ACM PATCH 2021, organized in conjunction with the 29th International Conference on User Modeling, Adaptation and Personalization, is the meeting point between researchers and practitioners of personalization in cultural heritage, aiming to enhance the user experience in digital and physical Cultural Heritage sites. The PATCH workshops started in 2007 and they are typically held in conjunction with UMAP, IUI and recently AVI Conference series. This paper summarizes the main ideas addressed in the articles accepted for presentation at PATCH 2021 and for publication in the workshop proceedings.