Beyond the smiley face: applications of structural DNA nanotechnology

Arora, Aakriti Alisha; Silva, Chamaree de

doi:10.1080/20022727.2018.1430976

Cited by 22 publications

(19 citation statements)

References 32 publications

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“…Third, deviations from equal monomer concentration reduce the effect, but with a notable exception if one species is rigid and the flexible species is in excess. We hope that the results and predictions presented here will stimulate exploration of magic-number effects in multivalent, multicomponent systems in both natural and synthetic contexts, such as lens crystallin proteins 33 or DNA origami 34 .…”

Section: Discussionmentioning

confidence: 83%

Rigidity enhances a magic-number effect in polymer phase separation

Weiner

et al. 2020

Nat Commun

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Cells possess non-membrane-bound bodies, many of which are now understood as phaseseparated condensates. One class of such condensates is composed of two polymer species, where each consists of repeated binding sites that interact in a one-to-one fashion with the binding sites of the other polymer. Biologically-motivated modeling revealed that phase separation is suppressed by a "magic-number effect" which occurs if the two polymers can form fully-bonded small oligomers by virtue of the number of binding sites in one polymer being an integer multiple of the number of binding sites of the other. Here we use latticemodel simulations and analytical calculations to show that this magic-number effect can be greatly enhanced if one of the polymer species has a rigid shape that allows for multiple distinct bonding conformations. Moreover, if one species is rigid, the effect is robust over a much greater range of relative concentrations of the two species.

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Section: Discussionmentioning

confidence: 83%

Rigidity enhances a magic-number effect in polymer phase separation

Weiner

et al. 2020

Nat Commun

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“…Such nanoparticles can be used to detect short oligonucleotides in a microbead-based assay [34] and can be applied in the biological field, nanoelectronics and nanophotonics [35]. Therefore, these designs provide comprehensive understanding of cellular interactions regarding tumor detection strategies [36,37].…”

Section: Synthesis Of Npsmentioning

confidence: 99%

Theranostic Nanoparticles and Their Spectrum in Cancer

Onaciu¹,

Jurj²,

Moldovan³

et al. 2020

Engineered Nanomaterials - Health and Safety

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Nanoparticles offer a lot of advantageous backgrounds for many applications due to their physical, chemical and biological properties. Their different composition (metals, lipids, polymers, peptides) and shapes (spheres, rods, pyramids, flowers and so on) are influenced by the synthesis methods and functionalization procedures. However, in the medical field, researchers focus on the biocompatibility and biodegradability of the nanoparticles in their attempts for a targeted therapy in which the nanocarriers need to bypass certain biological barriers. Moreover, the increased interest in molecular imaging has brought nanoparticles in the spotlight for their applications in two distinct directions: therapy and diagnosis. Furthermore, recent advances in nanoparticle designs have introduced novel nano-objects suitable as both detection and delivery systems at the same time, thus providing theranostic applications.

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“…DNA nanotechnology is a promising technique for various fields involving design, study, and application of synthetically created DNA nanostructures. The aim of DNA nanotechnology is to design synthetic DNA constructs for use in the organization molecules at a nanoscale, which exhibit structures and functions that are otherwise not contained in the natural DNA , . Various DNA structures have been in use as scaffolds for protein nanoarrays.…”

Section: Carrier Materialsmentioning

confidence: 99%

Immobilization of Lipases – A Review. Part II: Carrier Materials

Thangaraj

Solomon

2019

ChemBioEng Reviews

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Carriers used in the immobilization process play a major role in enhancing the properties of the biocatalyst. Polymers are used as organic carriers for enzyme immobilization to improve the thermal, chemical, and operational stability of the enzyme. A variety of carriers are used in the immobilization of enzymes, e.g., mica, silica, zeolites, hydrotalcites, activated carbon, gold and magnetic nanoparticles. Silica‐based carriers offer suitable matrices for enzyme immobilization to manufacture industrial products. Immobilization on nanoparticles has become attractive in biocatalytic applications due to the combination of physical, chemical, catalytic, electronic, and optical properties. Gold nanoparticles also have received attention in the preparation of biocatalysts due to the above‐mentioned reasons. Magnetic nanoparticles are used as a carrier since they can be isolated by an external magnetic field, which is of special interest in the synthesis of organic products such as biodiesel. Different carrier materials involved in the immobilization of enzymes are discussed in this paper.

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Beyond the smiley face: applications of structural DNA nanotechnology

Cited by 22 publications

References 32 publications

Rigidity enhances a magic-number effect in polymer phase separation

Rigidity enhances a magic-number effect in polymer phase separation

Theranostic Nanoparticles and Their Spectrum in Cancer

Immobilization of Lipases – A Review. Part II: Carrier Materials

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