Beyond lowering circulating LDL: Apheresis-induced changes of systemic oxidative stress markers by four different techniques

Kopprasch, Steffi; Graessler, Juergen; Bornstein, Stefan R.; Schwarz, Peter E. H.; Tselmin, Sergey; Frind, Antje; Poberschin, Ines; Julius, Ulrich

doi:10.1016/s1567-5688(09)71807-0

Cited by 21 publications

(16 citation statements)

References 20 publications

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“…These studies were mostly conducted over a short period of time [1,2]; investigations of long-term effects of apheresis treatment on oxidative balance are rare [3]. In the present study, we examined the long-term effects of two lipoprotein apheresis techniques e (1) plasma lipidfiltration (LF, Diamed, Cologne, Germany, Octo Nova) and (2) whole blood dextran sulfate adsorption (DSA, Liposorber Ò D, Kaneka Corporation, Osaka, Japan) on circulating oxidative stress markers for up to two years.…”

Section: Introductionmentioning

confidence: 99%

Long-term therapeutic efficacy of lipoprotein apheresis on circulating oxidative stress parameters – A comparison of two different apheresis techniques

Kopprasch

Bornstein

Bergmann

et al. 2015

Atherosclerosis Supplements

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Section: Introductionmentioning

confidence: 99%

Long-term therapeutic efficacy of lipoprotein apheresis on circulating oxidative stress parameters – A comparison of two different apheresis techniques

Kopprasch

Bornstein

Bergmann

et al. 2015

Atherosclerosis Supplements

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“…Proteomic studies have provided evidence that beyond the clearance of lipoproteins, LDL apheresis columns bind a variety of proteins, such as factors of the coagulation and complement cascades as well as adhesive proteins. 24 DALI has been shown to reduce systemic markers of oxidative stress, 25 and clinical data suggest that LDL apheresis induces profound changes in plasma cytokines, promoting an anti-inflammatory and anti-atherogenic cytokine profile by direct adsorption of cytokines or by indirect effects on cytokine expression. 8,26 We evaluated the release of TNF-a, IL-6, IL-8, and IL-10 after incubation of whole blood with DALI and ReliSorb and observed elevated IL-8 levels for both adsorbents as compared with the control, while all other cytokines remained below the detection limit.…”

Section: Discussionmentioning

confidence: 99%

Release and cellular origin of extracellular vesicles during circulation of whole blood over adsorbent polymers for lipid apheresis

Weiss

Eichhorn

Spittler

et al. 2015

J. Biomed. Mater. Res.

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Whole blood lipid apheresis is clinically applied in patients with familial hypercholesterolemia to reduce low density lipoprotein and other apolipoprotein B 100 containing lipoproteins. Here, the hemocompatibility of two polyacrylate-coated polyacrylamide-based polymers for lipid apheresis by evaluating the adhesion of blood cells to the adsorbent polymers, their respective activation, as well as the release of microvesicles during circulation of whole blood over the polymers was studied. Characterization of the adsorbents by scanning electron microscopy, atomic force microscopy, and X-ray photoelectron spectroscopy revealed differences with respect to their surface morphology and their surface chemical composition. Despite these differences, equivalent amounts of leukocytes and platelets adhered to both polymers during circulation of whole blood over the adsorbent columns. The release of phosphatidylserine-exposing microvesicles, in contrast, increased significantly with increasing surface roughness and with the amount of polyacrylate groups at the adsorbent surface. The majority of microvesicles generated during blood-material contact were platelet-derived, and their release was associated with enhanced thrombin generation. Microvesicles were present in free and in cell-bound form, and 75% of all monocytes, but only 0.2% and 2.3% of red blood cells and platelets, respectively, were associated with microvesicles, pointing to a role of monocytes in the clearance of released microvesicles. Taken together, microvesicles are sensitive indicators for biomaterial-induced activation of blood cells in apheresis. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 636-646, 2017.

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“…This oxidative stress leads to cellular damage and so to haemolysis and platelet hyperactivation. Making a comparison between four different apheresis techniques (HELP, DALI, DFPP and IA), some authors observed interesting differences in biomarkers of systemic oxidative stress (Kopprasch et al , ). All apheresis procedures were equally effective in reducing LDLc, oxidised LDL and levels of anti‐oxLDL antibodies, but only the DALI, without separation of plasma, led to a reduction of leucocytes and to diminished phagocyte oxidant‐generating activity as measured by chemiluminescence (Napoli et al ; Napoli et al ).…”

Section: Systemic Oxidative Stress In Patients Undergoing Apheresismentioning

confidence: 99%

“…All apheresis procedures were equally effective in reducing LDLc, oxidised LDL and levels of anti‐oxLDL antibodies, but only the DALI, without separation of plasma, led to a reduction of leucocytes and to diminished phagocyte oxidant‐generating activity as measured by chemiluminescence (Napoli et al ; Napoli et al ). Moreover, DALI was the technique that was followed by a smaller reduction of blood total antioxidant capacity (Kopprasch et al , ). In a clinical trial involving uremic and dyslipidaemic patients, the effect of ascorbate supplementation on apheresis‐induced oxidative stress was evaluated by chemiluminescence‐emission spectrum and high‐performance liquid chromatography analysis.…”

Section: Systemic Oxidative Stress In Patients Undergoing Apheresismentioning

confidence: 99%

The use of therapeutic apheresis in cardiovascular disease

Pignalosa

Infante

Napoli

2014

Transfusion Medicine

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In the last few years, therapeutic apheresis (TA) has emerged as a valuable treatment option for certain life-threatening cardiovascular diseases (CVDs) and for all the cardiac dysfunctions caused by autoimmune or metabolic disorders. Besides the well-established indications for apheresis treatment, such as familial hypercholesterolaemia, hyperviscosity syndrome and thrombotic thrombocytopenic purpura (TTP), we discuss the novel approaches in the therapy of dilated cardiomyopathy, cardiac failure and some specific syndromes of severe dysfunction occurring after heart transplantation. The rationale for using apheresis in such patients is the contribution in immune modulation that this procedure can undoubtedly provide. The clinical course of TTP has dramatically changed, thanks to the introduction of therapeutic plasma exchange. Low-density lipoprotein apheresis has been extremely efficacious, safe and suitable for lowering cholesterol levels and can be used even for long-term treatment. In Waldenström macroglobulinaemia and other hyperviscosity syndromes, plasma exchange has demonstrated to be an efficient tool for reducing blood viscosity and the risk of a consequent cardiac dysfunction. However, TA may induce oxidative injury to erythrocytes, making these cells more prone to haemolysis and causing a significant reduction in their half-life. Ascorbate administration can be useful to lower the levels of hydrogen peroxide and proinflammatory mediators in patients undergoing apheresis. Further data are needed to support this benefit and to test other potential antioxidant therapies. Many of these therapeutic indications need further studies to be definitively approved, but preliminary data are encouraging.

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Beyond lowering circulating LDL: Apheresis-induced changes of systemic oxidative stress markers by four different techniques

Cited by 21 publications

References 20 publications

Long-term therapeutic efficacy of lipoprotein apheresis on circulating oxidative stress parameters – A comparison of two different apheresis techniques

Long-term therapeutic efficacy of lipoprotein apheresis on circulating oxidative stress parameters – A comparison of two different apheresis techniques

Release and cellular origin of extracellular vesicles during circulation of whole blood over adsorbent polymers for lipid apheresis

The use of therapeutic apheresis in cardiovascular disease

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