklist were used to collect data. Blood samples were collected from asthmatic patients for complete blood count and erythrocyte sedimentation rate determination. Hematological profiles were analyzed by Unicel DxH 800 (Beckman Coulter, Ireland). The erythrocyte sedimentation rate was determined by using the Westergren method. The data were entered into EpiData version 3.0.4 and analyzed with a statistical package for social science version 20 software. The bi-variable and multi-variable binary logistic regression models were used to assess the factors associated with hematological abnormalities. A p value of less than 0.05 in the multivariable logistic regression analysis was considered statistically significant. Results The overall prevalence of neutrophilia, eosinophilia, thrombocytopenia, leukocytosis, and basophilia was 35.3%, 20%, 11.9%, 10.3%, and 4.1%, respectively. Neutrophilia was associated with a lack of physical activity (AOR = 3.25; 95% CI 1.43–7.37) and a history of taking non-asthmatic drugs within the previous three months (AOR = 2.63; 95% CI 1.22–5.65). Being admitted to the emergency department (AOR = 0.27; 95% CI 0.11–5.67) was found to be associated with eosinophilia. In addition, being admitted to the emergency department (AOR = 5.44; 95%CI: 2.6–11.3) was associated with thrombocytopenia. Conclusion The current study demonstrated the predominant prevalence of neutrophilia, followed by eosinophilia, among asthma patients. Therefore, hematological abnormalities should be taken into account for proper monitoring and management of asthmatic patients.

show abstract

Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 82%

Selected hematological abnormalities and their associated factors among asthmatic patients in Northwest Ethiopia: a cross-sectional study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Different triggers of severe acute asthma can recruit neutrophils through IL-8 production by activated macrophages or epithelial cells, leading to diffuse bronchial inflammation. 23 Th1/Th2 and Treg/Th17 imbalances have been found in patients with asthma, so asthma may be closely associated with activated T cells in the lungs. 24 Here we showed that patients with asthma have higher NLR, NAR, and NBR levels than healthy controls, suggesting that neutrophils and activated T cells may play an important role in the pathogenesis of asthma.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil–lymphocyte ratios in blood to distinguish children with asthma exacerbation from healthy subjects

Pan

Ren

et al. 2023

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Objective Airway inflammation is a prominent feature of asthma and may play an important role in disease pathophysiology. Despite the increasing incidence of asthma worldwide, reliable diagnostic biomarkers are lacking and widely lead to asthma misdiagnosis. Neutrophil–lymphocyte ratio (NLR) is a biomarker of systemic inflammation, in addition to NLR–alanine aminotransferase ratio (NAR) and NLR–albumin ratio (NBR). The aim of this study was to evaluate associations of NLR, NAR, and NBR with diagnosis of childhood asthma to determine if they can aid clinical childhood asthma diagnosis. Methods This retrospective case-control study included 89 children with asthma and 53 healthy children from the Wuxi Children’s Hospital affiliated with Nanjing Medical University. We applied various statistical tests to the dataset: Mann–Whitney U test to compare characteristics of the case and control groups; chi-squared test to compare categorical variables; Kruskal–Wallis test to compare statistical differences of asthma indicators among groups; receiver operating characteristic (ROC) curves to assess the diagnostic value of indices; and Spearman correlation analysis to evaluate relationships between NLR and lactate dehydrogenase, albumin, aspartate transaminase, and alanine transaminase levels. Results Compared with controls, the asthma case group had significantly higher white blood cell ( p < 0.01), neutrophil, lactate dehydrogenase, C-reactive protein, and NLR levels ( p < 0.01) and significantly lower lymphocyte ( p = 0.001), platelet ( p = 0.039), and albumin levels ( p = 0.04). We determined optimal cutoff levels for several metrics: 1.723 for NLR, with sensitivity of 0.73 and specificity of 0.906; 0.135 for NAR, with sensitivity of 0.685 and specificity of 0.887; and 0.045 for NBR, with sensitivity of 0.674 and specificity of 0.906. The areas under the curve (AUCs) were 0.824 for NLR, 0.788 for NAR, 0.818 for NBR, and 0.83 for the combination of NLR + NAR + NBR. Conclusion The combination of NLR, NAR, and NBR biomarkers distinguished asthmatic ones suffering from exacerbation of the condition from healthy children. Thus, our results indicate NLR + NAR + NBR could be used as a clinical biomarker for asthma in children.

show abstract

“…This finding was consistent with the study conducted in the USA (18.5%) [35], the United Kingdom (16%) [36], Spain (20.7%) [37], and a cross-sectional survey of the United States general population (18%) [38]. However, the finding was lower than a study done in Japan (34%) [39], a pilot study in the USA (40%) [40], Canada (41%) [41], Brazil (40%) [42], Mexico (37.7%) [43], and the United Kingdom (43%) [44]. The possible reasons for the difference might be due to variation in study participants, socio-demographic characteristics, and sample size.…”

Section: Discussionmentioning

confidence: 83%

Peripheral blood eosinophilia in adult asthmatic patients and its association with the severity of asthma

et al. 2023

View full text Add to dashboard Cite

Background Asthma is a diverse disease with various etiologic bases. Severe asthma can be associated with increased mortality, hospitalization, and decreased quality of life for asthma patients. High blood eosinophil counts were associated with severe asthma, but recent studies have failed to confirm this as a marker of severe asthma among adult asthma patients. As a result, the purpose of this study was to determine the association between the severity of asthma and high blood eosinophil count. Methodology A simple random sampling technique was used to select 291 asthmatic patients for an institution-based cross-sectional study. Socio-demographic, behavioral, and clinical characteristics were collected by using a pre-tested structured questionnaire. Four milliliters of venous blood were collected from asthmatic patients for complete blood count and peripheral morphology assessment. The eosinophil count was analyzed by the Unicel DxH 800 (Beckman Coulter, Ireland) analyzer. A statistical package for social science version 20 (SPSS) software was used to analyze the data. The non-parametric (Mann-Whitney U) test was used to compare the eosinophil count with different background variables. A binary logistic regression analysis was used to assess the factors associated with eosinophilia. A p-value less than 0.05 in multivariable logistic regression analysis was considered statistically significant. Result In this study, the overall magnitude of eosinophilia was 19.6% (95% CI = 14.8–24.1). Being admitted to the emergency department (AOR = 0.25; 95% CI: 0.09–0.69, p = 0.007) and being female (AOR = 0.49; 95% CI: 0.26–0.9, p = 0.025) were shown to have a statistically significant association with eosinophilia. Moreover, the absolute eosinophil count was significantly higher among asthmatic patients infected with intestinal parasitic infection (p < 0.045). Conclusion Being female and admission to the emergency department were negatively associated with eosinophilia. Lack of eosinophilia can be related to the low-T2 asthma phenotype. The absolute eosinophil counts were higher among intestinal parasite-infected patients. Therefore, different biomarkers will be considered for the proper diagnosis and management of adult asthma patients.

show abstract

Beyond eosinophilia: inflammatory patterns in patients with asthma

Cited by 12 publications

References 20 publications

Selected hematological abnormalities and their associated factors among asthmatic patients in Northwest Ethiopia: a cross-sectional study

Selected hematological abnormalities and their associated factors among asthmatic patients in Northwest Ethiopia: a cross-sectional study

Neutrophil–lymphocyte ratios in blood to distinguish children with asthma exacerbation from healthy subjects

Peripheral blood eosinophilia in adult asthmatic patients and its association with the severity of asthma

Contact Info

Product

Resources

About